DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr96 and Nr1h2

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	XP_038944684.1	Gene:	Nr1h2 / 58851	RGDID:	61906	Length:	446	Species:	Rattus norvegicus

Alignment Length:	374	Identity:	85/374 - (22%)
Similarity:	150/374 - (40%)	Gaps:	130/374 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNAL--AKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLD 69
            |.||||||.|:::|.::||.||.||||:.:  ...::.|..:..|.:....||.||.||||||.:
  Rat    78 CRVCGDKASGFHYNVLSCEGCKGFFRRSVVHGGAGRYACRGSGTCQMDAFMRRKCQLCRLRKCKE 142

  Fly    70 IGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSGS 134
            .||:.:.::|||.  |:::||:                                          .
  Rat   143 AGMREQCVLSEEQ--IRKKKIQ------------------------------------------K 163

  Fly   135 QDSQSCGSADSGANGCSGRQASSPGT---------QVNPLQMTA--EKIVDQIVSDPDRASQAIN 188
            |..|........|:|.|.|.|:||||         :...:|:||  |.::.|:|     |:|
  Rat   164 QQQQQPPPPTEPASGSSARPAASPGTSEASSQGSGEGEGIQLTAAQELMIQQLV-----AAQ--- 220

  Fly   189 RLMRTQKEAISVMEKVI-------SSQKDA----------LRLVS--HLIDY----PG------- 223
              ::..|.:.|...||.       ...:||          |.::|  .::|:    ||
  Rat   221 --LQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGRE 283

  Fly   224 DALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVDSPADVVEFMQNLMHSPED--AIDIMN 286
            |.:.::        .|.|:....:.:        ::..:...:.:.|:::..:|.:|  ...:..
  Rat   284 DQIALL--------KASTIEIMLLET--------ARRYNHETECITFLKDFTYSKDDFHRAGLQV 332

  Fly   287 KFMNTPAEALRILNRILSGGGANAAQQ---------TADRKPLLDKEPA 326
            :|:|...|..|.:.|:    |.:.|:.         :|||..:  :||:
  Rat   333 EFINPIFEFSRAMRRL----GLDDAEYALLIAINIFSADRPNV--QEPS 375

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	37/92 (40%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
Nr1h2	XP_038944684.1	NR_DBD_like	58..154	CDD:413390	32/75 (43%)
Nr1h2	XP_038944684.1	NR_LBD_LXR	209..444	CDD:132752	34/199 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.030