DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smg6 and SWT1

DIOPT Version :9

Sequence 1:	NP_651321.1	Gene:	Smg6 / 42994	FlyBaseID:	FBgn0039260	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_014809.3	Gene:	SWT1 / 854337	SGDID:	S000005692	Length:	458	Species:	Saccharomyces cerevisiae

Alignment Length:	363	Identity:	81/363 - (22%)
Similarity:	137/363 - (37%)	Gaps:	97/363 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 LLDEDVAL-RGFTPLGRETLSMDYLKRGSERLQFFERVRRIGQFQEYYVQHQEALQQPLESSFTV 685
            :.||..|. :|...:..||.:.....:.||.::....:|..|   :|.||..:.:     .:.|.
Yeast     1 MTDEKRAFPKGNNHIRSETFNGSVSHKISESIKDIASLRPHG---KYTVQDIDNI-----IASTS 57

  Fly   686 EHLNAAM---KNALENYDAES----CGLAANVSKIQCKAVEELLCRSTDSDV---SELCKLKKEL 740
            .|.|...   .|...|:|.|.    |.|                  :.:|||   ||....::|:
Yeast    58 SHENRGQSGDSNGCINHDEEGDIPMCDL------------------NDESDVEMISEYLSSQREM 104

  Fly   741 EAKARVKQICTSKLEDILKFVDTKIYIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRY--TLIIP 803
            ||::....:  .|:.|.|..::..   .::..::: |||..|..|...|||.:....|  .:|:|
Yeast   105 EAQSVANYM--PKINDDLPLLNPP---TLKTAFVV-DTNFIISHLNTLEKLRSLSSTYHHLIIVP 163

  Fly   804 LTVVKELDGLSKGVKLDSYRSSKQTQRIHHFDEVSSRAKKSLEFIKSAKGN---------VKCAT 859
            .||::|||||.|..  |..|.:..|....|...:.:.|:...::|.....|         :|.:.
Yeast   164 TTVIQELDGLKKSP--DIARDNDDTTNQEHDRTIGTLARWGNDWIYKNLANLDSGLIGQKLKQSL 226

  Fly   860 TKGSFVNASVFALVEEEYLSNDDKILATAMAVSKTAKTEQCTDGKCFIQTELVLITTDRNLRVKA 924
            ..||.               .||.||...:...:..        .||:    :|::.|:||..||
Yeast   227 NPGSL---------------KDDSILDCCLYFKEIL--------NCFV----ILLSNDKNLCTKA 264

  Fly   925 LSRN--------------LAVSALDEFLQWAKDCREST 948
            |:.:              :|:.|.:|......:.|:||
Yeast   265 LTEDILTVSFRKNMDAKIIAMRAYEENQLRFANLRDST 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	190..298	CDD:287360
		EST1_DNA_bind	310..638	CDD:287359	4/16 (25%)
		P-loop_NTPase	<616..>769	CDD:304359	33/157 (21%)
		PIN_Smg6	767..941	CDD:189055	45/198 (23%)
SWT1	NP_014809.3	PIN_Swt1-like	133..280	CDD:350294	42/176 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1427
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030