DRSC/TRiP Functional Genomics Resources

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Protein Alignment Smg6 and SMG6

DIOPT Version :10

Sequence 1:NP_651321.1 Gene:Smg6 / 42994 FlyBaseID:FBgn0039260 Length:948 Species:Drosophila melanogaster
Sequence 2:NP_060045.4 Gene:SMG6 / 23293 HGNCID:17809 Length:1419 Species:Homo sapiens


Alignment Length:1130 Identity:267/1130 - (23%)
Similarity:451/1130 - (39%) Gaps:287/1130 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 TTTKALETENAENAEPVATTA----NASRPVEILSNASTGGGKPDAQSKQPVLDTSGKMAWEGGI 99
            |.....:.|......|:..:|    :..:|.:.||  |.|.|....:||.|      |....|..
Human   349 TLRVTFDAEAMNKESPMVRSARDDMDRGKPDKGLS--SGGKGSEKQESKNP------KQELRGRG 405

  Fly   100 PGILRVTTSVAGDVNRNGQGQ----------GKNKSGNSARRRG---RK--DKEHATQSPVTRTR 149
            .|||.:.......||..|..:          |....|:.:..||   |:  |..:..|.|..:|:
Human   406 RGILILPAHTTLSVNSAGSPESAPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKTQ 470

  Fly   150 LTTEH----------PDW------------------------------------FEPLL------ 162
            ....|          ..|                                    :.||.      
Human   471 TPQLHFLDTDDEVSPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYTGYNPLQYPVGPT 535

  Fly   163 ----------GLP-----------------------HAKNI--VHLYDQLMVLNQRNLILIN--- 189
                      |.|                       |.:|:  ..|:..|.|.:.:.|.|.|   
Human   536 NGVYPGPYYPGYPTPSGQYVCSPLPTSTMSPEEVEQHMRNLQQQELHRLLRVADNQELQLSNLLS 600

  Fly   190 --------WKNFCYIHDQLQDAFKQLLLEQLKFVCEHKVDVFFWKLLFYNV----RNYLKR---Q 239
                    .:....:..:|...:::.:|..::|.....||...||..||.|    |..:|.   :
Human   601 RDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVE 665

  Fly   240 QTDQAHTHTLLLIEQAIKFYRMLYDKLMAK------------CVASSRCDSALK---VVAQRLLI 289
            ..:|.....|.|:::...|:..|..||...            .:.|......:|   :.|||.:|
Human   666 NPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMI 730

  Fly   290 CLGDLTRYRVNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLT 354
            |.||:.|||.......:|.:|..:|.:||.:.|.||.|:||||::::|..::.||||||:|||..
Human   731 CQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAA 795

  Fly   355 SNSIQSAKESLLDLFDEIRRKYEETEMKQ------SPMHYAAGSKNQ----KSKQMRKEVWIYPD 409
            ||.|.:|||||:.||:|.:||.|:.|.||      ||..:..|.|:.    .....|.|:||:|.
Human   796 SNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPS 860

  Fly   410 GIRRLHRTDDKGNKAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTDVDSLYPLLR 474
                 |....:|.::  .|.:..| |....:.|.::..|.:..:|:..|||:|...:::...:..
Human   861 -----HPRSSQGTES--GKDSEQE-NGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAE 917

  Fly   475 KLQIQIGVALRHE-NLLSRSKLLKIVALNLFVVEHNKPK-----TSRREMRYHSFNFANSFFGLM 533
            |:..:..|.|:|. :.:..:::|:::.:|:|.|.:::.|     ..|..::..:.....:.|.|:
Human   918 KVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAAALGLAMFSLL 982

  Fly   534 MKKTNQLLAGFVEDSTNVQCLPEED------------FATVNTYLQFVNVYVRWLSISLDVWEPV 586
            :::...||    ::|...|....||            ...:...|..|.|:..|:....|.|.|.
Human   983 VRRCTCLL----KESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPP 1043

  Fly   587 RSE----EHSFIDCWAELTILFEYIECLMGKHKLE----KNE------ILLDEDVALRGFTPLGR 637
            .:.    .|..:|.|:.|.   ::...|...::.|    |:.      ::|:||..|.||.||..
Human  1044 PTSLDLPSHVAVDVWSTLA---DFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLA 1105

  Fly   638 ETLSMDYLKRGSERL--QFFERVRRIGQFQEYYVQHQEAL----------QQPLESS-------- 682
            ......|:::.|:::  ...:||..:..|.|.....:|.|          ..|:..:        
Human  1106 APQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQ 1170

  Fly   683 ----FTVEHLNAAMKNALENYDAESCGLAANVSKIQCKAVEELLCRSTDSDVSELCKLKKELEAK 743
                ...|..:..:::..|:.:||..|                    .:.|:.||...|..|..|
Human  1171 EGTRLEDEEEDVVIEDFEEDSEAEGSG--------------------GEDDIRELRAKKLALARK 1215

  Fly   744 ARVKQICTSKLEDILKFVD----TKIYIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRYTLIIPL 804
            ...:|....|::.:|:  |    .::.:|:||.:|:||||.|||.|....:| .|.::|.|::||
Human  1216 IAEQQRRQEKIQAVLE--DHSQMRQMELEIRPLFLVPDTNGFIDHLASLARL-LESRKYILVVPL 1277

  Fly   805 TVVKELDGLSKGVKLDSYRSSKQTQRIHHFDEVSSRAKKSLEFI----KSAKGNVKCATTKGSFV 865
            .|:.|||||:||.:.| :|:....:      .|..:|:||:||:    :|....::..|::|:.:
Human  1278 IVINELDGLAKGQETD-HRAGGYAR------VVQEKARKSIEFLEQRFESRDSCLRALTSRGNEL 1335

  Fly   866 NASVFAL--VEEEYLSNDDKILATAMAVSKTAKTEQCTD-GKCFIQT----------ELVLITTD 917
            .:..|..  :..:..:|||.||:..:        ..|.| .|.|:..          |:||:|.|
Human  1336 ESIAFRSEDITGQLGNNDDLILSCCL--------HYCKDKAKDFMPASKEEPIRLLREVVLLTDD 1392

  Fly   918 RNLRVKALSRNLAVSALDEFLQWAK 942
            ||||||||:||:.|..:..||.||:
Human  1393 RNLRVKALTRNVPVRDIPAFLTWAQ 1417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Smg6NP_651321.1 EST1 219..298 CDD:463062 26/100 (26%)
EST1_DNA_bind 310..639 CDD:431239 100/370 (27%)
PIN_Smg6-like 767..941 CDD:350233 65/190 (34%)
SMG6NP_060045.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 25..79
EJC-binding motif 1, mediates interaction with the EJC 39..59
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 99..165
Interaction with telomeric DNA 114..503 32/161 (20%)
EJC-binding motif 2, mediates interaction with the EJC 133..153
PRK12678 147..>338 CDD:237171
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 177..405 15/63 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 419..472 12/52 (23%)
EST1 638..743 CDD:463062 28/104 (27%)
EST1_DNA_bind 751..1103 CDD:431239 98/366 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..883 9/36 (25%)
PIN_Smg6-like 1241..1416 CDD:350233 65/190 (34%)
Blue background indicates that the domain is not in the aligned region.

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