DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr96 and nr1i2

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_001092087.2	Gene:	nr1i2 / 565875	ZFINID:	ZDB-GENE-030903-3	Length:	430	Species:	Danio rerio

Alignment Length:	722	Identity:	136/722 - (18%)
Similarity:	218/722 - (30%)	Gaps:	347/722 - (48%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PKNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCL 68
            ||.|.|||||:.||:|||:|||.||.||||......|..|||...|.||...||.||.|||:|||
Zfish    43 PKICQVCGDKSTGYHFNAMTCEGCKGFFRRAMKRPAQLCCPFQSACVITKSNRRQCQSCRLQKCL 107

  Fly    69 DIGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSG 133
            .||||.|.|||  |:.:::|:::..|  :|:.|
Zfish   108 SIGMKRELIMS--DEAVEKRRLQIRR--KRMQE-------------------------------- 136

  Fly   134 SQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEAI 198
                                         .|:.:|                        .|:||
Zfish   137 -----------------------------EPVTLT------------------------PQQEA- 147

  Fly   199 SVMEKVISSQKDALRLV-SHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVD 262
             |:::::::.|....:. :|                         |::|
Zfish   148 -VIQELLNAHKKTFDMTCAH-------------------------FSQF---------------- 170

  Fly   263 SPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAV 327

Zfish   171 ----------------------------------------------------------------- 170

  Fly   328 KPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFDLKTF 392
               .|.:|.    |..:..|.|:: :.:.:|   |.| :.|.       |:.::.||      |.
Zfish   171 ---RPLDRG----QKSVSESIPVT-NGSWID---HRP-IAED-------PVQWVFNS------TS 210

  Fly   393 MQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCNSAAN 457
            :.::.:...|||                                 ||:..:         .|.:.
Zfish   211 LSSSSSSCQSLD---------------------------------KEKKHF---------KSGSF 233

  Fly   458 NSQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKPDDTRH 522
            .|.||
Zfish   234 TSLPH------------------------------------------------------------ 238

  Fly   523 NPKLLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDRAAWKV 587
                  ..:||...||.:|...|.:|.||.:..|||::||||...|::::...|.:::....|:.
Zfish   239 ------FTDLTTYMIKNVINFGKTLTMFRALVMEDQISLLKGATFEIILIHFNMFFNEVTGIWEC 297

  Fly   588 PHTKENMGNIRTDLLKFAEGNIYEEH-----QKFITTFDEKWRMDENIILIMCAIVLFTSARSRV 647
            ...:..|.:      .|..|  ::.|     ..|..|. .|.|:.|...::|.|:.||:..|..|
Zfish   298 GPLQYCMDD------AFRAG--FQHHLLDPMMNFHYTL-RKLRLHEEEYVLMQALSLFSPDRPGV 353

  Fly   648 IHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDVERLNKFIINVYLNVNPSQ--V 710
            ....||...|.:....|:.|:|:..:|.|....|.|::..::::..:|:......|.:...|  |
Zfish   354 TDHKVIDRNQETLALTLKTYIEAKRNGPEKNLLFPKIMGCLTEMRSMNEEYTKQVLKIQDMQPEV 418

  Fly   711 EPLLREI 717
            .||..||
Zfish   419 SPLWLEI 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	49/92 (53%)
		NR_LBD	462..>573	CDD:299703	18/110 (16%)
		NR_LBD_F1	523..702	CDD:132727	45/183 (25%)
nr1i2	NP_001092087.2	NR_DBD_PXR	45..131	CDD:143536	47/87 (54%)
nr1i2	NP_001092087.2	NR_LBD_PXR_like	141..425	CDD:132732	81/557 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593361
Domainoid	1	1.000	103	1.000	Domainoid score	I6716
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40757
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4089
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153746at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X988
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.000