Protein Alignment Smg6 and smg-6

DIOPT Version :10

• Sequence 1: NP_651321.1
• Gene: Smg6 / 42994
• FlyBaseID: FBgn0039260
• Length: 948
• Species: Drosophila melanogaster
• Sequence 2: NP_497566.3
• Gene: smg-6 / 175367
• WormBaseID: WBGene00004884
• Length: 1241
• Species: Caenorhabditis elegans
• Alignment Length: 994
• Identity: 216/994 - (21%)
• Similarity: 352/994 - (35%)
• Gaps: 296/994 - (29%)

  Fly    79 DAQSKQPVLD---TSGKMAWEGGIPGILRVTTSVAGDVNRNGQGQGKNKSGNSARRRGRKDKEHA 140
            ||......|:   :||::|  |.|..:.|.........|||  .|...:...:.::|.:...|.|
 Worm   408 DASEYHGTLENHMSSGRLA--GRIQIVQRSQNGTEAGGNRN--RQSSEEKPRTYQKRSQNQSEMA 468

  Fly   141 TQSPVTRTRLTTEHPDWFEPLLGLPHAKNIVHLYDQLMVLN---------------QRNLILINW 190
            .::.:.|.|  .|..|..|       .|.|..:.:::..|:               :.::.|.|.
 Worm   469 NRAEINRRR--QEDIDRNE-------GKQIREISEKIEKLSAPVKKRDLKSAEKMAEISMELANI 524

  Fly   191 KNFCYIHDQLQD---AFKQLLLEQLKFVC--------------EHKVDVFFWKLLFYNVRNYLKR 238
            .:...|||.:..   ..:|.|..|..:.|              ...:.....|||...:..|...
 Worm   525 YSQVIIHDVIYSFTAGLEQKLFRQAFYKCIESLRTGSNSAAPDARLIRAVTQKLLLNGIVYYENL 589

  Fly   239 QQTDQAHTHTLL---------------LIEQAIKFYRMLYDKLMAKCVASSRCDSALKVVA---- 284
            ..|.:...|..|               |.||.|:.           .:...:.|||.:..|
 Worm   590 IATYETQFHVALTDALTWQSGSPSDEELCEQYIEL-----------PIGIQKFDSATQKTAIKSL 643

  Fly   285 QRLLICLGDLTRYRVNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIY------------ 337
            .|.||.||||.||:.....:.:|..:...||::.:|.|..|.|:|||.::..|
 Worm   644 SRHLISLGDLHRYKSLIDGSENYEISKSCYQKSSQLWPSTGHPYNQLGIVVYYSMLYRSARRARL 708

  Fly   338 ---------HHKR-FDAVYYYVRSLLTSNSIQSAKESLLDLFDEIR---RKYEETEMKQSPMHYA 389
                     ..|| .|..:...|:|..|:..:.||:.|....|.:|   .||:....|:|.:...
 Worm   709 VPVDVLSRQRQKRVIDEFFCLTRALACSHPYEVAKDRLKQRIDAMRTKVAKYQPVLDKESGIVKE 773

  Fly   390 AGSKNQKSKQMRKEVWIYPDGIRRLHRTDDKGNKAKGNKATMAEVNRYEEMPPEEILPRIVSLYL 454
            .|:..::.:::| ::||:|     :..|...|.   |.:.....:..:.|....::..|.||...
 Worm   774 QGNVLRRLQRIR-QIWIHP-----ITETSQDGT---GERIVDDVLVHFMEHSKAKLHRRAVSYLC 829

  Fly   455 YLLGKLYTGTDVDS-----------LYPLLRKLQIQIGVALRHENLLSRSKLLKIVALNLFVVEH 508
            ...|.|.|...:|.           ||..|.|          .|...|..:|:|..|:.::..:.
 Worm   830 DTFGMLVTKIGMDHFESVSERAFGLLYASLSK----------SETDFSADQLVKFSAMFIYAAQV 884

  Fly   509 N----KPKTSRREMRYHSFNFANSFFGLMMKKTNQLLAGFVEDSTNVQCLPEEDFATVNTYLQFV 569
            |    .|.||:.:: :.:.....::|.::::..          ||:...|           |...
 Worm   885 NFDKSTPSTSKSQL-HTAVRTIFTYFLVLLEHI----------STHTTLL-----------LPAA 927

  Fly   570 NVYVRWLSISLDVWEPVRSEEHSFIDCWAELTILFEYIECLMGKHKLEKNEILLDEDVALRGFTP 634
            ||...|                                              :|..|.
 Worm   928 NVIATW----------------------------------------------ILHADT------- 939

  Fly   635 LGRETLSMDYLKRGSERLQFFERVRRIGQFQEYYVQHQEALQQPLESSFT--VEHLNAAMKNALE 697
              .|.||                          |::|.|.|...:.|||:  ..:|.:..:|. |
 Worm   940 --EELLS--------------------------YLEHLEPLSSTIISSFSNFPPNLESEAENP-E 975

  Fly   698 NYDAESCGLAANVSKIQCKAVEELLC-RSTD-SDVSELCKL-----KKELEAKARVKQICTSKLE 755
            |.......|.|:..||.......:.| |||: |...|..|:     :|..::....||    ||.
 Worm   976 NVTTPEAILLASFFKIYEPNPTPVRCSRSTNISQAVEKLKILGFSAEKSEKSGENGKQ----KLG 1036

  Fly   756 DIL-------KFVDT-----KIYIEVRPRYLLPDTNCFIDCLEDFEKL---STEFKRYTLIIPLT 805
            |.|       :.:|.     |..|.:.|.||:||||..|..|:..:.|   :.:.|::.:::|.|
 Worm  1037 DGLEEPKSREQMIDEQRGLGKTTIVIHPEYLIPDTNVLIGDLQLMKNLLETAQKNKKFQILVPTT 1101

  Fly   806 VVKELDGLSKGVKLDSYRSSKQTQRIHHFDEVSSRAKKSLEFIK-SAK---GNVKCATTKGSFVN 866
            |:.||..::|...|||..:|:.     |..|..|:||.::.::| .||   |::...||.|.  .
 Worm  1102 VLDELQYIAKLSPLDSKSNSEA-----HDPERISKAKIAVAWLKEQAKQKTGHLYTLTTTGK--R 1159

  Fly   867 ASVFALVEE-----EYLSNDDKILATAMAVSK-----TAKTEQCTDGKCFIQTELVLITTDRNLR 921
            ....::|.|     |..:|||.||.:|:..|:     ||.:......||      ||||.||.|.
 Worm  1160 LPTLSIVSEDLEGHEMTTNDDMILNSALRWSESLPGSTAPSATEISQKC------VLITGDRGLT 1218

  Fly   922 VKALSRNLAVSALDEFLQW 940
            :||:..|.....:..|.:|
 Worm  1219 IKAIGNNFPCRGISNFTKW 1237

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Smg6	NP_651321.1	EST1	219..298	CDD:463062	23/97 (24%)
		EST1_DNA_bind	310..639	CDD:431239	64/368 (17%)
		PIN_Smg6-like	767..941	CDD:350233	60/191 (31%)
smg-6	NP_497566.3	EST1	540..661	CDD:463062	28/131 (21%)
		EST1_DNA_bind	669..995	CDD:431239	82/448 (18%)
		PIN_Smg6-like	1060..1237	CDD:350233	59/189 (31%)