DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg6 and SPCC24B10.15

DIOPT Version :9

Sequence 1:	NP_651321.1	Gene:	Smg6 / 42994	FlyBaseID:	FBgn0039260	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_001342947.1	Gene:	SPCC24B10.15 / 2538887	PomBaseID:	SPCC24B10.15	Length:	465	Species:	Schizosaccharomyces pombe

Alignment Length:	574	Identity:	111/574 - (19%)
Similarity:	191/574 - (33%)	Gaps:	172/574 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 KSGNSARRRGRKDKEH----------ATQSP-----VTRTRLTTEHPDWFEPLLGLPHAKNIVHL 173
            :|.||.|.|.|....|          :.|||     .:.|.|.::...:.:||
pombe    17 ESINSERARNRWSTSHIPSLSEINPSSFQSPSPSPFASSTSLASKPARYSKPL------------ 69

  Fly   174 YDQLMVLNQRNLILINWKNFCYIHDQLQDAFKQLLLEQLKFVCEHKVDVFFWKLL---------F 229
              .|.||:         .||...|..|    .|.|:|.|...|...|.|..|.:|         .
pombe    70 --GLFVLD---------TNFLLSHLSL----CQNLIEFLTARCPRLVVVLPWTVLQELDGLKSES 119

  Fly   230 YNVRNYLKRQQTDQAHTHTLLLIEQAIKFYRMLYDKLMAKCVASSRCDSALKVVAQRLLICLGDL 294
            .:...||.|    |||...|......:...|  ..|:...|.::.:.|.|:
pombe   120 SSTCGYLAR----QAHNFLLQCFRSNVSSLR--GQKVHEHCSSTEKGDDAI-------------- 164

  Fly   295 TRYRVNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQ 359
                         ::...|||. ::|:|.        .::|...:....|..::::||..|..::
pombe   165 -------------LDCCIYYQE-EKLIPA--------VLLSDDKNLSIKAAVHHIQSLSFSKGLE 207

  Fly   360 SA---KESLLDLFDEIRRKYEETEMK-----QSPMHYAAGSKNQKSKQMRKEVWIYPDGIRRLHR 416
            :|   :.|....|.......|...|.     ..|:..|...:||.:..:.     .|     :.|
pombe   208 AASIVQTSFPSAFSSNSENLENLSMDIDLTVSQPLATATNHRNQGASTVD-----IP-----MDR 262

  Fly   417 TDDKGNKAKGNKATMAEVNRYEEMPP---EEILPRIVSLYL-YLLGKLYTGTDVDSLYPLLRKLQ 477
            |.|....|          :||...||   ::...|..:.|: |....|.....:.:.:|...||.
pombe   263 THDNSIWA----------SRYAHFPPYDKKKDTTRSAADYIPYTYTALTKEEILHASHPRACKLL 317

  Fly   478 IQIGVALRHEN--LLSRSKLLKI-----VALNLFVVEHNKPKTSRREMRYHSF-NFANSFFGLMM 534
            .||...:..|.  |||| .|||:     :|:...:.....|..:..::.:..: ::...|.|.
pombe   318 DQITKIMVEETAFLLSR-HLLKLWGDYDLAMTKLLASPQFPPQNINDVGHELYIHWYTCFDGY-- 379

  Fly   535 KKTNQLLAGFVEDSTNVQCLPEEDFATVNTYLQFVNVYVRWLSISLDVWEPVRSEEHSFIDCWAE 599
                               ||.::.:.:.:..:..|.::.|....:.:....:.|..:::..|:.
pombe   380 -------------------LPAQERSNLKSKAELWNEWMLWAERGIGIGPKNQEELQTYVTFWSN 425

  Fly   600 LTILFEYIECLMGKHKLEKNEILLDEDVALRGFTPLGRETLSMDYLKR-GSERL 652
            :..|            |.:.|||.|:.....||    ||.....:::| |.||:
pombe   426 IWTL------------LSRREILGDQASTYIGF----REQNIEKWVERSGRERI 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	190..298	CDD:287360	25/116 (22%)
		EST1_DNA_bind	310..638	CDD:287359	63/347 (18%)
		P-loop_NTPase	<616..>769	CDD:304359	13/38 (34%)
		PIN_Smg6	767..941	CDD:189055
SPCC24B10.15	NP_001342947.1	PIN_Smg5-Smg6-like	71..208	CDD:189050	38/191 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1427
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030