DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr96 and Eip75B

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_001246821.1	Gene:	Eip75B / 39999	FlyBaseID:	FBgn0000568	Length:	1412	Species:	Drosophila melanogaster

Alignment Length:	725	Identity:	150/725 - (20%)
Similarity:	253/725 - (34%)	Gaps:	226/725 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQKCRLRKCLDI 70
            |.||||||.|:::...:||.||.||||:...|.|: .|..||.|.|..:.|..||.|||:||:.:
  Fly   458 CRVCGDKASGFHYGVHSCEGCKGFFRRSIQQKIQYRPCTKNQQCSILRINRNRCQYCRLKKCIAV 522

  Fly    71 GMKSENI------MSEEDKLIKRRKIET-NRAKRRLMENGTDACDADGGEE------RDHKAPAD 122
            ||..:.:      ..|:.:::...:..| ||.::|.:     |.:.|....      |.|....:
  Fly   523 GMSRDAVRFGRVPKREKARILAAMQQSTQNRGQQRAL-----ATELDDQPRLLAAVLRAHLETCE 582

  Fly   123 SSSSNLDHYSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDP------- 180
            .:...:.  :..|.::.|.|            .|.|.....||....|...:|..|..
  Fly   583 FTKEKVS--AMRQRARDCPS------------YSMPTLLACPLNPAPELQSEQEFSQRFAHVIRG 633

  Fly   181 --DRASQAINRLMRTQKEAISVMEKVISSQKDAL--RL-------VSHLIDYPGDALK------- 227
              |.|.......:.||.:..::::   :...|||  ||       ::.:|...|..::
  Fly   634 VIDFAGMIPGFQLLTQDDKFTLLK---AGLFDALFVRLICMFDSSINSIICLNGQVMRRDAIQNG 695

  Fly   228 IISKFM-NSPFNALTVFTKFMSSP--TD--------------------GVEIISK---------- 259
            ..::|: :|.||    |.:.|:|.  ||                    .:|:|.|
  Fly   696 ANARFLVDSTFN----FAERMNSMNLTDAEIGLFCAIVLITPDRPGLRNLELIEKMYSRLKGCLQ 756

  Fly   260 --IVDSPADVVEFMQNLMHSPEDA-------IDIMNKFMNTPAEALRILNRILSGGGANAAQQTA 315
              :..:..|..||:..|:.:..|.       .:.:..|.....|.||.....:..|..:..||
  Fly   757 YIVAQNRPDQPEFLAKLLETMPDLRTLSTLHTEKLVVFRTEHKELLRQQMWSMEDGNNSDGQQ-- 819

  Fly   316 DRKPLLDKEPAVKPAAPAERADT-VIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLP 379
                  :|.|:   .:.|:..|. ..:|.||:   :|..::| ||.|.||        |||.|..
  Fly   820 ------NKSPS---GSWADAMDVEAAKSPLGS---VSSTESA-DLDYGSP--------SSSQPQG 863

  Fly   380 YIANSPDFDLKTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYG 444
            ....||.           ..:||     ::.|...:|:..:           .....::...:.|
  Fly   864 VSLPSPP-----------QQQPS-----ALASSAPLLAATL-----------SGGCPLRNRANSG 901

  Fly   445 TQSTYGGCNSAANNSQPHLQQ------PICAPSTQQLDRE----LNEA----------------E 483
            :....|........|..||.|      ||.....||..::    ||.|                :
  Fly   902 SSGDSGAAEMDIVGSHAHLTQNGLTITPIVRHQQQQQQQQQIGILNNAHSRNLNGGHAMCQQQQQ 966

  Fly   484 QMKLRELRLASEALYDPVD-------------EDLSALMMG------------DDRIKPDD--TR 521
            ..:|.....|..|.|..:|             .:..|:..|            ||.:...|  ..
  Fly   967 HPQLHHHLTAGAARYRKLDSPTDSGIESGNEKNECKAVSSGGSSSCSSPRSSVDDALDCSDAAAN 1031

  Fly   522 HNPKLLQLINLTAVAIKRLIKMAKKITA--FRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDR-- 582
            || :::|...|:.|::.. ::..:..|:  .:....||...|.:       ::::..:||.:.
  Fly  1032 HN-QVVQHPQLSVVSVSP-VRSPQPSTSSHLKRQIVEDMPVLKR-------VLQAPPLYDTNSLM 1087

  Fly   583 -AAWKVPHTK 591
             .|:| ||.|
  Fly  1088 DEAYK-PHKK 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	37/98 (38%)
		NR_LBD	462..>573	CDD:299703	29/165 (18%)
		NR_LBD_F1	523..702	CDD:132727	15/74 (20%)
Eip75B	NP_001246821.1	NR_DBD_REV_ERB	453..541	CDD:143540	34/82 (41%)
Eip75B	NP_001246821.1	NR_LBD_REV_ERB	609..796	CDD:132738	34/193 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24082
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010