DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr96 and Nr1d2

DIOPT Version :9

Sequence 1:NP_524493.1 Gene:Hr96 / 42993 FlyBaseID:FBgn0015240 Length:723 Species:Drosophila melanogaster
Sequence 2:NP_035714.3 Gene:Nr1d2 / 353187 MGIID:2449205 Length:576 Species:Mus musculus


Alignment Length:730 Identity:137/730 - (18%)
Similarity:230/730 - (31%) Gaps:311/730 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQKCRLRKCLDI 70
            |.||||.|.|:::....||.||.||||:.....|: .|..|:||.|..:.|..||:||.:|||.:
Mouse   103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSV 167

  Fly    71 GMKSENIMSEEDKLIKRRK----IETNRAKRRLM--------ENGTDACDADGGEERDHKA-PAD 122
            ||..:.:  ...::.||.|    ||...|.:.:|        :|.|.|      |:.|..| ||.
Mouse   168 GMSRDAV--RFGRIPKREKQRMLIEMQSAMKTMMNTQFSGHLQNDTLA------EQHDQSALPAQ 224

  Fly   123 SSSSNLDHYSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAI 187
            .                                     |:.|.....::.:....||        
Mouse   225 E-------------------------------------QLRPKSQLEQENIKNTPSD-------- 244

  Fly   188 NRLMRTQKEAISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTD 252
                                                                   |.|       
Mouse   245 -------------------------------------------------------FAK------- 247

  Fly   253 GVEIISKIVDSPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRI--------LNRILSGGGAN 309
             .|:|..:..:..|.  |:.|..|. |::.:.|     .|....||        ||:...|.|  
Mouse   248 -EEVIGMVTRAHKDT--FLYNQEHR-ENSSESM-----PPQRGERIPRNMEQYNLNQDHRGSG-- 301

  Fly   310 AAQQTADRKPLLDKEPAVKPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSS 374
                                              :.|..|.|.....:..||....:...|   :
Mouse   302 ----------------------------------IHNHFPCSERQQHLSGQYKGRNIMHYP---N 329

  Fly   375 SHPLPYIANSPDFDLKTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNS--IQQAASRV 437
            .|.: .|||.                                      ....|:|  .|:...|:
Mouse   330 GHAV-CIANG--------------------------------------HCMNFSSAYTQRVCDRI 355

  Fly   438 KEEMSYGTQSTYGGCNSAANNS--------QPHLQQPICAPSTQQLDRELNEAEQMKLRELRLAS 494
                      ..|||:...|.:        :.||..|:                          |
Mouse   356 ----------PVGGCSQTENRNSYLCNTGGRMHLVCPM--------------------------S 384

  Fly   495 EALYDPVDEDLSALMMGDDRIKPDDTRHNPKLLQLINLT-AVAIKRLIKMAKKITAFRDMCQEDQ 558
            ::.|                :.|..:.|  ::.:..::: ..|:|.:::.||:|..|||:.|.||
Mouse   385 KSPY----------------VDPQKSGH--EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQ 431

  Fly   559 VALLKGGCTEMMIMRSVMIYD-DDRAAWKVPHTKENMGNIRT----DLLKFAEGNIYEEHQKFIT 618
            |.|||.|..|::::|...::| .:|....:...|.::.::.:    |||    .:::|       
Mouse   432 VNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLL----SSMFE------- 485

  Fly   619 TFDEK---WRMDENIILIMCAIVLFTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNA 680
             |.||   .::.:..:.:..|:||.::.||.:.:.:.:...|.:....||..:...:.. || :.
Mouse   486 -FSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPN-EA-SI 547

  Fly   681 FIKLIQKISDVERLN 695
            |.||:.|:.|:..||
Mouse   548 FTKLLLKLPDLRSLN 562

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr96NP_524493.1 NR_DBD_CAR 5..98 CDD:143524 37/95 (39%)
NR_LBD 462..>573 CDD:299703 24/111 (22%)
NR_LBD_F1 523..702 CDD:132727 45/182 (25%)
Nr1d2NP_035714.3 Modulating 1..99
Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269|PubMed:29533925 1..60
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 13..90
NR_DBD_REV_ERB 98..186 CDD:143540 34/84 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 215..246 8/130 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 263..282 5/24 (21%)
NR_LBD_REV_ERB 386..574 CDD:132738 48/209 (23%)
Interaction with ZNHIT1. /evidence=ECO:0000250 394..576 46/185 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847968
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.840

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