Protein Alignment Smg6 and smg-7

DIOPT Version :10

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_501033.1
• Gene: smg-7 / 177435
• WormBaseID: WBGene00004885
• Length: 458
• Species: Caenorhabditis elegans
• Alignment Length: 580
• Identity: 103/580 - (17%)
• Similarity: 203/580 - (35%)
• Gaps: 195/580 - (33%)

  Fly   200 LQDAFKQLLLEQLK------------------FVCE------HKVDVFFWKLLFYNVRNYLKRQQ 240
            :.|.::||.:|..|                  ||.:      .:.||.||..|...:....|..:
 Worm     1 MSDEWEQLTVELRKIPRGTEAAPQYLRHLMKMFVADFETAVSKRFDVKFWNKLKSMMDEITKAME 65

  Fly   241 TDQAHTHTLLLIEQAIKFYRMLY------------------------DKLMAKCVASSRCDSALK 281
            .|:...|.:..:  ||.|...|.                        |..:.:....|:.:|  :
 Worm    66 NDRLVNHNVQNL--AIGFLTDLSLLVHYHYEIPNYGNDISKQLTWTPDVFLNRKPIKSKKNS--R 126

  Fly   282 VVAQRLLICLGDLTRYRVNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVY 346
            |....:|:.:|||.||:.|:.||.:      ||:::..:.|.:||.:|||.:||....|..::||
 Worm   127 VFMAYVLLRMGDLMRYKENYPKAQE------YYEQSCRINPADGAVWNQLGLISSLGAKNLESVY 185

  Fly   347 YYVRSLLTSNSIQSAKESLLDLFDEIRRKYEETEMKQSPMHYAAGSKNQKSKQMRKEVWIYPDGI 411
            ::.|:|..:....:|...|.::|                       ||..::.:.:
 Worm   186 FHTRALHATMEFPTASGGLTNIF-----------------------KNFANRDISR--------- 218

  Fly   412 RRLHRTDDKGNKAKGNKATMAEVNRYEEMPPEEILPRIVSLYLYLLGKLYTGTDVDSLYPLLRKL 476
                                       .||       |..|||..||:::...:::.....|:|
 Worm   219 ---------------------------PMP-------IKDLYLSCLGRIHFLLEIEDSSVHLQK- 248

  Fly   477 QIQIGVALRHENLLSRSKLLKIVALNLFVVEHNKPKTSRREMRYHSFNFANSFFGLMMKKTNQLL 541
               ||    .|...|:..::.:::    |.:|.:..|   |:...:..:..:.:....:...:.|
 Worm   249 ---IG----EEAATSKEMIVPLMS----VYKHLEDGT---ELEQRAVEYVKTIWCTAYRSLLKTL 299

  Fly   542 AGFVEDSTNVQCLPEEDFATVNTYLQFVNVYVRWLSISLDVWEPVRSEEHSFIDCWAELTILFEY 606
            ..:.|:|..:..:|.               .:..|::.|...:.:|..|....|   |:|.:.|:
 Worm   300 DDYKEESKKLADVPH---------------LLHILALLLCAPKLLRGIEDQTED---EVTSICEW 346

  Fly   607 IECLMGKHKLEKNEILLDEDVALRGFTPLGRETLSMDYLKRGSERLQFFERVRRIGQFQEYYVQH 671
            :.|.....|:                              :.|:...:|..::||    :|.:..
 Worm   347 LLCANCDEKI------------------------------KDSDAFGYFHCLQRI----QYPLTR 377

  Fly   672 QEALQQPLESSFTVEHLNAAMKNALENYDAESCGLAANVSKIQCKAVE-ELLCRSTDSDV 730
            .:..|:.:|.....|..::. ::.:...|.:|  |:.:.|:||.:..| |....|:|.:|
 Worm   378 TQLAQKLVEIEDEDESKDSD-QSTIPEEDQKS--LSTDTSRIQNEDSEPESESESSDEEV 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	219..298	CDD:463062	21/102 (21%)
		EST1_DNA_bind	310..639	CDD:431239	52/328 (16%)
		PIN_Smg6-like	767..941	CDD:350233
smg-7	NP_501033.1	TPR_2	130..161	CDD:429619	11/36 (31%)
		TPR repeat	130..158	CDD:276809	11/33 (33%)
		EST1_DNA_bind	149..>271	CDD:431239	37/205 (18%)