DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr96 and RARB

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_001277145.1	Gene:	RARB / 5915	HGNCID:	9865	Length:	455	Species:	Homo sapiens

Alignment Length:	425	Identity:	106/425 - (24%)
Similarity:	173/425 - (40%)	Gaps:	91/425 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSPP---KNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKC 62
            :.||   |.|.||.||:.||::....||.||.||||:......:||..::||.|..|||..||.|
Human    79 LPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYC 143

  Fly    63 RLRKCLDIGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADS--SS 125
            ||:||.::||..|::.::.:|    :|.||  :|:...|:.....:.|...|:..||..::  |.
Human   144 RLQKCFEVGMSKESVRNDRNK----KKKET--SKQECTESYEMTAELDDLTEKIRKAHQETFPSL 202

  Fly   126 SNLDHYSGSQDSQSCGSADSG--------ANGCSGR----QASSPGTQVNPLQMTAEKIVDQIVS 178
            ..|..|:.:..:......|.|        |..|..:    ....||       .|...|.|||.
Human   203 CQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPG-------FTGLTIADQIT- 259

  Fly   179 DPDRASQAINRLMRTQKEAISVME--KVISSQKDALRLVSHLIDYPGDALKI-ISKFMNSPFNAL 240
                       |::.....|.::.  ...:.::|.:..        .|.|.: .::..|:.|..|
Human   260 -----------LLKAACLDILILRICTRYTPEQDTMTF--------SDGLTLNRTQMHNAGFGPL 305

  Fly   241 T--VFT---KFMSSPTDGVE--IISKI---------VDSPADVVEFMQNLMHSPEDAIDIMNKFM 289
            |  |||   :.:....|..|  ::|.|         ::.|..|.:..:.|:.:.:  |.|..:..
Human   306 TDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALK--IYIRKRRP 368

  Fly   290 NTPAEALRILNRILSGGGANAAQQTADRKPLLDKE-PAVKPAAPAERADTVIQSMLGNS---PPI 350
            :.|....:||.:|......:|  :.|:|...|..| |...|        .:||.||.||   .|:
Human   369 SKPHMFPKILMKITDLRSISA--KGAERVITLKMEIPGSMP--------PLIQEMLENSEGHEPL 423

  Fly   351 SPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSP 385
            :|..:. :...|||.:......:|.     ::.||
Human   424 TPSSSG-NTAEHSPSISPSSVENSG-----VSQSP 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	39/92 (42%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
RARB	NP_001277145.1	Modulating	1..87		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..78
		NR_DBD_RAR	82..166	CDD:143522	36/87 (41%)
		Hinge	154..182		7/33 (21%)
		NR_LBD_RAR	186..416	CDD:132735	53/268 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..455		10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840