Protein Alignment Hr96 and roraa

DIOPT Version :10

• Sequence 1: NP_524493.1
• Gene: Hr96 / 42993
• FlyBaseID: FBgn0015240
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: XP_017209577.1
• Gene: roraa / 564951
• ZFINID: ZDB-GENE-060306-2
• Length: 519
• Species: Danio rerio
• Alignment Length: 739
• Identity: 133/739 - (17%)
• Similarity: 234/739 - (31%)
• Gaps: 327/739 - (44%)

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLDIG 71
            |.:||||:.|.::..:|||.||.||||:..:...::||..:||.|...:|..||.|||:|||.:|
Zfish    69 CKICGDKSSGIHYGVITCEGCKGFFRRSQQSNAAYSCPRQKNCLIDRTSRNRCQHCRLQKCLAVG 133

  Fly    72 MKSENI----MSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYS 132
            |..:.:    ||::    :|..:.....|.||.:           ::|||:
Zfish   134 MSRDAVKFGRMSKK----QRDSLYAEVQKHRLQQ-----------QQRDHQ-------------- 169

  Fly   133 GSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEA 197
                                   ..|| :..||
Zfish   170 -----------------------QQPG-EAEPL-------------------------------- 178

  Fly   198 ISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEI--ISKI 260
                                                               :||.|:..  ::::
Zfish   179 ---------------------------------------------------TPTYGLSTNGLTEL 192

  Fly   261 VDSPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEP 325
            .|   |:..:|..  |:|:
Zfish   193 HD---DLSGYMNG--HTPD---------------------------------------------- 206

  Fly   326 AVKPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQP---STSSSHPLPYIANSPDF 387
            ..||       |:.:.|...:..| ||..:.:|:.    |:..:|   .|..|...||.:
Zfish   207 GTKP-------DSGVSSFYLDIQP-SPDQSGLDIN----GIKPEPICDFTPGSGFFPYCS----- 254

  Fly   388 DLKTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGC 452
                  .||....|::.           ::|:..:......|..:....::||:.   |.|:
Zfish   255 ------FTNGETSPTVS-----------MAELEHLAQNISKSHMETCQYLREELQ---QMTW--- 296

  Fly   453 NSAANNSQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKP 517
                   |..||:.:             |..|.|.||:
Zfish   297 -------QAFLQEEV-------------ENYQSKPREV--------------------------- 314

  Fly   518 DDTRHNPKLLQL--INLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDD 580
                    :.||  |.:|. ||:.:::.||:|..|.::||.||:.|||.|..|::.:|....:|.
Zfish   315 --------MWQLCAIKITE-AIQYVVEFAKRIDGFMELCQNDQIVLLKAGSLEVVFVRMCRAFDP 370

  Fly   581 DR------AAWKVPHTKENMG--NIRTDLLKFAEGNIYEEHQKFITTFDEKWRMDENIILIMCAI 637
            ..      ..:..|...:::|  ::.:.:.:|.: |:...|            :.|:.|.:..|.
Zfish   371 QNNTVYFDGKYAGPDVFKSLGCDDLISSVFEFGK-NLCSMH------------LSEDEIALFSAF 422

  Fly   638 VLFTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDV--------ERL 694
            ||.::.||.:..|..:...|......|:..|:..:   .......|||.|:|.:        |:|
Zfish   423 VLMSADRSWLQEKVKVEKLQQKIQLALQHVLQKNH---REDGILTKLICKVSTLRALCSRHTEKL 484

  Fly   695 NKFIINVYLNVNPSQVEPLLREIF 718
            ..|.. :|.::..:...||.:|:|
Zfish   485 TAFKA-IYPDIVRAHFPPLYKELF 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	35/94 (37%)
		NR_LBD	462..>573	CDD:472173	26/112 (23%)
		NR_LBD_F1	523..702	CDD:132727	45/196 (23%)
roraa	XP_017209577.1	NR_DBD_ROR	62..156	CDD:143526	34/90 (38%)
		NR_LBD_ROR_like	268..507	CDD:132737	63/317 (20%)