Protein Alignment Smg6 and Smg5

DIOPT Version :10

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: XP_038959679.1
• Gene: Smg5 / 681012
• RGDID: 1584731
• Length: 1018
• Species: Rattus norvegicus
• Alignment Length: 1113
• Identity: 215/1113 - (19%)
• Similarity: 337/1113 - (30%)
• Gaps: 452/1113 - (40%)

  Fly   160 PLLGLPHAKNIVHLYDQLMVLNQRNLILINWKNFCYIHDQLQDAFKQ---LLLEQLKFVCE---- 217
            |||.|. ....||..|         |||.|...:       |:.||.   .|..:|:.:|.
  Rat    22 PLLTLA-VVEAVHRLD---------LILCNKTAY-------QEVFKPENVSLRNKLRELCVKLMF 69

  Fly   218 -HKVDV------FFWKLLFYNVRNYLKRQQTDQAHTHTLLLIEQA--------IKFYRML----- 262
             |.||.      ..|:.::|.|...:|   |::.|.|:...:|.|        |.||:.|
  Rat    70 LHPVDYGRKAEELLWRKVYYEVIQLIK---TNKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQ 131

  Fly   263 --YDKLMAKCV-----------------ASSRCDSALKVVAQRLLICLGDLTRYRVNHVKATD-Y 307
              |...:..|:                 ||.:.....::...|.|:.||||:||: |.:...| .
  Rat   132 SHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGDLSRYQ-NELAGVDTE 195

  Fly   308 MEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKESLLDLFDEI 372
            :.|.|:|.:|..:.|..|.|||||..::...:...:|:|.|:|.:.:..|.:.|..:|..|:|:.
  Rat   196 LLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYSVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKA 260

  Fly   373 RRKY--------------------------------------------EETEMKQS--------- 384
            .:.|                                            |.|.:.||
  Rat   261 AKMYHQLKKSETRKLSPSKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCL 325

  Fly   385 ---PMHYAAGSKNQKSKQMRKEVWIYPD------------GIRRLHRTDDKGNKA---------- 424
               |...:.|..|:..::........||            |:..|.|...|...|
  Rat   326 FYLPSSPSLGLTNEDEEECESGYAFLPDLLIFQMAIICLMGVHSLKRAGSKQYSAAIAFTLALFS 390

  Fly   425 ---------------KGNKATMA------------EVNRYEEMPPEEILPRIV-----------S 451
                           :|.....|            |....||..||.  |.:|           .
  Rat   391 HLINHVNIRLQAELEEGENPVSAFQSDGTDEPESKEALEKEEPEPEP--PTVVPQADEGRKSRKH 453

  Fly   452 LYLYLLGK--------------LYTGTDVDSLYPLL-----------RKLQIQIGVALRHE---- 487
            ..|..|.:              |..|.:.||.:...           :.|:.: |.|...|
  Rat   454 SRLSCLRRRRRHHPPKAGDDSDLSEGFESDSSHDSAQASDGSDSGSDKSLEGR-GTAFDAETDSE 517

  Fly   488 --NLLSRSKLLKI----------------------------------VALNLFVVEHNKPKTSRR 516
              :..|||.|..|                                  :|.||..:.....:|.|
  Rat   518 MNSQESRSDLEDIEDEEGTRSPAQEPPQTRSEVPDSLNGPLGPSEASIASNLQAMSTQMFQTKR- 581

  Fly   517 EMRYHSFNFANSFFGLMMKKTNQ---------LLAGFVE----------------DSTNVQCLPE 556
                 .|..|.:|..|:::.|.:         .:.|.:|                :|::..|..|
  Rat   582 -----CFRLAPTFSNLLLQPTAEPNSVASHRPCVNGDMEKPLEPASEDGSESEGSESSSRSCRNE 641

  Fly   557 EDF------ATVNTYLQFVNVYVRWLSISLDVWEPVRSEEHSFIDCWAELTILFEYIE------- 608
            ...      ......|..|.|::.||..:.|:.........|.   |..|::|...:.
  Rat   642 RSLQEKLQALMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSL---WNRLSVLLNLLPASGELQD 703

  Fly   609 -----CLMGKHKLEKNE-------ILLDEDVALRGFTPL-----------GRETLSMDYLKRGSE 650
                 |...:..||..|       :||.||:|||...||           .|..||.  |:....
  Rat   704 SGLALCSEVQGLLEGCELPDLPASLLLPEDMALRNLPPLRAAHRRFNFDADRPLLSA--LEESVV 766

  Fly   651 RL-------QFFERVR--------RIGQFQEYYVQHQEALQQPLESSFTVEHLNAAMKNALENYD 700
            |:       .|..|::        .:|.|.......||:|.|..::.|.:.. ..|.:|.|
  Rat   767 RICYIRSFGHFVARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAE-EEARRNRL---- 826

  Fly   701 AESCGLAANVSKIQCKAVEELLCRSTDSDVSELCKLKKELEAKARVKQICTSKLEDILKFVDTKI 765
                                         :.::.:|:.:||         .|:||..|:  ..|.
  Rat   827 -----------------------------MRDMAQLRLQLE---------VSQLEGSLQ--QPKA 851

  Fly   766 YIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRYTLIIPLTVVKELDGLSKGVKLDSYRSSKQTQR 830
            ...:.| ||:|||......|....:|:|. .|:.:|||.||:..||.|.|
  Rat   852 QSAMSP-YLIPDTQALCYHLPVIRQLATS-GRFIIIIPRTVIDGLDLLKK--------------- 899

  Fly   831 IHHFDEVSSRAKKSLEFIKS--AKGN--VKCATTKG-SFVNASVFALVEEEYLSNDD-------K 883
                  ....|:..:.::::  .|||  ::|....| ||         |...|...|       |
  Rat   900 ------EQPGARDGIRYLEAEFKKGNRYIRCQKEVGKSF---------ERHKLKRQDADAWTLYK 949

  Fly   884 ILATA--MAVSKTAKTEQCTDGKCFIQTELVLITTDRNL-RVKALSRNLAV-------------S 932
            ||.:.  :.:::.|..|.        .:.:|.|.|..:| ...|||..:..             :
  Rat   950 ILDSCRQLTLAQGAGEED--------PSGMVTIITGLHLDNPSALSGPMQAALQAAAHASVDVKN 1006

  Fly   933 ALDEFLQW 940
            .||.:.||
  Rat  1007 VLDFYRQW 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	219..298	CDD:463062	26/116 (22%)
		EST1_DNA_bind	310..639	CDD:431239	98/570 (17%)
		PIN_Smg6-like	767..941	CDD:350233	46/202 (23%)
Smg5	XP_038959679.1	EST1	78..189	CDD:463062	26/114 (23%)
		EST1_DNA_bind	198..>412	CDD:431239	36/213 (17%)
		EST1_DNA_bind	<653..746	CDD:431239	23/95 (24%)
		PIN_Smg5-like	857..1015	CDD:350232	46/198 (23%)