Protein Alignment Ythdf and Ythdf1

DIOPT Version :9

• Sequence 1: NP_001262943.1
• Gene: Ythdf / 42995
• FlyBaseID: FBgn0039261
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001019927.1
• Gene: Ythdf1 / 296467
• RGDID: 1308932
• Length: 559
• Species: Rattus norvegicus
• Alignment Length: 646
• Identity: 216/646 - (33%)
• Similarity: 284/646 - (43%)
• Gaps: 210/646 - (32%)

  Fly     2 SGVDQMKIPGNTAKSVEERNIPWSQQVDEASYE----NLSSPTHDEVSGNDNSMQFQYP-----P 57
            :.||..:..|...| |:..::.....|.:..:|    ..|:|::...|.:|..:...||     |
  Rat     4 TSVDPQRTKGQENK-VQNGSLHQKDAVHDNDFEPYLSGQSNPSNSYPSMSDPYLSSYYPPSIGFP 67

  Fly    58 FNFKENCNTPWNNMNK---------GRKANAN----HDSYRRHGHSIPNNTRRDEHQVNPWNSRK 109
            ::..|   .||:....         |:.:|.:    ||:.......:.||..:......|.|
  Rat    68 YSLSE---APWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQPGGLGNNIYQHRFNFFPEN--- 126

  Fly   110 PAAQSFRNENDQ----------------PS----TKLDNRT---SD--------EAQNQEVVA-- 141
            ||..::.....|                ||    |.:|.:|   ||        .:..|.:|.
  Rat   127 PAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGGTVVDGQTGFHSDTLNKAPGMNSLEQGMVGLK 191

  Fly   142 ------------------------------------APKKTTWASIASQPAKLTSRAASTTSNSK 170
                                                ..|.|:||:|||:|||...:..:
  Rat   192 IGDVTTSAVKTVGSVVNSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKT------ 250

  Fly   171 KKGP----GMPPPPMVPGKHNLDVNVWDLPNNKPPP-------VPSP---PSPIDLGYSDLSSDF 221
            |.||    .:||||:   |||:|:..||  |..|.|       .|||   |.|
  Rat   251 KSGPIVGGTLPPPPI---KHNMDIGTWD--NKGPAPKASAPQQTPSPQAAPQP------------ 298

  Fly   222 SISSNTAPPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVSPTGPVRRNLGPQQPVHHAAPR 286
               ...|.||..:...:                         |.|     :...||||:......
  Rat   299 ---QQVAQPLPVQPPPL-------------------------VQP-----QYQSPQQPLQPRWVA 330

  Fly   287 PATNAGPFGPPNARRHDGGPHPSRNSERSGNYSSFRGSEFESASKFEYRDENQSRPVEATSATEE 351
            |......||      ..||.:...||..|                        ::|..|.|
  Rat   331 PRNRNAAFG------QSGGANSDSNSVGS------------------------AQPTSAPS---- 361

  Fly   352 LPVDSQLVLDELKDKNNYNPKVLD--LKKAGSARFFVIKSYSEDDIHRSIKYEIWCSTDHGNKRL 414
              |:|..||::||..::||||..|  ||   |.|.|:|||||||||||||||.|||||:||||||
  Rat   362 --VESHPVLEKLKAAHSYNPKEFDWNLK---SGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRL 421

  Fly   415 DDAFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVWSQDKWRGKFKVKWIYVKDVP 479
            |.||:....: |.:.|.|||||||||||:|:|.:||||.:::.|||||||:|||.||||:|||||
  Rat   422 DGAFRSMSSK-GPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVKWIFVKDVP 485

  Fly   480 NGTLRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILHSYNHSTSIFDDFFHYEKKQEEE 540
            |..|||||||||:||.|||||||||||.:|..:||:|:.||.|:|||||||.||||:||||
  Rat   486 NNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEE 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_001262943.1	YTH	382..518	CDD:309322	96/135 (71%)
Ythdf1	NP_001019927.1	RPA_2b-aaRSs_OBF_like	<258..302	CDD:299125	18/63 (29%)
		YTH	390..523	CDD:282058	95/133 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345444
Domainoid	1	1.000	210	1.000	Domainoid score	I2721
eggNOG	1	0.900	-	-		E1_KOG1901
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2746
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000639
OrthoInspector	1	1.000	-	-		otm45474
orthoMCL	1	0.900	-	-		OOG6_102335
Panther	1	1.100	-	-	LDO	PTHR12357
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X383
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.790