DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr96 and vdrb

DIOPT Version :9

Sequence 1:NP_524493.1 Gene:Hr96 / 42993 FlyBaseID:FBgn0015240 Length:723 Species:Drosophila melanogaster
Sequence 2:NP_001153457.1 Gene:vdrb / 564511 ZFINID:ZDB-GENE-080403-10 Length:422 Species:Danio rerio


Alignment Length:747 Identity:157/747 - (21%)
Similarity:235/747 - (31%) Gaps:381/747 - (51%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PKNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCL 68
            |:.|.||||||.|::|||:|||.||.||||:...|..||||||.:|.||...||.||.|||::||
Zfish    20 PRICGVCGDKATGFHFNAMTCEGCKGFFRRSMKRKASFTCPFNGSCTITKDNRRHCQACRLKRCL 84

  Fly    69 DIGMKSENIMSEED-----KLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNL 128
            ||||..|.|:::|:     :||:|||                       :|..|           
Zfish    85 DIGMMKEFILTDEEVQRKKELIQRRK-----------------------DEEAH----------- 115

  Fly   129 DHYSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRT 193
                                    |:|..|.                 :||..|           
Zfish   116 ------------------------REAQKPR-----------------LSDEQR----------- 128

  Fly   194 QKEAISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIIS 258
                                                                         .||.
Zfish   129 -------------------------------------------------------------NIID 132

  Fly   259 KIVDSPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDK 323
            .:||                                               |..:|.|       
Zfish   133 TLVD-----------------------------------------------AHHKTYD------- 143

  Fly   324 EPAVKPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFD 388
                                          |:..|.....|.|.|.|.|.|              
Zfish   144 ------------------------------DSYSDFSRFRPPVREGPVTRS-------------- 164

  Fly   389 LKTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCN 453
                                                         |||.         ::....:
Zfish   165 ---------------------------------------------ASRA---------ASLHSLS 175

  Fly   454 SAANNSQPHLQQPICAPSTQQLDRELNEAE-QMKLRELRLASEALYDPVDEDLSALMMGDDRIKP 517
            .|:::|..|        |.:..||::|.:. .|..:|..|:|..  |..:||.|:|.|       
Zfish   176 DASSDSFSH--------SPESGDRKMNLSNLLMMYQEQGLSSSP--DSKEEDGSSLSM------- 223

  Fly   518 DDTRHNPKLLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDR 582
                    |..|.:|.:.:|:::|..||.|..||::..|||:||||....|::::||...:..:.
Zfish   224 --------LPHLADLVSYSIQKVIGFAKMIPGFRELTAEDQIALLKSSAIEVIMLRSNQSFSLED 280

  Fly   583 AAW---------------KVPHTKENMGNIRTDLLKFAEG----NIYEEHQKFITTFDEKWRMDE 628
            .:|               |..||.|    :...|:||..|    |::||               |
Zfish   281 MSWSCGGPEFKYCVNDVTKAGHTLE----LLEPLVKFQVGLKKLNLHEE---------------E 326

  Fly   629 NIILIMCAIVLFTSARSRVIHKDVIRLE--QNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDV 691
            :::|:  ||.|.:..|..|  :|.:|:|  |:....:|:.|:.:.:.|  .|..:.|:|||::|:
Zfish   327 HVLLM--AICLLSPDRPGV--QDHVRVEALQDKVSEVLQAYIRAHHPG--GRLLYAKMIQKLADL 385

  Fly   692 ERLNKFIINVY--LNVNPS---QVEPLLREIF 718
            ..||:.....|  |:..|.   |:.||:.|:|
Zfish   386 RSLNEEHSKQYRSLSFQPEHSMQLTPLVLEVF 417

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr96NP_524493.1 NR_DBD_CAR 5..98 CDD:143524 51/97 (53%)
NR_LBD 462..>573 CDD:299703 33/111 (30%)
NR_LBD_F1 523..702 CDD:132727 54/199 (27%)
vdrbNP_001153457.1 NR_DBD_VDR 15..121 CDD:143513 56/158 (35%)
Hinge 96..125 11/103 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 106..128 11/96 (11%)
NR_LBD 123..421 CDD:299703 100/569 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 145..190 14/120 (12%)
Vitamin D3 binding. /evidence=ECO:0000250 224..234 3/9 (33%)
Interaction with coactivator LXXLL motif. /evidence=ECO:0000250 243..261 9/17 (53%)
Vitamin D3 binding. /evidence=ECO:0000250 268..275 2/6 (33%)
9aaTAD. /evidence=ECO:0000250|UniProtKB:P11473 411..419 4/7 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170593327
Domainoid 1 1.000 103 1.000 Domainoid score I6716
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 171 1.000 Inparanoid score I4089
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D153746at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24082
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6384
SonicParanoid 1 1.000 - - X988
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
1010.030

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