Protein Alignment Smg6 and Smg7

DIOPT Version :9

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: XP_006529513.1
• Gene: Smg7 / 226517
• MGIID: 2682334
• Length: 1192
• Species: Mus musculus
• Alignment Length: 709
• Identity: 146/709 - (20%)
• Similarity: 249/709 - (35%)
• Gaps: 203/709 - (28%)

  Fly   200 LQDAFKQLLLEQLKFVCEHKVDVFFWKLLFYNVRNYLKRQQTDQAH-------THTLLLIEQAIK 257
            |||.::::|:..|::..:.||:...|...|.|....|:.|..::|:       .:..|.:|.|..
Mouse    44 LQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASG 108

  Fly   258 FYRMLYDKLMA------KC-VASSRC-----------------DSALKVVAQRLLICLGDLTRYR 298
            ||..|..:|..      .| |.||:.                 .|:...:.|..|:.|||:.|||
Mouse   109 FYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHSSTIVKPQSSSCSYICQHCLVHLGDIARYR 173

  Fly   299 VNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSL-------LTSN 356
                  ....:|..||:.|.:|||.||.|:||||:::.........::||.||:       ..|.
Mouse   174 ------NQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAAST 232

  Fly   357 SIQSAKESLLDLFDEIRRKYEETEMKQSPMHYAAGSKNQKSKQMRKEVWIYPDGIRRLHRTDDKG 421
            ::|.|....|:..||::.|                             |...|
Mouse   233 NLQKALSKALESRDELKTK-----------------------------WGVSD------------ 256

  Fly   422 NKAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTDVDSLYPLLRKLQIQIGVALRH 486
                                       .:..::...|.:|....::.|.||..||:.|. ..|..
Mouse   257 ---------------------------FIKAFIKFHGHVYLSKSLEKLSPLREKLEEQF-KRLLF 293

  Fly   487 ENLLSRSKLLKIVALNLFVVEHNKPKTSRREMRYHSFN------------FANSFFGLMMKKTNQ 539
            :...:..:|:.:..:|||.:.|.:..::..|.  ||::            ...||.|::.|..
Mouse   294 QKAFNSQQLVHVTVINLFQLHHLRDFSNETEQ--HSYSQDEQLCWTQLLALFMSFLGILCKCP-- 354

  Fly   540 LLAGFVEDSTNVQCLPEEDFATVNTYLQFVNVYVRWLSISLDVWEPVRSEEHSFIDCWAELTILF 604
             |....::|.|...||.            |.|.:.||.:...|::....:|..:|..|
Mouse   355 -LQNDSQESNNAYPLPA------------VKVSMDWLRLRPRVFQEAVVDERQYIWPW------- 399

  Fly   605 EYIECLMGKHKLE-----KNEILLDEDVALRGFTPLGRETLSMDYL---------KRGSERLQFF 655
             .|..|...|..|     .|...|.|:..|:||..|.....::|:.         |.|.:|....
Mouse   400 -LISLLNSFHPREDDLSNTNATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQ 463

  Fly   656 ERVRRIGQF----QEYYVQHQEALQQPLESSFTVEHLNAAMKNALENYDAESCGLAANVSKIQCK 716
            :|:..||::    |...:|.:..:.:.|   |..|.....:::..|..:        |:...:..
Mouse   464 QRLISIGKWIADNQPRLIQCENEVGKLL---FITEIPELILEDPSEAKE--------NLILQETS 517

  Fly   717 AVEELLCRSTDSDVSELCKLKKELEAKARVKQICTSKLEDILKFVDTKIYIEVRPRYL-----LP 776
            .||.|   :||....    ||..|.........|.|..:.::.|.:     .::||.:     .|
Mouse   518 VVESL---ATDGSPG----LKSVLSTGRNPSNSCDSGEKPVVTFKE-----NIKPREVNQGRSFP 570

  Fly   777 DTNCFIDC-------LEDFEKLSTEFKRYTLIIPLTVVKELDGLSKGVKLDSYRSSKQT 828
            ......||       .||.:|.|::.:..|....|..::|....|..|::.|....::|
Mouse   571 PKEVRRDCSKGVTVTQEDGQKDSSKRRAETKRCTLGKLQETGKQSVAVQVKSQTELRKT 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	190..298	CDD:287360	31/128 (24%)
		EST1_DNA_bind	310..638	CDD:287359	72/351 (21%)
		P-loop_NTPase	<616..>769	CDD:304359	33/170 (19%)
		PIN_Smg6	767..941	CDD:189055	16/74 (22%)
Smg7	XP_006529513.1	EST1	63..175	CDD:371012	28/117 (24%)
		TPR repeat	162..188	CDD:276809	11/31 (35%)
		EST1_DNA_bind	179..438	CDD:371011	72/352 (20%)
		TPR repeat	193..223	CDD:276809	11/29 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810