Protein Alignment Smg6 and smg7

DIOPT Version :10

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: XP_005171365.1
• Gene: smg7 / 565575
• ZFINID: ZDB-GENE-030131-9122
• Length: 1180
• Species: Danio rerio
• Alignment Length: 692
• Identity: 140/692 - (20%)
• Similarity: 232/692 - (33%)
• Gaps: 225/692 - (32%)

  Fly   200 LQDAFKQLLLEQLKFVCEHKVDVFFWKLLFYNVRNYLKRQQTDQAH-------THTLLLIEQAIK 257
            |||.::::|:..|::..:.||:...|...|.|....|:.|..::|:       .:..|.:|.|..
Zfish    35 LQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQSQAKNRANPNRSEVQANLSLFLEAASG 99

  Fly   258 FYRMLYDKLMA------KC-VASSRC-----------------DSALKVVAQRLLICLGDLTRYR 298
            ||..|..:|..      .| |.||:.                 .|:...:.|..|:.|||:.|||
Zfish   100 FYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQSSTSAIVKPQPSSCSYICQHCLVHLGDIARYR 164

  Fly   299 VNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSL-------LTSN 356
                  ....:|..||:.|.:|||.||.|:||||:::.........::||.||:       ..|.
Zfish   165 ------NQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAAST 223

  Fly   357 SIQSAKESLLDLFDEIRRKYEETEMKQSPMHYAAGSKNQKSKQMRKEVWIYPDGIRRLHRTDDKG 421
            ::|.|....|:..||::.|                             |...|
Zfish   224 NLQKALSKALESRDEVKTK-----------------------------WSVSD------------ 247

  Fly   422 NKAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTDVDSLYPLLRKLQIQIGVALRH 486
                                       .:..::...|.:|....:|.|..|..||:.|. ..|..
Zfish   248 ---------------------------FIKAFIKFHGHVYLCKSLDKLNTLREKLEEQF-QRLIL 284

  Fly   487 ENLLSRSKLLKIVALNLFVVEHNKPKTSRREMRYHSFN------------FANSFFGLM-----M 534
            :...|..:|:.|..:|||.:.|.:..::  |...||::            ...||.|:|     :
Zfish   285 QKAFSSQQLVHITVINLFELHHLRDLSN--EADEHSYSSDEQISWIQLLGLFMSFLGVMLSRALL 347

  Fly   535 KKTNQLLAGFVEDSTNVQC-LPEEDFATVNTYLQFVNVYVRWLSISLDVWEPVRSEEHSFIDCWA 598
            .|..:.:.|        :| ||.            :.|.:.||.:...|:.....::..:|..|
Zfish   348 NKNREEIMG--------ECPLPA------------IKVSLDWLRLRPTVFNESAMDKRQYIWPW- 391

  Fly   599 ELTILFEYIECLMGKHKLEKNE--ILLDEDVALRGFTPLGRETLSMDYLKR------GSERLQFF 655
                |...:.....|.:...|.  |.|.|:..|:||..|......:|:.|.      |.|.|...
Zfish   392 ----LVSILNSFQPKEEDVSNASVIPLPEEFELQGFLALRPALRMLDFSKGHQGIVIGKESLLIH 452

  Fly   656 ERVRRIGQFQEYYVQHQEAL---------------------------------------QQPLES 681
            .|.:|:....::...:|..|                                       |.|.||
Zfish   453 ARHQRLISLGKWVADNQPRLIQCRMSDGLVLFITDIPEIVVEEPQEKDTPVLQESSNGEQTPNES 517

  Fly   682 SFTVEHLNAAMKN---ALENYDAESCGLAANV-----SKIQCKAVEELLCRSTDSD--------- 729
            :..::.:.:|.||   .|:..:........|:     |:.|.:...:   |.|..|
Zfish   518 THGLKSVLSAGKNQNSGLDGSERPVVTFKENIKPREQSREQNRNQNQ---RDTGKDRAGFNKGNG 579

  Fly   730 VSELCKLKKELEAKARVKQICTSKLEDILKFVDTKIYIEVRP 771
            |....:.|||.:.|:.||:....|..|..|.|.|:..:...|
Zfish   580 VQGKNEQKKEGKRKSEVKKNSHDKTTDAGKQVKTQTELRKTP 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	219..298	CDD:463062	26/109 (24%)
		EST1_DNA_bind	310..639	CDD:431239	71/355 (20%)
		PIN_Smg6-like	767..941	CDD:350233	1/5 (20%)
smg7	XP_005171365.1	EST1	54..166	CDD:463062	28/117 (24%)
		TPR repeat	153..179	CDD:276809	11/31 (35%)
		EST1_DNA_bind	170..430	CDD:431239	71/355 (20%)
		TPR repeat	184..214	CDD:276809	11/29 (38%)