Protein Alignment Ythdf and YTHDF3

DIOPT Version :9

• Sequence 1: NP_001262943.1
• Gene: Ythdf / 42995
• FlyBaseID: FBgn0039261
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_001264742.1
• Gene: YTHDF3 / 253943
• HGNCID: 26465
• Length: 588
• Species: Homo sapiens
• Alignment Length: 417
• Identity: 180/417 - (43%)
• Similarity: 233/417 - (55%)
• Gaps: 81/417 - (19%)

  Fly   141 AAPKKTTWASIASQPAKLTSRAASTTSNSKKKGPGMPPPPMVPGKHNLDVNVWDLPNNKPPPVPS 205
            ||||.|:||:||.:|||...: .....|....|..:||||:   |||:::..||   .|...|.:
Human   234 AAPKPTSWAAIARKPAKPQPK-LKPKGNVGIGGSAVPPPPI---KHNMNIGTWD---EKGSVVKA 291

  Fly   206 PPS-PIDLGYSDLSSDFSISSNTAPPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVSPTGP 269
            ||: |:                 .||            :..::.           .:..:.|...
Human   292 PPTQPV-----------------LPP------------QTIIQQ-----------PQPLIQPPPL 316

  Fly   270 VRRNLGPQQPVHHAAPRPATNAGPFGPPNARRHDGGPHPS---------RNSERSGNYSSFRGSE 325
            |:..|..|||   ..|:|....||  .|.|:.|...|...         ||.....|.::..||
Human   317 VQSQLPQQQP---QPPQPQQQQGP--QPQAQPHQVQPQQQQLQNRWVAPRNRGAGFNQNNGAGS- 375

  Fly   326 FESASKFEYRDENQSRPVEATSATEELPVDSQLVLDELKDKNNYNPKVLD--LKKAGSARFFVIK 388
                       ||....|...||:.. .|:...||::||..||||||..|  ||   :.|.|:||
Human   376 -----------ENFGLGVVPVSASPS-SVEVHPVLEKLKAINNYNPKDFDWNLK---NGRVFIIK 425

  Fly   389 SYSEDDIHRSIKYEIWCSTDHGNKRLDDAFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYN 453
            |||||||||||||.|||||:|||||||.|::..:.: |.:.|.|||||||||||:|:|.:.||||
Human   426 SYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGK-GPLYLLFSVNGSGHFCGVAEMKSVVDYN 489

  Fly   454 STSSVWSQDKWRGKFKVKWIYVKDVPNGTLRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILH 518
            :.:.|||||||:|||:||||:||||||..|||||||||:||.|||||||||||.:|..:||:|:.
Human   490 AYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIA 554

  Fly   519 SYNHSTSIFDDFFHYEKKQEEEVSSKR 545
            ::.|:|||||||.||||:||||.:.:|
Human   555 TFKHTTSIFDDFAHYEKRQEEEEAMRR 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_001262943.1	YTH	382..518	CDD:309322	95/135 (70%)
YTHDF3	NP_001264742.1	YTH	420..553	CDD:367840	94/133 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151912
Domainoid	1	1.000	207	1.000	Domainoid score	I2882
eggNOG	1	0.900	-	-		E1_KOG1901
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2829
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000639
OrthoInspector	1	1.000	-	-		otm41347
orthoMCL	1	0.900	-	-		OOG6_102335
Panther	1	1.100	-	-	O	PTHR12357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2345
SonicParanoid	1	1.000	-	-		X383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.820