DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr96 and RORA

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_599022.1	Gene:	RORA / 6095	HGNCID:	10258	Length:	556	Species:	Homo sapiens

Alignment Length:	737	Identity:	137/737 - (18%)
Similarity:	228/737 - (30%)	Gaps:	323/737 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLDIG 71
            |.:||||:.|.::..:|||.||.||||:..:...::||..:||.|...:|..||.|||:|||.:|
Human   106 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVG 170

  Fly    72 MKSENI----MSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYS 132
            |..:.:    ||::    :|..:.....|.|:.:           ::|||:
Human   171 MSRDAVKFGRMSKK----QRDSLYAEVQKHRMQQ-----------QQRDHQ-------------- 206

  Fly   133 GSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEA 197
                                   ..|| :..||..|
Human   207 -----------------------QQPG-EAEPLTPT----------------------------- 218

  Fly   198 ISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVD 262
                                               .|...|.||.....:|:..||
Human   219 -----------------------------------YNISANGLTELHDDLSNYIDG--------- 239

  Fly   263 SPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAV 327
                         |:||
Human   240 -------------HTPE------------------------------------------------ 243

  Fly   328 KPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQP---STSSSHPLPYIANSPDFDL 389
                 ..:||:.:.|...:..| ||..:.:|:.    |:..:|   .|.:|...||.:
Human   244 -----GSKADSAVSSFYLDIQP-SPDQSGLDIN----GIKPEPICDYTPASGFFPYCS------- 291

  Fly   390 KTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCNS 454
                .||....|::.           ::|:..:......|..:....::||:...|..|:
Human   292 ----FTNGETSPTVS-----------MAELEHLAQNISKSHLETCQYLREELQQITWQTF----- 336

  Fly   455 AANNSQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKPDD 519
                    ||:.|             |..|.|.||:
Human   337 --------LQEEI-------------ENYQNKQREV----------------------------- 351

  Fly   520 TRHNPKLLQL--INLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDR 582
                  :.||  |.:|. ||:.:::.||:|..|.::||.||:.|||.|..|::.:|....:|...
Human   352 ------MWQLCAIKITE-AIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFIRMCRAFDSQN 409

  Fly   583 AAWKVPHTKENMGNIRTDLLKFAEGNIY-----EEHQKFITTFDE---KWRMDENIILIMCAIVL 639
                  :|....|       |:|..:::     |:...|:..|.:   ...:.|:.|.:..|.||
Human   410 ------NTVYFDG-------KYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEIALFSAFVL 461

  Fly   640 FTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDV--------ERLNK 696
            .::.||.:..|..|...|......|:..|:..:   .......|||.|:|.:        |:|..
Human   462 MSADRSWLQEKVKIEKLQQKIQLALQHVLQKNH---REDGILTKLICKVSTLRALCGRHTEKLMA 523

  Fly   697 FIINVYLNVNPSQVEPLLREIF 718
            |.. :|.::......||.:|:|
Human   524 FKA-IYPDIVRLHFPPLYKELF 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	35/94 (37%)
		NR_LBD	462..>573	CDD:299703	27/112 (24%)
		NR_LBD_F1	523..702	CDD:132727	48/196 (24%)
RORA	NP_599022.1	NR_DBD_ROR	99..193	CDD:143526	34/90 (38%)
RORA	NP_599022.1	NR_LBD_ROR_like	305..544	CDD:132737	66/317 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157574
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840