Protein Alignment Smg6 and smg5

DIOPT Version :9

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_001020094.1
• Gene: smg5 / 553261
• ZFINID: ZDB-GENE-050913-144
• Length: 1099
• Species: Danio rerio
• Alignment Length: 1181
• Identity: 203/1181 - (17%)
• Similarity: 361/1181 - (30%)
• Gaps: 500/1181 - (42%)

  Fly   165 PHAK--NIVHLYDQLMVLNQRNLILINWKNFCYIHDQLQDAFKQ---LLLEQLKFVCE-----HK 219
            |.||  :|..||..::....:..|:|:.|:      ..::.||.   .|..:|:.:|.     |.
Zfish    10 PEAKVLHIKRLYRAVVETVHKLDIIISGKS------SYREVFKPENISLRNKLRELCVKLMFLHP 68

  Fly   220 VDV------FFWKLLFYNVRNYLKRQQTDQAHTHTLLLIEQA--------IKFYRML-------Y 263
            ||.      ..|:.::|.|...:|   |::.|.|:...:|.|        :.|::.|       |
Zfish    69 VDYGRKAEELLWRKVYYEVIQVIK---TNKKHIHSRSALECAYRTHLIAGVGFFQHLLLYIQSHY 130

  Fly   264 DKLMAKCV-----------------ASSRCDSALKVVAQRLLICLGDLTRYRVNHVKATDYME-A 310
            ...:..|:                 |:|:.....::...|.|:.||||.||: |.:...:..: |
Zfish   131 QLELQDCIDWTHVTDPLIGRKKPVSATSKEMEWAQMACHRCLVYLGDLARYQ-NELAGVEAEQLA 194

  Fly   311 ARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKESLLDLFDEIRRK 375
            .|:|.:|..:.|..|.|||||..::.......:|.|||:|.:.:......|..:|..|||:..:.
Zfish   195 ERFYHQALSVAPHVGMPFNQLGTLAGSKFYNVEATYYYLRCIQSETPFDGAYGNLKRLFDKASKM 259

  Fly   376 YEET---EMKQ-SPMHYAAGSKNQKSKQMRKEV--WIYPDGI----RRLHRTD---------DKG 421
            |.:.   |||: ||       ..|:||.:::.:  ::|...:    ..|..|:         :..
Zfish   260 YHQVKKQEMKKLSP-------SRQRSKDIKRLLVSFMYLQSLLQPKNSLMETELTSLCQSVLEDF 317

  Fly   422 N--------KAKGNKATMAEVNRYEEMP---PEEILPRIVSLYLYLLGKLYTGT----------- 464
            |        .|.|:::...|...::.:.   |:.::.::|.:.|.::..|..|.
Zfish   318 NLVLFYLPLPAHGSQSASEEEEEHDSVGSVLPDSLIFKMVVICLMVVHSLKRGASKQYSASIAFT 382

  Fly   465 --------------------DVDSLYPLLR-------KLQIQIGVALRHENLL------------ 490
                                :.:|..|.||       ..:.....||..|..|
Zfish   383 LALFSHLVNHVNIRLQAELEEGESDVPALRTDNTDDADARDHSSAALSEERTLQNGSLEEDDDEE 447

  Fly   491 ----------------------------------------SRSKLLK------------------ 497
                                                    ||..:|:
Zfish   448 EEEKENGEDEPKGNGRTVATKKNQEKKRSAEEKQKQKRKFSRLSMLRRRRCAHKEDESDLSEGFE 512

  Fly   498 -----------------------IVALN----------------------------LFVV----- 506
                                   .|.:|                            .|.|
Zfish   513 SDEEEEEEEEGGGGGLVDGLGAPRVQMNSLGRDTRKGPLPEDGGWESGSEEDEGGTAFDVETDSD 577

  Fly   507 --------------------------EHNKPKTSRRE---------------------------- 517
                                      |:.:|:|||.|
Zfish   578 MNSQESRSDLEDMEDAENAPQQPQQEENEQPQTSREENATPPVTNGPSVSNDASISSNLQAMSSQ 642

