Protein Alignment Ythdf and Ythdf3

DIOPT Version :9

• Sequence 1: NP_001262943.1
• Gene: Ythdf / 42995
• FlyBaseID: FBgn0039261
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: XP_006535505.1
• Gene: Ythdf3 / 229096
• MGIID: 1918850
• Length: 600
• Species: Mus musculus
• Alignment Length: 576
• Identity: 208/576 - (36%)
• Similarity: 278/576 - (48%)
• Gaps: 127/576 - (22%)

  Fly    24 WSQQVDE-----ASYENLSSPTH----DEVSGNDNSMQFQYPPFNFKENCN--------TPWNNM 71
            ||...|:     .:|..:|:..|    |.|.....::. ..|||..:...|        :.|...
Mouse    91 WSTAGDQPMPYLTTYGQMSNGEHHYIPDGVFSQPGALG-NTPPFLGQHGFNFFPGNADFSTWGTS 154

  Fly    72 NKGRKANANHDSYRRHGHSIPNNTRR--DEHQV---NPWNSRKPAAQSFRNENDQPSTKL----- 126
            ....::..|......:|:. |::..|  .:.|.   |...|:.|...|.  |......|:
Mouse   155 GSQGQSTQNSAYSSSYGYP-PSSLGRAITDGQAGFGNDTLSKVPGISSI--EQGMTGLKIGGDLT 216

  Fly   127 -------------DNRTSDEAQNQEVV--AAPKKTTWASIASQPAKLTSRAASTTSNSKKKGPGM 176
                         ...||....|...|  ||||.|:||:||.:|||...: .....|....|..:
Mouse   217 AAVTKTVGTALSSSGMTSIATNNVPPVSSAAPKPTSWAAIARKPAKPQPK-LKPKGNVGIGGSAV 280

  Fly   177 PPPPMVPGKHNLDVNVWDLPNNKPPPVPSPPS-PIDLGYSDLSSDFSISSNTAPPLGARAEKVHK 240
            ||||:   |||:::..||   .|...|.:||: |:                 .||
Mouse   281 PPPPI---KHNMNIGTWD---EKGSVVKAPPTQPV-----------------LPP---------- 312

  Fly   241 DTENFLKYEHKGLGNNNNFSRAKVSPTGPVRRNLGPQQPVHHAAPRPATNAGPFGPPNARRHD-G 304
              :..::.           .:..:.|...|:..|..|||   ..|:|....||  .|.|:.|. .
Mouse   313 --QTIIQQ-----------PQPLIQPPPLVQSQLPQQQP---QPPQPQQQQGP--QPQAQPHQVQ 359

  Fly   305 GPHPS--------RNSERSGNYSSFRGSEFESASKFEYRDENQSRPVEATSATEELPVDSQLVLD 361
            ...|.        ||.....|.::..||            ||....|...||:.. .|:...||:
Mouse   360 SQQPQLQNRWVAPRNRGTGFNQNNGTGS------------ENFGLGVVPVSASPS-SVEVHPVLE 411

  Fly   362 ELKDKNNYNPKVLD--LKKAGSARFFVIKSYSEDDIHRSIKYEIWCSTDHGNKRLDDAFKERHEE 424
            :||..||||||..|  ||   :.|.|:|||||||||||||||.|||||:|||||||.|::..:.:
Mouse   412 KLKAINNYNPKDFDWNLK---NGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRLDAAYRSLNGK 473

  Fly   425 GGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVWSQDKWRGKFKVKWIYVKDVPNGTLRHIRLE 489
             |.:.|.|||||||||||:|:|.:.||||:.:.|||||||:|||:||||:||||||..|||||||
Mouse   474 -GPLYLLFSVNGSGHFCGVAEMKSVVDYNAYAGVWSQDKWKGKFEVKWIFVKDVPNNQLRHIRLE 537

  Fly   490 NNENKSVTNSRDTQEVPNDKGIEVLQILHSYNHSTSIFDDFFHYEKKQEEEVSSKR 545
            ||:||.|||||||||||.:|..:||:|:.::.|:|||||||.||||:||||.:.:|
Mouse   538 NNDNKPVTNSRDTQEVPLEKAKQVLKIIATFKHTTSIFDDFAHYEKRQEEEEAMRR 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_001262943.1	YTH	382..518	CDD:309322	95/135 (70%)
Ythdf3	XP_006535505.1	YTH	432..565	CDD:367840	94/133 (71%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842041
Domainoid	1	1.000	210	1.000	Domainoid score	I2812
eggNOG	1	0.900	-	-		E1_KOG1901
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	288	1.000	Inparanoid score	I2803
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000639
OrthoInspector	1	1.000	-	-		otm43405
orthoMCL	1	0.900	-	-		OOG6_102335
Panther	1	1.100	-	-	O	PTHR12357
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2345
SonicParanoid	1	1.000	-	-		X383
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.780