Protein Alignment Hr96 and NR1I2

DIOPT Version :10

• Sequence 1: NP_524493.1
• Gene: Hr96 / 42993
• FlyBaseID: FBgn0015240
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_071285.1
• Gene: NR1I2 / 8856
• HGNCID: 7968
• Length: 473
• Species: Homo sapiens
• Alignment Length: 731
• Identity: 140/731 - (19%)
• Similarity: 213/731 - (29%)
• Gaps: 351/731 - (48%)

  Fly     4 PKNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQN-CDITVVTRRFCQKCRLRKC 67
            |:.|.||||||.||:||.:|||.||.||||......:..|||.:. |:||..|||.||.||||||
Human    77 PQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKC 141

  Fly    68 LDIGMKSENIMSEE-----DKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSN 127
            |:.|||.|.|||:|     ..||||:|
Human   142 LESGMKKEMIMSDEAVEERRALIKRKK-------------------------------------- 168

  Fly   128 LDHYSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMR 192
                     |:..|:...|..|.:..|                             ...|..||.
Human   169 ---------SERTGTQPLGVQGLTEEQ-----------------------------RMMIRELMD 195

  Fly   193 TQKEAISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEII 257
            .|.:...                                         |.|:.|.:....||
Human   196 AQMKTFD-----------------------------------------TTFSHFKNFRLPGV--- 216

  Fly   258 SKIVDSPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLD 322
               :.|..::.|.:|                  .|:.             ..||:.:..||.|..
Human   217 ---LSSGCELPESLQ------------------APSR-------------EEAAKWSQVRKDLCS 247

  Fly   323 KEPAVKPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDF 387
            .:                                |.||..    ||..|.
Human   248 LK--------------------------------VSLQLR----GEDGSV--------------- 261

  Fly   388 DLKTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGC 452
                     :|.:|..||  ....|.|:|
Human   262 ---------WNYKPPADS--GGKEIFSLL------------------------------------ 279

  Fly   453 NSAANNSQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKP 517
                    ||:                                       .|:|..|
Human   280 --------PHM---------------------------------------ADMSTYM-------- 289

  Fly   518 DDTRHNPKLLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDR 582
                               .|.:|..||.|:.|||:..|||::||||...|:..:|...:::.:.
Human   290 -------------------FKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAET 335

  Fly   583 AAWKVPH----TKENMGNIRTDLLKFAEGNIYEEHQKFITTFDEKWRMDENIILIMCAIVLFTSA 643
            ..|:...    .::..|..:..||        |...||.... :|.::.|...::|.||.||:..
Human   336 GTWECGRLSYCLEDTAGGFQQLLL--------EPMLKFHYML-KKLQLHEEEYVLMQAISLFSPD 391

  Fly   644 RSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDVERLN----KFIINVYLN 704
            |..|:...|:...|..:...|:.|:|........|..|:|::..::::..:|    :.::.:. :
Human   392 RPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQ-D 455

  Fly   705 VNPSQVEPLLREIFDL 720
            ::|. ..||::|:|.:
Human   456 IHPF-ATPLMQELFGI 470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	51/98 (52%)
		NR_LBD	462..>573	CDD:472173	20/110 (18%)
		NR_LBD_F1	523..702	CDD:132727	42/186 (23%)
NR1I2	NP_071285.1	NR_DBD_PXR	79..166	CDD:143536	48/86 (56%)
		NR_LBD_PXR_like	182..467	CDD:132732	82/574 (14%)