DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Smg6 and CG7206

DIOPT Version :9

Sequence 1:	NP_651321.1	Gene:	Smg6 / 42994	FlyBaseID:	FBgn0039260	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_996499.1	Gene:	CG7206 / 32788	FlyBaseID:	FBgn0030892	Length:	404	Species:	Drosophila melanogaster

Alignment Length:	355	Identity:	85/355 - (23%)
Similarity:	135/355 - (38%)	Gaps:	91/355 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   617 EKNEILLDEDVALRGFTPLGRETLSMDYLKRGSERLQFFERVRR--IGQFQEYYVQHQ-EALQQP 678
            ||.:.|:|.:....|.|....:.|.:  |:...::.|.:|....  :.:..|..::.| ||....
  Fly   102 EKPKALVDANRLKAGRTQTAYQRLML--LRASLQQKQLYEERNNNIVAKINEEVIEKQPEACNIT 164

  Fly   679 LESSF---TVEHLNAAMKNALENYDAESCGLAANVSKIQCKAVEELLCRSTDSDVSELCKLKKEL 740
            ..|:|   |...:........|:.:.|    ||...:.:.|..::.|.......:.|....|.:.
  Fly   165 NPSAFDGSTASDMEVEPMEWQESIEEE----AAQNDQDEAKKGDDTLLMLPAESIEEEAPQKGQD 225

  Fly   741 EAKARVKQICTSKLEDILKFVDTKIYIEVRPR-----YLLPDTNCFIDCLEDFEKLSTEFKRYT- 799
            |||.....|.      :|:..|.:   |:.||     |.:.|||..|...:..|:|:......|
  Fly   226 EAKEEDDTIL------MLQAADAE---ELPPRLEDYMYFVLDTNVLIHNHKFVERLTDVVLPGTV 281

  Fly   800 ---LIIPLTVVKELDGLSKGVKLDSYRSSKQTQRIHHFDEVSSRAKKSLEFIKSAKGNVKCATTK 861
               |.:|..|:||||      ||.|...|...||:     ::.||             ::...||
  Fly   282 GSMLYLPYIVIKELD------KLKSKYQSDCLQRV-----IAMRA-------------IRFLNTK 322

  Fly   862 --GSFVNASVFALVEEEYLSN----DDKILATAMAVSKTAKTEQCTDGKCFIQTE-----LVLIT 915
              .||...:..||.|.::|..    ||.||                  .|.:|.:     ::|:|
  Fly   323 FDESFQIQAQSALEEADHLIKIDCPDDSIL------------------NCCLQLQAQVPHMILLT 369

  Fly   916 TDRNLRVKALSRNLAVSA--------LDEF 937
            .|.|||:||.:.|:.||.        :|||
  Fly   370 NDANLRLKANASNIQVSCRSDLMSTYVDEF 399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	190..298	CDD:287360
		EST1_DNA_bind	310..638	CDD:287359	6/20 (30%)
		P-loop_NTPase	<616..>769	CDD:304359	31/157 (20%)
		PIN_Smg6	767..941	CDD:189055	54/199 (27%)
CG7206	NP_996499.1	PIN_Smg5-Smg6-like	254..392	CDD:189050	48/179 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1427
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030