DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr96 and ppardb

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_571543.1	Gene:	ppardb / 30754	ZFINID:	ZDB-GENE-000112-47	Length:	517	Species:	Danio rerio

Alignment Length:	448	Identity:	99/448 - (22%)
Similarity:	159/448 - (35%)	Gaps:	112/448 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQKCRLRKCLDI 70
            |.:|||||.|:::....||.||.||||....|.:: .|  .:.|.:...:|..||.||.:|||.:
Zfish   152 CRICGDKASGFHYGVHACEGCKGFFRRTIRMKLEYERC--ERACKVQKKSRNKCQYCRFQKCLAL 214

  Fly    71 GMKSENIM------SEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLD 129
            ||..:.|.      :|:.||:         |.....||...:..||......|...|...:.|:
Zfish   215 GMSHDAIRYGRMPEAEKKKLV---------AGLLAGENPQSSSGADLKTLAKHVNTAYLRNLNM- 269

  Fly   130 HYSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQ 194
                  ..:...|..:|...|:.           |.          ::.|.|...||.|.|:..|
Zfish   270 ------TKKKARSILTGKTSCTA-----------PF----------VIHDMDSLWQAENGLVWNQ 307

  Fly   195 KEAISVMEKV-----ISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNAL------TVFTKFMS 248
            .....:.:::     ...|...:..|..|.::..:....:..|:|.....|      .:|....|
Zfish   308 LNGAPLNKEIGVHVFYRCQCTTVETVRELTEFAKNIPGFVDLFLNDQVTLLKYGVHEAIFAMLPS 372

  Fly   249 -SPTDGVEIISKIVDSPADVV--EFMQNLMHSP-----EDAIDIMNKF----MNTPAEALRILNR 301
             ...||:     :|.:....|  ||:::| ..|     |...:...||    ::....||.:...
Zfish   373 LMNKDGL-----LVANGKGFVTREFLRSL-RKPFSEIMEPKFEFAVKFNALELDDSDLALFVAAI 431

  Fly   302 ILSGGGANAAQQTADRKPLLDKEPAVKPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGV 366
            ||.|          ||..|::    ||.....:  |.::|:       :..|     ||.|.|
Zfish   432 ILCG----------DRPGLMN----VKQVEQIQ--DGILQA-------LDQH-----LQVHHP-- 466

  Fly   367 GEQPSTSSSHPLPYIANSPDFDLKTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEY 424
                  .|||..|.:.... .||:..:..|......:....|..|:..:|.|:.:..|
Zfish   467 ------DSSHLFPKLLQKM-ADLRQLVTENAQLVQMIKKTESETSLHPLLQEIYKDMY 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	33/97 (34%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
ppardb	NP_571543.1	NR_DBD_Ppar	151..234	CDD:143523	30/83 (36%)
ppardb	NP_571543.1	NR_LBD_PPAR	250..516	CDD:132730	63/336 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.890