Protein Alignment Hr96 and RORB

DIOPT Version :9

• Sequence 1: NP_524493.1
• Gene: Hr96 / 42993
• FlyBaseID: FBgn0015240
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_001351952.1
• Gene: RORB / 6096
• HGNCID: 10259
• Length: 470
• Species: Homo sapiens
• Alignment Length: 738
• Identity: 132/738 - (17%)
• Similarity: 227/738 - (30%)
• Gaps: 321/738 - (43%)

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLDIG 71
            |.:||||:.|.::..:|||.||.||||:......::||..:||.|....|..||.|||:|||.:|
Human    21 CKICGDKSSGIHYGVITCEGCKGFFRRSQQNNASYSCPRQRNCLIDRTNRNRCQHCRLQKCLALG 85

  Fly    72 MKSENIMSEEDKLIKRRK----IETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYS 132
            |..:.:  :..::.|:::    .|..:.::||.            |:|..:             |
Human    86 MSRDAV--KFGRMSKKQRDSLYAEVQKHQQRLQ------------EQRQQQ-------------S 123

  Fly   133 GSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEA 197
            |..::.:...:.|.:||.|.....:.||..|
Human   124 GEAEALARVYSSSISNGLSNLNNETSGTYAN---------------------------------- 154

  Fly   198 ISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVD 262
                              .|:||.|
Human   155 ------------------GHVIDLP---------------------------------------- 161

  Fly   263 SPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAV 327
                                                    .|.|..|.
Human   162 ----------------------------------------KSEGYYNV----------------- 169

  Fly   328 KPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFDLKTF 392
                              :|...||..:.:|:    .|:.:            |...|.:||.:.
Human   170 ------------------DSGQPSPDQSGLDM----TGIKQ------------IKQEPIYDLTSV 200

  Fly   393 MQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCNSAAN 457
                    |:|                  ..|.:||:.|.|......|:.          ..|.|
Human   201 --------PNL------------------FTYSSFNNGQLAPGITMTEID----------RIAQN 229

  Fly   458 NSQPHLQQPICAPSTQQLDR---ELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKPDD 519
            ..:.||:  .|..:.::|.:   :.:..|::|..:.: :.|||:...
Human   230 IIKSHLE--TCQYTMEELHQLAWQTHTYEEIKAYQSK-SREALWQQC------------------ 273

  Fly   520 TRHNPKLLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDRAA 584
                     .|.:|. ||:.:::.||:||.|.::||.||:.|||.||.|::::|....:
Human   274 ---------AIQITH-AIQYVVEFAKRITGFMELCQNDQILLLKSGCLEVVLVRMCRAF------ 322

  Fly   585 WKVPHTKENMGNIRTDLLKFAEGNIYEEHQKFIT---------TFDE-----KWRMDENIILIMC 635
                       |...:.:.| ||. |...|.|..         .||.     ..::.|..|.:..
Human   323 -----------NPLNNTVLF-EGK-YGGMQMFKALGSDDLVNEAFDFAKNLCSLQLTEEEIALFS 374

  Fly   636 AIVLFTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDVERLNKFIIN 700
            :.||.:..|:.:|....::..|...|:.|:..::..:...|.....|..|..|:.|..|:...:.
Human   375 SAVLISPDRAWLIEPRKVQKLQEKIYFALQHVIQKNHLDDETLAKLIAKIPTITAVCNLHGEKLQ 439

  Fly   701 VYLNVNPSQVE----PLLREIFD 719
            |:...:|..|.    ||.:|:|:
Human   440 VFKQSHPEIVNTLFPPLYKELFN 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	33/94 (35%)
		NR_LBD	462..>573	CDD:299703	28/113 (25%)
		NR_LBD_F1	523..702	CDD:132727	44/192 (23%)
RORB	NP_001351952.1	NR_DBD_ROR	14..108	CDD:143526	32/88 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	104..127		7/47 (15%)
		NR_LBD_ROR_like	221..461	CDD:132737	62/299 (21%)
		AF-2	456..461		2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157569
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7184
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.790