Protein Alignment Hr96 and PPARA

DIOPT Version :10

• Sequence 1: NP_524493.1
• Gene: Hr96 / 42993
• FlyBaseID: FBgn0015240
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_005027.2
• Gene: PPARA / 5465
• HGNCID: 9232
• Length: 468
• Species: Homo sapiens
• Alignment Length: 317
• Identity: 72/317 - (22%)
• Similarity: 120/317 - (37%)
• Gaps: 88/317 - (27%)

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQKCRLRKCLDI 70
            |.:|||||.||::....||.||.||||....|..: .|  :::|.|....|..||.||..|||.:
Human   102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFHKCLSV 164

  Fly    71 GMKSENI------MSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADS------ 123
            ||....|      .||:.||           |..::   |...|.:..|..|.|:.|..
Human   165 GMSHNAIRFGRMPRSEKAKL-----------KAEIL---TCEHDIEDSETADLKSLAKRIYEAYL 215

  Fly   124 SSSNLDHYSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQ---MTAEKIVDQIVSDPDRASQ 185
            .:.|::.......             .||:.:::|...::.::   |..:.:|.::|::..:..:
Human   216 KNFNMNKVKARVI-------------LSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKE 267

  Fly   186 AINRLMRTQKEAISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSP 250
            |..|:..             ..|..::..|:.|.::    .|.|..|.|...|......|:
Human   268 AEVRIFH-------------CCQCTSVETVTELTEF----AKAIPGFANLDLNDQVTLLKY---- 311

  Fly   251 TDGV-----EIISKIVDSPADVV---------EFMQNLMHSP-----EDAIDIMNKF 288
              ||     .::|.:::....:|         ||:::| ..|     |...|...||
Human   312 --GVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSL-RKPFCDIMEPKFDFAMKF 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	36/97 (37%)
		NR_LBD	462..>573	CDD:472173
		NR_LBD_F1	523..702	CDD:132727
PPARA	NP_005027.2	NR_DBD_Ppar	101..184	CDD:143523	33/83 (40%)
		NR_LBD_PPAR	201..467	CDD:132730	33/202 (16%)
		Required for heterodimerization with RXRA	304..433		13/69 (19%)