  Fly   518 --MRYHSFNFANSFFGLMMK------------------------KTNQLLAGFVEDSTNVQCLPE 556
              .....|..|.:|..::::                        :|.:..:..:.:.||.:. |:
Zfish   643 LFQAKRCFRLAPTFSNVLLRPATTTPPAPELNPAPVQEITPPTGETPRNTSPEIANGTNDKD-PD 706

  Fly   557 ED----------------------FATVNTYLQFVNVYVRWLSISLDVWEPVRSEEHSFIDCWAE 599
            .|                      ..|....:|.|.|::.||..:.|:.........|.   |..
Zfish   707 SDSEGSEHSNHSFHSEKTLSERLEILTNQGLIQVVKVFLDWLRTNTDIILMCAQSSQSL---WNR 768

  Fly   600 LTILFEYI----------------------ECLMGKHKLEKNEILLDEDVALRGFTPLGRETLSM 642
            |::|...:                      ||   :|......:||.||||||....|......:
Zfish   769 LSVLLNLLPEGSKILETDIGLNKDVTELLSEC---EHPSLAQTLLLPEDVALRHLPALSVAHRCL 830

  Fly   643 DYLKRGSERLQFFERVRRIGQFQEYYVQHQEALQQPLESSFTVEHLNAAMKNALENYDAESCGLA 707
            |:..:........|.|.|:...:.:                  .|....::..:.:::.|: |:.
Zfish   831 DFTSQRPPLTPLDECVVRVCCIRSF------------------GHFLTNLQGNVLHFNPEA-GIF 876

  Fly   708 ANVS-----------KIQCKAVEELLCRSTDSDVSELCKLKKELEAKARVKQICTSKLEDILKFV 761
            .::|           |.|.:..||...|  :..:.::.:|:.:||         .|:||..|:
Zfish   877 TSISQSEQDNLVQQAKAQFRMAEEEARR--NRLMRDMAQLRLQLE---------VSQLEGSLQ-- 928

  Fly   762 DTKIYIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRYTLIIPLTVVKELDGLSKGVKLDSYRSSK 826
            ..|....:.| ||:|||......|....:|:.. ..:.:|||.||:..||.|.|
Zfish   929 QPKAQSSMSP-YLVPDTAVLCQHLGLLRQLAAS-GCFIIIIPRTVIDGLDMLKK----------- 980

  Fly   827 QTQRIHHFDEVSSRAKKSLEFIKS--AKGN--VKCATTKG-SFVNASVFALVEEEYLSNDDKILA 886
                      .:|.|:..:.|:::  .|||  ::|....| ||         |.:.|...|   .
Zfish   981 ----------ENSGARDGIRFLETEFRKGNRYIRCQKESGRSF---------ERDKLKRQD---T 1023

  Fly   887 TAMAVSKTAKT-----------EQCTDGKCFIQT-----ELVLITTDRNLRVKALSRNLAVSALD 935
            .|..:.||..:           ::.|.|...|.|     ||    ::|:..:||..:.:|.:.::
Zfish  1024 EAWHLYKTVDSCRQLTGSQSSGDEDTAGMVTILTGHSLEEL----SERSASMKAAVQAVAAAGME 1084

  Fly   936 -----EFL-QW 940
                 ||. ||
Zfish  1085 LKNIIEFYRQW 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	190..298	CDD:287360	31/153 (20%)
		EST1_DNA_bind	310..638	CDD:287359	94/645 (15%)
		P-loop_NTPase	<616..>769	CDD:304359	30/163 (18%)
		PIN_Smg6	767..941	CDD:189055	47/201 (23%)
smg5	NP_001020094.1	EST1	74..184	CDD:287360	23/113 (20%)
		EST1_DNA_bind	194..>413	CDD:287359	45/225 (20%)
		PIN_Smg5	938..1096	CDD:189054	47/197 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900