DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg6 and smg7

DIOPT Version :9

Sequence 1:	NP_651321.1	Gene:	Smg6 / 42994	FlyBaseID:	FBgn0039260	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	XP_012816221.1	Gene:	smg7 / 394870	XenbaseID:	XB-GENE-955255	Length:	1193	Species:	Xenopus tropicalis

Alignment Length:	794	Identity:	170/794 - (21%)
Similarity:	270/794 - (34%)	Gaps:	253/794 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 LQDAFKQLLLEQLKFVCEHKVDVFFWKLLFYNVRNYLKRQ-------QTDQAHTHTLLLIEQAIK 257
            |||.::::|:..|::..:.||:...|...|.|....|:.|       ...:...:..|.:|.|..
Frog    36 LQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRTNPNRSEVQANLSLFLEAASG 100

  Fly   258 FYRMLYDKLMA------KC-VASSRC-----------------DSALKVVAQRLLICLGDLTRYR 298
            ||..|..:|..      .| |.||:.                 .|:...:.|..|:.|||:.|||
Frog   101 FYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQMHSGTVVKPQSSSCAYICQHCLVHLGDIARYR 165

  Fly   299 VNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKE 363
                  ....:|..||:.|.:|||.||.|:||||:::.........::||.||:.......:|..
Frog   166 ------NQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAAST 224

  Fly   364 SLLDLFDEIRRKYEETEMKQSPMHYAAGSKNQKSKQMRKEVWIYPDGIRRLHRTDDKGNKAKGNK 428
            :|                      ..|.||..:|::..|..|...|
Frog   225 NL----------------------QKALSKALESREEVKNRWGVSD------------------- 248

  Fly   429 ATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTDVDSLYPLLRKLQIQIGVALRHENLLSRS 493
                                .:..::...|.:|....::.:..|..:|:.|. ..|..:..|:..
Frog   249 --------------------FIKAFIKFHGHVYLTKSLEKVSTLREQLEEQF-KNLLFQKALNSQ 292

  Fly   494 KLLKIVALNLFVVEHNKPKTSRREMRYHSFN------------FANSFFGLMMK---KTNQLLAG 543
            :|:.|..:|||.:.|  .::...|....||:            ...||.|::.:   ||:.
Frog   293 QLVHITVINLFQLHH--LRSFGTEADQQSFSPEEELCWSQLLALFMSFLGILCRFPLKTHH---- 351

  Fly   544 FVEDSTNVQCLPEEDFATVNTYLQFVNVYVRWLSISLDVWEPVRSEEHSFIDCWAELTILFEYIE 608
             .|:::....||.            :.|.:.|:.:...|::....||..::..|        .|.
Frog   352 -CEETSCANPLPA------------IKVSLDWMKLRPSVFQENTVEEKKYVWPW--------LIS 395

  Fly   609 CLMGKHKLEK-----NEILLDEDVALRGFTPLGRETLSMDYLKRGSERLQFFERVRRIGQFQEYY 668
            .|...|.|::     |.:.|.|:..|:||..|.....::|: .||.   |....||.
Frog   396 LLNSFHVLDEDVSSANMLPLPEEFELQGFLALRPAFRNLDF-SRGH---QAITGVRD-------- 448

  Fly   669 VQHQEALQQPLESSFTVEHLNAAMKNALENYDAESCGLAANVSKIQCKAVEELLCRSTD------ 727
            .||::.  :||       .|.|..|...||          ....||.:.||..|...||
Frog   449 AQHRQL--RPL-------RLAAVGKWISEN----------QPQLIQYRTVEGELLFFTDIPELLT 494

  Fly   728 SDVSELCKLKKELEAKARVKQICTSKLEDI--LKFVDTKIYIEVRPRYLLPDTNCFIDCLEDFEK 790
            .|:.|    .::..:.....|..|.|.|..  ||.|.:      ..|.|..|||         ||
Frog   495 EDIDE----TEDRSSPQEFNQTDTHKAEGSPGLKSVLS------TGRSLSCDTN---------EK 540

  Fly   791 LSTEFKRYTLIIPLTVVKELDGLSKGVKLDSYRSSKQTQRIHHFDEVSSRAKKSLEFIKSAKGNV 855
            ....||..        :|..: |::.|...||..|                           |||
Frog   541 PVVTFKEN--------IKPQE-LNRDVPSRSYTRS---------------------------GNV 569

  Fly   856 KCATTKGSFVNASVFALVEEEYLSNDDKILATAMAVSKTAKTEQCTDGKCFIQTELVLITTDRNL 920
              |..:..: |.|:...|.::..:|..|.....|.|.|||:     .||   |:..|.:.:...|
Frog   570 --AKDQRDY-NKSLNNAVNKKDNNNKRKNELKKMCVEKTAE-----PGK---QSIAVQVKSQTEL 623

  Fly   921 RVKALS--RNLAVS 932
            |...:|  |..||:
Frog   624 RKTPVSEARKTAVT 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	190..298	CDD:287360	30/128 (23%)
		EST1_DNA_bind	310..638	CDD:287359	68/347 (20%)
		P-loop_NTPase	<616..>769	CDD:304359	39/165 (24%)
		PIN_Smg6	767..941	CDD:189055	39/168 (23%)
smg7	XP_012816221.1	EST1	55..167	CDD:287360	27/117 (23%)
		TPR repeat	154..180	CDD:276809	11/31 (35%)
		EST1_DNA_bind	171..431	CDD:287359	68/348 (20%)
		TPR repeat	185..215	CDD:276809	11/29 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D556396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920