Protein Alignment Ythdf and Ythdf1

DIOPT Version :10

• Sequence 1: NP_651322.1
• Gene: Ythdf / 42995
• FlyBaseID: FBgn0039261
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_776122.1
• Gene: Ythdf1 / 228994
• MGIID: 1917431
• Length: 559
• Species: Mus musculus
• Alignment Length: 646
• Identity: 217/646 - (33%)
• Similarity: 285/646 - (44%)
• Gaps: 210/646 - (32%)

  Fly     2 SGVDQMKIPGNTAKSVEERNIPWSQQVDEASYE----NLSSPTHDEVSGNDNSMQFQYP-----P 57
            :.||..:..|...| |:..::.....|.:..:|    ..|:|::...|.:|..:...||     |
Mouse     4 TSVDPQRTKGQDNK-VQNGSLHQKDAVHDNDFEPYLSGQSNPSNSYPSMSDPYLSSYYPPSIGFP 67

  Fly    58 FNFKENCNTPWNNMNK---------GRKANAN----HDSYRRHGHSIPNNTRRDEHQVNPWNSRK 109
            ::..|   .||:....         |:.:|.:    ||:.......:.||..:......|.|
Mouse    68 YSLSE---APWSTAGDPPIPYLTTYGQLSNGDHHFMHDAVFGQPGGLGNNIYQHRFNFFPEN--- 126

  Fly   110 PAAQSFRNENDQ----------------PS----TKLDNRT---SD--------EAQNQEVVA-- 141
            ||..::.....|                ||    |.:|.:|   ||        .:..|.:|.
Mouse   127 PAFSAWGTSGSQGQQTQSSAYGSSYTYPPSSLGGTVVDGQTGFHSDSLNKAPGMNSLEQGMVGLK 191

  Fly   142 ------------------------------------APKKTTWASIASQPAKLTSRAASTTSNSK 170
                                                ..|.|:||:|||:|||...:..:
Mouse   192 IGDVTTSAVKTVGSVVNSVALTGVLSGNGGTNVNMPVSKPTSWAAIASKPAKPQPKMKT------ 250

  Fly   171 KKGP----GMPPPPMVPGKHNLDVNVWDLPNNKPPP-------VPSP---PSPIDLGYSDLSSDF 221
            |.||    .:||||:   |||:|:..||  |..|.|       .|||   |.|
Mouse   251 KSGPIVGGALPPPPI---KHNMDIGTWD--NKGPAPKASAPQQTPSPQAAPQP------------ 298

  Fly   222 SISSNTAPPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVSPTGPVRRNLGPQQPVHHAAPR 286
               ...|.||..:...:                         |.|     :...||||:......
Mouse   299 ---QQVAQPLPVQPPPL-------------------------VQP-----QYQSPQQPLQPRWVA 330

  Fly   287 PATNAGPFGPPNARRHDGGPHPSRNSERSGNYSSFRGSEFESASKFEYRDENQSRPVEATSATEE 351
            |......||      ..||.:...||  .||                      ::|..|.|
Mouse   331 PRNRNAAFG------QSGGANSDSNS--VGN----------------------AQPTSAPS---- 361

  Fly   352 LPVDSQLVLDELKDKNNYNPKVLD--LKKAGSARFFVIKSYSEDDIHRSIKYEIWCSTDHGNKRL 414
              |:|..||::||..::||||..|  ||   |.|.|:|||||||||||||||.|||||:||||||
Mouse   362 --VESHPVLEKLKAAHSYNPKEFDWNLK---SGRVFIIKSYSEDDIHRSIKYSIWCSTEHGNKRL 421

  Fly   415 DDAFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYNSTSSVWSQDKWRGKFKVKWIYVKDVP 479
            |.||:....: |.:.|.|||||||||||:|:|.:||||.:::.|||||||:|||.||||:|||||
Mouse   422 DGAFRSMSSK-GPVYLLFSVNGSGHFCGVAEMKSPVDYGTSAGVWSQDKWKGKFDVKWIFVKDVP 485

  Fly   480 NGTLRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILHSYNHSTSIFDDFFHYEKKQEEE 540
            |..|||||||||:||.|||||||||||.:|..:||:|:.||.|:|||||||.||||:||||
Mouse   486 NNQLRHIRLENNDNKPVTNSRDTQEVPLEKAKQVLKIIASYKHTTSIFDDFSHYEKRQEEE 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_651322.1	YTH	382..518	CDD:461195	96/135 (71%)
Ythdf1	NP_776122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		9/45 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	239..365		47/217 (22%)
		Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.	<258..302	CDD:471953	18/63 (29%)
		YTH	390..523	CDD:461195	95/133 (71%)