DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Smg6 and SMG5

DIOPT Version :9

Sequence 1:	NP_651321.1	Gene:	Smg6 / 42994	FlyBaseID:	FBgn0039260	Length:	948	Species:	Drosophila melanogaster
Sequence 2:	NP_056142.2	Gene:	SMG5 / 23381	HGNCID:	24644	Length:	1016	Species:	Homo sapiens

Alignment Length:	1113	Identity:	211/1113 - (18%)
Similarity:	341/1113 - (30%)	Gaps:	450/1113 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 PHAKNIVH---LYDQLM-VLNQRNLILINWKNFCYIHDQLQDAFKQ---LLLEQLKFVCE----- 217
            |.|| ::|   ||..:: .:::.:|||.|...:       |:.||.   .|..:|:.:|.
Human    13 PEAK-VLHTKRLYRAVVEAVHRLDLILCNKTAY-------QEVFKPENISLRNKLRELCVKLMFL 69

  Fly   218 HKVDV------FFWKLLFYNVRNYLKRQQTDQAHTHTLLLIEQA--------IKFYRML------ 262
            |.||.      ..|:.::|.|...:|   |::.|.|:...:|.|        |.||:.|
Human    70 HPVDYGRKAEELLWRKVYYEVIQLIK---TNKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQS 131

  Fly   263 -YDKLMAKCV-----------------ASSRCDSALKVVAQRLLICLGDLTRYRVNHVKATD-YM 308
             |...:..|:                 ||.:.....::...|.|:.||||:||: |.:...| .:
Human   132 HYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGDLSRYQ-NELAGVDTEL 195

  Fly   309 EAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKESLLDLFDEIR 373
            .|.|:|.:|..:.|..|.|||||..::...:...:|:|.|:|.:.:..|.:.|..:|..|:|:..
Human   196 LAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAA 260

  Fly   374 RKYEETE----MKQSP-----------------------------------------------MH 387
            :.|.:.:    .|.||                                               :.
Human   261 KMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLF 325

  Fly   388 YAAGSKN-----QKSKQMRKEVWIYPD---------GIRRLHRTDDKGNKAKG------------ 426
            |...|.|     :..::........||         .:..:|..:..|:|...
Human   326 YLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVIICLMCVHSLERAGSKQYSAAIAFTLALFSH 390

  Fly   427 -----NKATMAE------------------------VNRYEEMPPE--EILPRIVSLYLYLLGK- 459
                 |....||                        |.:.||..||  .:.|::..      |:
Human   391 LVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGE------GRK 449

  Fly   460 ------------------------LYTGTDVDSLYPLLR----------KLQIQIGVALRHE--- 487
                                    |..|.:.||.:...|          |.....|.|...|
Human   450 SRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDS 514

  Fly   488 ---NLLSRSKLLKI----------------------------------VALNLFVVEHNKPKTSR 515
               :..|||.|..:                                  :|.||..:.....:|.|
Human   515 EMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKR 579

  Fly   516 REMRYHSFNFANSFFGLMMKKTNQ---------LLAGFVE----------------DSTNVQCLP 555
                  .|..|.:|..|:::.|..         .:.|.|:                :|:...|..
Human   580 ------CFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRN 638

  Fly   556 EEDFATVNTYLQF---------VNVYVRWLSISLDVWEPVRSEEHSFIDCWAELTILFEYIE--- 608
            |.   ::...||.         |.|::.||..:.|:.........|.   |..|::|...:.
Human   639 ER---SIQEKLQVLMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSL---WNRLSVLLNLLPAAG 697

  Fly   609 ---------CLMGKHKLE-------KNEILLDEDVALRGFTPL-----------GRETLSMDYLK 646
                     |...:..||       .:.:||.||:|||...||           .|..||.  |:
Human   698 ELQESGLALCPEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLST--LE 760

  Fly   647 RGSERL-------QFFERVR--------RIGQFQEYYVQHQEALQQPLESSFTVEHLNAAMKNAL 696
            ....|:       .|..|::        .:|.|.......||:|.|..::.|.:.. ..|.:|.|
Human   761 ESVVRICCIRSFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQ-EEARRNRL 824

  Fly   697 ENYDAESCGLAANVSKIQCKAVEELLCRSTDSDVSELCKLKKELEAKARVKQICTSKLEDILKFV 761
                                             :.::.:|:.:||         .|:||..|:
Human   825 ---------------------------------MRDMAQLRLQLE---------VSQLEGSLQ-- 845

  Fly   762 DTKIYIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRYTLIIPLTVVKELDGLSKGVKLDSYRSSK 826
            ..|....:.| ||:|||......|....:|:|. .|:.:|||.||:..||.|.|
Human   846 QPKAQSAMSP-YLVPDTQALCHHLPVIRQLATS-GRFIVIIPRTVIDGLDLLKK----------- 897

  Fly   827 QTQRIHHFDEVSSRAKKSLEFIKS--AKGN--VKCATTKG-SFVNASVFALVEEEYLSNDDKILA 886
                 .|     ..|:..:.::::  .|||  ::|....| ||         |...|...|....
Human   898 -----EH-----PGARDGIRYLEAEFKKGNRYIRCQKEVGKSF---------ERHKLKRQDADAW 943

  Fly   887 TAMAVSKTAKT--------EQCTDGKCFIQTELVLITTDRNLRVKALSRNLAVSA---------- 933
            |...:..:.|.        |:...|...|.|.|.|    .|..|.:.....|:.|
Human   944 TLYKILDSCKQLTLAQGAGEEDPSGMVTIITGLPL----DNPSVLSGPMQAALQAAAHASVDIKN 1004

  Fly   934 -LDEFLQW 940
             ||.:.||
Human  1005 VLDFYKQW 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	190..298	CDD:287360	33/153 (22%)
		EST1_DNA_bind	310..638	CDD:287359	93/574 (16%)
		P-loop_NTPase	<616..>769	CDD:304359	36/185 (19%)
		PIN_Smg6	767..941	CDD:189055	47/198 (24%)
SMG5	NP_056142.2	EST1	77..187	CDD:287360	25/113 (22%)
		TPR repeat	172..206	CDD:276809	14/34 (41%)
		EST1_DNA_bind	197..>412	CDD:287359	35/214 (16%)
		TPR repeat	211..241	CDD:276809	10/29 (34%)
		TPR repeat	246..268	CDD:276809	5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..561		20/158 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	594..637		4/42 (10%)
		PIN_Smg5	855..1013	CDD:189054	47/194 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900