Protein Alignment Hr96 and nr1d2b

DIOPT Version :10

• Sequence 1: NP_524493.1
• Gene: Hr96 / 42993
• FlyBaseID: FBgn0015240
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_571140.1
• Gene: nr1d2b / 30271
• ZFINID: ZDB-GENE-990415-244
• Length: 578
• Species: Danio rerio
• Alignment Length: 706
• Identity: 145/706 - (20%)
• Similarity: 255/706 - (36%)
• Gaps: 244/706 - (34%)

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQKCRLRKCLDI 70
            |.||||.|.|:::....||.||.||||:.....|: .|..|::|.|..:.|..||:||.:|||.:
Zfish    86 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNESCPIMRINRNRCQQCRFKKCLLV 150

  Fly    71 GMKSENIMSEEDKLIKRRK----IETNRAKRRLMENGTDACDADGGEERDHK-APADSSSSNLDH 130
            ||..:.:  ...::.||.|    :|...|...:|.|      :.|.:..::: :.||.:|.:
Zfish   151 GMSRDAV--RFGRIPKREKQRMLLEMQNAMNNMMNN------SHGNQSLNNQTSAADGTSED--- 204

  Fly   131 YSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQK 195
                      |:::...:|.|.|..||     :|....:|       |.||...|.   .|.|
Zfish   205 ----------GTSEDSTSGPSSRSPSS-----SPRSNRSE-------SSPDPELQI---AMDT-- 242

  Fly   196 EAISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDG--VEIIS 258
                      ||..|:                                    ||.||.  .|:|.
Zfish   243 ----------SSSSDS------------------------------------SSATDSGEEEVIG 261

  Fly   259 KIVDSPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDK 323
            .:..:..:.  ||.| ......|.:.:|.:.:...:...:||.      .|.....:::.|
Zfish   262 TVTRAHQET--FMYN-QEQGSMASEALNNYSHCTEKTQEVLNH------QNNVSSVSEQNP---- 313

  Fly   324 EPAVKPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFD 388
                             ||..|   |..|.|:           |:..||.||.|:.
Zfish   314 -----------------QSSCG---PQGPEDS-----------GQDYSTLSSCPVR--------- 338

  Fly   389 LKTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCN 453
                :..|.:..|||.:                :.::|.|..:..|:.     || ...|:...|
Zfish   339 ----LSNNSSRGPSLQT----------------LTFRAHNDHETHANG-----SY-IVPTFPRAN 377

  Fly   454 SAANNSQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKPD 518
                  :.||   :|..:|...                                       :.|.
Zfish   378 ------RMHL---VCPMNTSPY---------------------------------------VDPQ 394

  Fly   519 DTRHNPKLLQLINLT-AVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYD-DD 581
            .:.|:  :.:..::: ..|::.:::.||:|..|:|:.|.|||:|||.|..|::::|...::| .:
Zfish   395 KSGHS--IWEEFSMSFTPAVREVVEFAKRIPGFKDLSQHDQVSLLKAGTFEVLVVRFTSLFDVKE 457

  Fly   582 RAAWKVPHTKENMGNIRT----DLLKFAEGNIYEEHQKFITTFDEKWR---MDENIILIMCAIVL 639
            |....:...|.::..:|:    |||    .::::        |.||.:   :.|..:.:..|:||
Zfish   458 RKVTFLSGRKYSVDALRSLGAGDLL----NSMFD--------FTEKLQALNLSEEEMSLFTAVVL 510

  Fly   640 FTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDVERLN 695
            .::.||.:.:.:.:...|.:....||..:...:....|  .|.||:.|:.|:..||
Zfish   511 VSADRSGLENVNSVEALQETLIRALRSLITKNHPNEIA--IFTKLLLKLPDLRSLN 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	35/95 (37%)
		NR_LBD	462..>573	CDD:472173	21/111 (19%)
		NR_LBD_F1	523..702	CDD:132727	43/182 (24%)
nr1d2b	NP_571140.1	NR_DBD_REV_ERB	81..169	CDD:143540	33/84 (39%)
		NR_LBD_REV_ERB	388..576	CDD:132738	45/232 (19%)