Protein Alignment Smg6 and Smg5

DIOPT Version :10

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_609685.1
• Gene: Smg5 / 34804
• FlyBaseID: FBgn0019890
• Length: 1177
• Species: Drosophila melanogaster
• Alignment Length: 851
• Identity: 171/851 - (20%)
• Similarity: 286/851 - (33%)
• Gaps: 243/851 - (28%)

  Fly   189 NWKNFCYIHDQLQD-AFKQLLLEQL-KFVCEHKVDVFFWKLLFYNVRNYLKRQQTDQAHTHTL-- 249
            ||      |.|.|| |..|..:::| :|:|.             .:.|| ||........:.|
  Fly   119 NW------HKQCQDAATAQENMQKLERFLCA-------------GIFNY-KRLSARMEEIYDLDL 163

  Fly   250 -LLIEQAI----KFYRMLYDKLMAKCVASSRCDSALKVVAQRL------LICLGDLTRY----RV 299
             .||:.:|    ....|:.|.:.:....:...|.:|:.|:..|      |:.||||.||    |:
  Fly   164 KYLIDFSIISDGYISDMIGDTMESSHSGTHAVDKSLEAVSFALDTIHSSLLSLGDLHRYFLDFRI 228

  Fly   300 NHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKES 364
            :...:....:.|:||..|.:|.|..|...|||..:....:...|:.|:|:.||:.....:.::.:
  Fly   229 DSKLSISKEQVAKYYLEAFKLNPAIGMAQNQLGTLHYGQNHDLDSTYHYLYSLVCIIPFELSENN 293

  Fly   365 LLDLFDEIRRKYEETEMKQSPMHYAAGSKNQKSKQMRKEVWIYPDGIRRLHRTDDKGNKAKGNKA 429
            |..||
  Fly   294 LNKLF------------------------------------------------------------ 298

  Fly   430 TMAEVNRY-EEMPPEEILPRIVSLY--LYLLGKL-YTGTDVDSLYPLLRKLQIQIGVALRHENL- 489
              |:...| |.|.||::...|...:  .||:..: :...:|.....|...:.|.:...|..:.|
  Fly   299 --AKHTEYLERMDPEKLDFNIEDFFARFYLIVDIFFFDKEVPDFNALCHCVLIDLRKILCSQQLR 361

  Fly   490 LSRSKLLKIVALNLFVVEHNKPKTSRREMRYHSFNFA--NSFFGLMMKKTNQLLAGFVEDSTNVQ 552
            :....:.|||::..|.:...|...|.:....|:|..|  :......:....|.:....:|:...|
  Fly   362 VPEPSIFKIVSILFFCLSKLKMINSPKVYSLHAFLVAACSDLMDACIVSIEQTILARAQDNERFQ 426

  Fly   553 CLPEEDFATVNTYL-QFVNVYVRWLSISLDVWEPVRSEE------HSFIDCWAELTILFEYIECL 610
            ...||.|...:|.: :..|.|..||:.   |.|..|.::      ||..||.:         :..
  Fly   427 AEYEERFQEFDTVVRKSRNEYKNWLAA---VGECERKDKKLMPRPHSLKDCSS---------DSR 479

  Fly   611 MGKHKLE--KNEILLDED-----VALRGF---------TPLGRETLSMDYLKRGSERLQFFERVR 659
            ..:|..|  |.:...|.|     |:.|..         |||..::      ||...||:  .|.|
  Fly   480 DSQHSGEEAKTQEAADGDKIGEAVSTRSSDEAKESDLKTPLSCKS------KRRGMRLR--RRRR 536

  Fly   660 RIGQFQEYYVQHQEALQQPLESSFTVEH-----LNAAMKNALENYDA----ESCG----LAANVS 711
            :|.|..:......|:   .|::.|..:.     |::.......:.||    |.||    .|||.|
  Fly   537 KIAQSDDSSCYDSES---ELDTDFYSDEEDYTDLSSNFDTDFSDIDAADPGEPCGEERYAAANYS 598

  Fly   712 KIQCKA--------------------VE----------ELLCRSTDSDVSELCKLKKELEAKARV 746
            |.:.||                    :|          |....|.::|..||.:..:.|:...:.
  Fly   599 KKERKAGGGGGGGVGGVVYSDNEDVVIEEEKIVYPNEVERRSNSQEADSEELLRSFEVLQLNFKS 663

  Fly   747 KQICTSK---------LEDILKFVDTKIYIEVRPRYLLPDTNCFIDCLED---FEKLSTEFKRYT 799
            .:...||         .|...|.|....|.::.|       |..||||.:   ...|...|. :.
  Fly   664 AEDAQSKPVAPPPVSFSEPPKKLVYRNKYTKINP-------NIVIDCLHNEPTIRALKMLFD-WL 720

  Fly   800 LIIPLTVV----KELDGLSKGVKLDSYRSSKQTQRIHHFDE---VSSRAKKSLEFIKSAKGNVKC 857
            .|.|..::    ...:.:.|.:||.:|.:.....|..:|:.   .::..:.||..:...:.||.
  Fly   721 RINPEILIGCYHSNPEFVHKIMKLLNYCNIDIFTRKVYFERDLLTTANVRDSLVELFDVRANVP- 784

  Fly   858 ATTKGSFVNASVF----------ALVEEEYLSNDDKILATAMAV--------SKTAKTEQCTDGK 904
            .|...:|.|..:|          .::.|.....::.||.....|        .|......|...:
  Fly   785 LTEDFAFKNFDIFQSTQITLDWETIIRERVTPQEESILRIFKMVDFGFFICKQKKFNYRFCVKTR 849

  Fly   905 CFIQTE 910
            .|.:|:
  Fly   850 RFTETQ 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	219..298	CDD:463062	21/95 (22%)
		EST1_DNA_bind	310..639	CDD:431239	69/358 (19%)
		PIN_Smg6-like	767..941	CDD:350233	32/172 (19%)
Smg5	NP_609685.1	EST1	99..227	CDD:463062	32/127 (25%)
		EST1_DNA_bind	240..479	CDD:431239	59/312 (19%)
		MSCRAMM_ClfA	<470..>580	CDD:468110	25/129 (19%)
		PIN_Smg5-like	1012..1173	CDD:350232