Protein Alignment Ythdf and Ythdf2

DIOPT Version :10

• Sequence 1: NP_651322.1
• Gene: Ythdf / 42995
• FlyBaseID: FBgn0039261
• Length: 700
• Species: Drosophila melanogaster
• Sequence 2: NP_663368.3
• Gene: Ythdf2 / 213541
• MGIID: 2444233
• Length: 579
• Species: Mus musculus
• Alignment Length: 417
• Identity: 179/417 - (42%)
• Similarity: 233/417 - (55%)
• Gaps: 86/417 - (20%)

  Fly   140 VAAPKKTTWASIASQPAKLTSRAASTTSNSKKKGPGMPPPPMVPGKHNLDVNVWDLPNNKPPPVP 204
            :|.||..:||.|||:|||...:..:....:   |..:||||:   |||:|:..||   ||.|...
Mouse   231 IAPPKPASWADIASKPAKQQPKLKTKNGIA---GSSLPPPPI---KHNMDIGTWD---NKGPVAK 286

  Fly   205 SPPSPI--DLGYSDLSSDFSI--SSNTAPPLGARAEKVHKDTENFLKYEHKGLGNNNNFSRAKVS 265
            :|...:  ::|.....|...:  .:|.:||: |:| .|.:.|:                   .:.
Mouse   287 APSQALVQNIGQPTQGSPQPVGQQANNSPPV-AQA-SVGQQTQ-------------------PLP 330

  Fly   266 PTGPVRRNLGPQ----QPVHHAAPRPATNAGP-FGPPNARRHDGGPHPSRNSERSGNYSSFRGSE 325
            |..|....|..|    ||....|||   |.|. ||      |:|.........::|:.|:
Mouse   331 PPPPQPAQLSVQQQAAQPTRWVAPR---NRGSGFG------HNGVDGNGVGQSQAGSGST----- 381

  Fly   326 FESASKFEYRDENQSRPVEATSATEELPVDSQLVLDELKDKNNYNPKVLD--LKKAGSARFFVIK 388
                                       |.:...||::|:..||||||..|  ||   ..|.|:||
Mouse   382 ---------------------------PSEPHPVLEKLRSINNYNPKDFDWNLK---HGRVFIIK 416

  Fly   389 SYSEDDIHRSIKYEIWCSTDHGNKRLDDAFKERHEEGGNIMLFFSVNGSGHFCGMAQMMTPVDYN 453
            |||||||||||||.|||||:|||||||.|::..:.: |.:.|.|||||||||||:|:|.:.||||
Mouse   417 SYSEDDIHRSIKYNIWCSTEHGNKRLDAAYRSMNGK-GPVYLLFSVNGSGHFCGVAEMKSAVDYN 480

  Fly   454 STSSVWSQDKWRGKFKVKWIYVKDVPNGTLRHIRLENNENKSVTNSRDTQEVPNDKGIEVLQILH 518
            :.:.|||||||:|:|.|:||:||||||..||||||||||||.|||||||||||.:|..:||:|:.
Mouse   481 TCAGVWSQDKWKGRFDVRWIFVKDVPNSQLRHIRLENNENKPVTNSRDTQEVPLEKAKQVLKIIA 545

  Fly   519 SYNHSTSIFDDFFHYEKKQEEEVSSKR 545
            ||.|:|||||||.||||:||||.|.|:
Mouse   546 SYKHTTSIFDDFSHYEKRQEEEESVKK 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ythdf	NP_651322.1	YTH	382..518	CDD:461195	94/135 (70%)
Ythdf2	NP_663368.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45
		Localization to mRNA processing bodies (P-bodies). /evidence=ECO:0000250|UniProtKB:Q9Y5A9	2..384		53/223 (24%)
		PHA03247	<200..359	CDD:223021	45/160 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	247..387		44/210 (21%)
		Interaction with m6A-containing mRNAs. /evidence=ECO:0000250|UniProtKB:Q9Y5A9	385..579		126/192 (66%)
		YTH	411..544	CDD:461195	93/133 (70%)