DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr96 and NR1H2

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_009052.4	Gene:	NR1H2 / 7376	HGNCID:	7965	Length:	460	Species:	Homo sapiens

Alignment Length:	330	Identity:	79/330 - (23%)
Similarity:	143/330 - (43%)	Gaps:	88/330 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNAL--AKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLD 69
            |.||||||.|:::|.::||.||.||||:.:  ..:::.|.....|.:....||.||:||||||.:
Human    87 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKE 151

  Fly    70 IGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSGS 134
            .||:.:.::|||.  |:::||...:.:.:             .:.:....|..|||      |.|
Human   152 AGMREQCVLSEEQ--IRKKKIRKQQQESQ-------------SQSQSPVGPQGSSS------SAS 195

  Fly   135 QDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEAIS 199
            ....|.|.:::|:.| ||   ...|.|:...|   |.::.|:|     |:|     ::..|.:.|
Human   196 GPGASPGGSEAGSQG-SG---EGEGVQLTAAQ---ELMIQQLV-----AAQ-----LQCNKRSFS 243

  Fly   200 VMEKVI-------SSQKDA----------LRLVS--HLIDY----PG-------DALKIISKFMN 234
            ...||.       ...:||          |.::|  .::|:    ||       |.:.::
Human   244 DQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALL----- 303

  Fly   235 SPFNALTVFTKFMSSPTDGVEIISKIVDSPADVVEFMQNLMHSPED--AIDIMNKFMNTPAEALR 297
               .|.|:....:.:        ::..:...:.:.|:::..:|.:|  ...:..:|:|...|..|
Human   304 ---KASTIEIMLLET--------ARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSR 357

  Fly   298 ILNRI 302
            .:.|:
Human   358 AMRRL 362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	37/92 (40%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
NR1H2	NP_009052.4	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000269\|PubMed:25661920	1..85
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		FAP	4..>71	CDD:311241
		NR_DBD_LXR	67..169	CDD:143534	35/83 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	169..216		14/69 (20%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000269\|PubMed:25661920	219..460		28/173 (16%)
		NR_LBD_LXR	223..458	CDD:132752	28/169 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157549
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940