DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr96 and Nr1h3

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_113815.2	Gene:	Nr1h3 / 58852	RGDID:	61909	Length:	445	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	88/385 - (22%)
Similarity:	154/385 - (40%)	Gaps:	119/385 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLDIG 71
            |:||||||.|:::|.::||.||.||||:.:...::.|....:|.:....||.||:||||||...|
  Rat    96 CSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGARYICHSGGHCPMDTYMRRKCQECRLRKCRQAG 160

  Fly    72 MKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSGSQD 136
            |:.|.::|||...:|:.|                       .:.:.:|.|.|.|.
  Rat   161 MREECVLSEEQIRLKKLK-----------------------RQEEEQAQATSVSP---------- 192

  Fly   137 SQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKI--VDQIVSDPDRASQAINRLMRTQKEAIS 199
                             :.||| .||.| |::.|::  ::::|:    |.|..||  |:..:.:.
  Rat   193 -----------------RVSSP-PQVLP-QLSPEQLGMIEKLVA----AQQQCNR--RSFSDRLR 232

  Fly   200 VMEKVISSQKD---------------ALRLVSHLIDY----PGDALKIISKFMNSPFNALTVFTK 245
            |....|:....               |:..|..::|:    ||             |..|:...:
  Rat   233 VTPWPIAPDPQSREARQQRFAHFTELAIVSVQEIVDFAKQLPG-------------FLQLSREDQ 284

  Fly   246 FMSSPTDGVEII----SKIVDSPADVVEFMQNLMHSPED--AIDIMNKFMNTPAEALRILNRILS 304
            .....|..:|::    |:..:..::.:.|:::..::.||  ...:..:|:|...|..|.:|.:
  Rat   285 IALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRSMNEL-- 347

  Fly   305 GGGANAAQ---------QTADRKPLLDKEPAVKPAAPAERAD-TVIQSMLGNSPPISPHD 354
              ..|.|:         .:|||       |.|:.....||.. |.::::........|||
  Rat   348 --QLNDAEFALLIAISIFSADR-------PNVQDQLQVERLQHTYVEALHAYVSINHPHD 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	37/90 (41%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
Nr1h3	NP_113815.2	Transactivation AF-1, required for ligand-independent transactivation function. /evidence=ECO:0000250\|UniProtKB:Q13133	1..94
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..86
		NR_DBD_LXR	76..176	CDD:143534	35/79 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..200		8/72 (11%)
		Transactivation AF-2, required for ligand-dependent transactivation function, mediates interaction with CCAR2. /evidence=ECO:0000250\|UniProtKB:Q13133	203..445		41/226 (18%)
		NR_LBD_LXR	208..443	CDD:132752	39/221 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351543
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.940