DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg6 and EBS1

DIOPT Version :9

Sequence 1:	NP_651321.1	Gene:	Smg6 / 42994	FlyBaseID:	FBgn0039260	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_010492.3	Gene:	EBS1 / 851787	SGDID:	S000002614	Length:	884	Species:	Saccharomyces cerevisiae

Alignment Length:	699	Identity:	122/699 - (17%)
Similarity:	241/699 - (34%)	Gaps:	211/699 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LPHAKN-IVHLYDQLMVLNQ--RNLILINWKNF-CYIHDQLQDAFKQLLLEQLKFVC--EHKVDV 222
            ||.|.| |....:.::..||  ::..|:|  .| .::|.:|..|    :|..::..|  ....|:
Yeast    11 LPTAFNGIKSQLNSILKSNQLFQDYALLN--GFLAFVHSKLNAA----ILTSIESQCGKSFAADL 69

  Fly   223 -------------FFWKLLFYNV-------RNYL------KRQQTD-----QAHTHTLLLIEQAI 256
                         |.|:.:.|.:       |||:      |:|||.     :.::..|...:...
Yeast    70 DSFDQSSISSILDFSWESVHYPIFKWFQMWRNYILFEKENKKQQTKFIDFRKMNSKMLKFFKTVQ 134

  Fly   257 KFY----RMLYDK-----LMAKCV-------------------------ASSRCDSALKVVAQRL 287
            .||    ..:|.|     |:.|.:                         :||.....:..:..|.
Yeast   135 NFYVNVINTVYKKYDISVLLPKRIIQDLKLSDIENTTNVGDILAVKTFNSSSPLAHLIPTLFHRC 199

  Fly   288 LICLGDLTRYRV------NHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVY 346
            |:.||...||:.      |....:::.::..:::.|..::|..|..::|...|.:.......||:
Yeast   200 LLFLGTAYRYKTLLEEISNKYSISNFKKSLDFFRLASLVLPSAGETYSQAGAIFLQTGNLGIAVF 264

  Fly   347 YYVRSLLTSN----SIQSAKESLLDLFDEIRRKYEETEMKQSPMHYAAGSKNQKSKQMRKEVWIY 407
            .:|:.::|..    ||::....::|....:.|....|.|..    |...||..::
Yeast   265 NFVKGMMTKMPSPVSIKNFGALMVDNKSSLNRSLHTTIMNT----YLQESKGPRT---------- 315

  Fly   408 PDGIRRLHRTDDKGNKAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTD-VDSLYP 471
                                             |.:|||.   ..:|.|.|.:::.|. .|...|
Yeast   316 ---------------------------------PAKEILE---FYFLGLFGSVWSPTSWRDDTKP 344

  Fly   472 LLRKLQIQIGVALRH-ENLLSRSKLLKIVALNLFVVEHNKPKTSRREMRYHSFNFANSFFGLMMK 535
                .|:..|:.||| ||.|..:...:.:         |..||.     :|:.......|.|::|
Yeast   345 ----NQLNNGIKLRHLENALYETMSARYL---------NNIKTI-----FHNLIITIGGFHLLLK 391

  Fly   536 KTNQLLAGFVEDSTNVQCLPEEDFATVNTYLQFVNVYVRWL--SISLDVW--EPVRSE---EHSF 593
            :.:.:.|..::|..:.:.          .||.|...|:..:  .|..:.|  .|..||   ....
Yeast   392 RRSDVSAKTLKDLRSNEL----------DYLNFAFKYIAHILNDIVKESWSENPEVSEILGMVRI 446

  Fly   594 IDCWAELTIL--------FEYIECL------MGKHK----------LEKNEILLDEDVALRGFTP 634
            |:||.:...:        .|::..|      :.|.|          :.|.....:||:.::|.:.
Yeast   447 INCWIKANPMVLQYSQSNLEFVNALAYLINDIVKKKPSPSFSITEHIPKRTYWFEEDLMVKGLSF 511

  Fly   635 LGRETLSMDYLKRGSERLQFFERVRRIGQFQEYYVQHQEALQQPLESSFTVEHLNAAMKNALENY 699
            :..:....|          .:|::..:....:..:.:.....:...||..:..|.|.:..:.:..
Yeast   512 VNFQLSDFD----------DYEKILEMDHSLDRLIGNPPLCDKLSASSEMLLRLQAVVNISSQLL 566

  Fly   700 DAESCGLAANVSKIQCKAVEELLCRSTDSDVSELCKLKKELEAKARVKQ 748
            ...:||:..:.:|.:....:::..:.|   |....|..|:...||::::
Yeast   567 QNNNCGVEWSDNKSRYIFNKKIGFKET---VKNSMKTSKQSNEKAKLQR 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	190..298	CDD:287360	31/175 (18%)
		EST1_DNA_bind	310..638	CDD:287359	65/364 (18%)
		P-loop_NTPase	<616..>769	CDD:304359	19/133 (14%)
		PIN_Smg6	767..941	CDD:189055
EBS1	NP_010492.3	EST1	80..214	CDD:402133	25/133 (19%)
EBS1	NP_010492.3	EST1_DNA_bind	228..516	CDD:402132	65/365 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15696
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000