DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg6 and Smg6

DIOPT Version :9

Sequence 1:	NP_651321.1	Gene:	Smg6 / 42994	FlyBaseID:	FBgn0039260	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_001099278.1	Gene:	Smg6 / 287522	RGDID:	1595918	Length:	1472	Species:	Rattus norvegicus

Alignment Length:	919	Identity:	233/919 - (25%)
Similarity:	411/919 - (44%)	Gaps:	177/919 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 SPVTRTRLTTEHPDWFEPLLGLPHAKNI--VHLYDQLMVLNQRNLILIN-----------WKNFC 194
            ||:..:.::.|..:        .|.:|:  ..|:..|.|.:.:.|.|.|           .:...
  Rat   610 SPLPASTMSPEEIE--------QHVRNMQQQELHRLLRVADNQELQLSNLLSRDRISTEGMEKMA 666

  Fly   195 YIHDQLQDAFKQLLLEQLKFVCEHKVDVFFWKLLFYNV----RNYLKR---QQTDQAHTHTLLLI 252
            .:..:|...:::.:|..::|.....||...||..||.|    |..||.   :..:|.....|.|:
  Rat   667 QLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNIENPEQIRNRLLELL 731

  Fly   253 EQAIKFYRMLYDKLMAK------------CVASSRCDSALK---VVAQRLLICLGDLTRYRVNHV 302
            ::...|:..|..||...            .:.|......:|   :.|||.:||.||::|||....
  Rat   732 DEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQAN 796

  Fly   303 KATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKESLLD 367
            ...:|.:|..:|.:||.:.|.||.|:||||::::|..::.||||||:|||..||.|.:|||||:.
  Rat   797 DTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMS 861

  Fly   368 LFDEIRRKYEETEMKQ------SPMHYAAGSKNQ----KSKQMRKEVWIYPDGIRRLHRTDDKGN 422
            ||:|.:||.|:.|.||      ||..:..|.|:.    .....|.|:||:|.     |....:|.
  Rat   862 LFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPS-----HSRSSQGT 921

  Fly   423 KAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTDVDSLYPLLRKLQIQIGVALRHE 487
            ::  .|.:..| |....:.|.::..|.:..:|:..|||:|...:::...:..|:..:..|.|:|.
  Rat   922 ES--GKDSEQE-NGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHS 983

  Fly   488 -NLLSRSKLLKIVALNLFVVEHNKPK-----TSRREMRYHSFNFANSFFGLMMKKTNQLLAGFVE 546
             :.:..:::|:::.:|:|.|.:::.|     ..|..::..:.:...:.|.|::::...||    :
  Rat   984 PSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAASLGLAMFSLLVQRCTCLL----K 1044

  Fly   547 DSTNVQCLPEED------------FATVNTYLQFVNVYVRWLSISLDVWEPVRSE----EHSFID 595
            ||...|....||            ...:...|..|.|:..|:....|.|.|..:.    ....:|
  Rat  1045 DSAKAQLSSPEDQEDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPLQVAVD 1109

  Fly   596 CWAELTILFEYIECLMGKHKLE----KNE------ILLDEDVALRGFTPLGRETLSMDYLKRGSE 650
            .|:.|.   ::...|...::.|    |:.      ::|:||..|.||.||........|:::.|:
  Rat  1110 VWSTLA---DFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSD 1171

  Fly   651 RL--QFFERVRRIGQFQEYYVQHQEAL--------------------------QQPLESSFTVEH 687
            ::  ...:||..:..|.|.....:|.|                          .:.||.    |.
  Rat  1172 KVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGIQEGKQLED----EE 1232

  Fly   688 LNAAMKNALENYDAESCGLAANVSKIQCKAVEELLCRSTDSDVSELCKLKKELEAKARVKQICTS 752
            .:..:::..|:.:||..|...::.:::.|.:  .|.|..........|::..||.:::::|
  Rat  1233 EDVVIEDFEEDSEAEGSGGEDDIRELRAKKL--ALARKIAEQQRRQEKIQAVLEDQSQMRQ---- 1291

  Fly   753 KLEDILKFVDTKIYIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRYTLIIPLTVVKELDGLSKGV 817
                        :.:|:||.:|:||||.|||.|....:| .|.::|.|::||.|:.|||||:||.
  Rat  1292 ------------MELEIRPLFLVPDTNGFIDHLASLARL-LESRKYILVVPLIVINELDGLAKGQ 1343

  Fly   818 KLDSYRSSKQTQRIHHFDEVSSRAKKSLEFI----KSAKGNVKCATTKGSFVNASVFAL--VEEE 876
            :.| :|:....:      .|..:|:||:||:    :|....::..|::|:.:.:..|..  :..:
  Rat  1344 ETD-HRAGGYAR------VVQEKARKSIEFLERRFESRDSCLRALTSRGNELESIAFRSEDITGQ 1401

  Fly   877 YLSNDDKILATAMAVSK--------TAKTEQCTDGKCFIQTELVLITTDRNLRVKALSRNLAVSA 933
            ..:|||.||:..:...|        |:|.|...     :..|:||:|.|||||||||:||:.|..
  Rat  1402 LGNNDDLILSCCLHYCKDKAKDYMPTSKEEPIR-----LLREVVLLTDDRNLRVKALTRNVPVRD 1461

  Fly   934 LDEFLQWAK 942
            :..||.||:
  Rat  1462 IPAFLTWAQ 1470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	190..298	CDD:287360	30/129 (23%)
		EST1_DNA_bind	310..638	CDD:287359	100/369 (27%)
		P-loop_NTPase	<616..>769	CDD:304359	32/190 (17%)
		PIN_Smg6	767..941	CDD:189055	65/187 (35%)
Smg6	NP_001099278.1	EST1	691..794	CDD:287360	35/124 (28%)
		EST1_DNA_bind	804..1156	CDD:287359	99/421 (24%)
		TPR repeat	818..848	CDD:276809	16/29 (55%)
		TPR repeat	853..876	CDD:276809	6/26 (23%)
		PIN_Smg6	1294..1469	CDD:189055	39/130 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337142
Domainoid	1	1.000	127	1.000	Domainoid score	I5269
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	243	1.000	Inparanoid score	I3231
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D365748at33208
OrthoFinder	1	1.000	-	-		FOG0006417
OrthoInspector	1	1.000	-	-		oto98324
orthoMCL	1	0.900	-	-		OOG6_107730
Panther	1	1.100	-	-	LDO	PTHR15696
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5372
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760