DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr96 and Nr1d2

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_671743.2	Gene:	Nr1d2 / 259241	RGDID:	628828	Length:	578	Species:	Rattus norvegicus

Alignment Length:	725	Identity:	137/725 - (18%)
Similarity:	231/725 - (31%)	Gaps:	299/725 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQKCRLRKCLDI 70
            |.||||.|.|:::....||.||.||||:.....|: .|..|:||.|..:.|..||:||.:|||.:
  Rat   103 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQCRFKKCLSV 167

  Fly    71 GMKSENIMSEEDKLIKRRK----IETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHY 131
            ||..:.:  ...::.||.|    ||...|.:.:|..                           .:
  Rat   168 GMSRDAV--RFGRIPKREKQRMLIEMQSAMKTMMST---------------------------QF 203

  Fly   132 SGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKE 196
            .|...|.                     |...|.:.:.....:|:...|             |.|
  Rat   204 GGHLQSD---------------------TLAEPHEQSVPPAQEQLRPKP-------------QLE 234

  Fly   197 AISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIV 261
                .|.:.|:..            |.|..|                          .|:|..:.
  Rat   235 ----QENIKSTPP------------PSDFAK--------------------------EEVIGMVT 257

  Fly   262 DSPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRI--------LNRILSGGGANAAQQTADRK 318
            .:..|.  |:.|..|. |::.:.|     .|....||        ||....|||
  Rat   258 RAHKDT--FLYNQEHR-ENSSESM-----PPHRGERIPRNVEQYNLNHDHRGGG----------- 303

  Fly   319 PLLDKEPAVKPAAPAERADTVIQSMLGNSPPISPHDAAVDLQY------HSPGVGEQPSTSSSHP 377
                                     |.:..|.|.....:..||      |.|. |.....|:.|.
  Rat   304 -------------------------LHSHFPCSESQQHLSGQYKGRNMMHYPN-GHTVCISNGHC 342

  Fly   378 LPYIANSPDFDLKTFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMS 442
            :.:.:..|                                             |:...|:
  Rat   343 VNFSSAYP---------------------------------------------QRVCDRI----- 357

  Fly   443 YGTQSTYGGCN-SAANNS-------QPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYD 499
                 ..|||: :.:.||       :.||..|:                          |::.|
  Rat   358 -----PVGGCSQTESRNSYLCSTGGRMHLVCPM--------------------------SKSPY- 390

  Fly   500 PVDEDLSALMMGDDRIKPDDTRHNPKLLQLINLT-AVAIKRLIKMAKKITAFRDMCQEDQVALLK 563
                           :.|..:.|  ::.:..::: ..|:|.:::.||:|..|||:.|.|||.|||
  Rat   391 ---------------VDPQKSGH--EIWEEFSMSFTPAVKEVVEFAKRIPGFRDLSQHDQVNLLK 438

  Fly   564 GGCTEMMIMRSVMIYD-DDRAAWKVPHTKENMGNIRT----DLLKFAEGNIYEEHQKFITTFDEK 623
            .|..|::::|...::| .:|....:...|.::.::.:    |||    .:::|        |.||
  Rat   439 AGTFEVLMVRFASLFDAKERTVTFLSGKKYSVDDLHSMGAGDLL----SSMFE--------FSEK 491

  Fly   624 ---WRMDENIILIMCAIVLFTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLI 685
               .::.:..:.:..|:||.::.||.:.:.:.:...|.:....||..:...:.. || :.|.||:
  Rat   492 LNGLQLSDEEMSLFTAVVLVSADRSGIENVNSVEALQETLIRALRTLIMKNHPN-EA-SIFTKLL 554

  Fly   686 QKISDVERLN 695
            .|:.|:..||
  Rat   555 LKLPDLRSLN 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	37/95 (39%)
		NR_LBD	462..>573	CDD:299703	24/111 (22%)
		NR_LBD_F1	523..702	CDD:132727	45/182 (25%)
Nr1d2	NP_671743.2	Modulating	1..99
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000250\|UniProtKB:Q60674	1..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..89
		NR_DBD_REV_ERB	98..186	CDD:143540	34/84 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	214..247		8/61 (13%)
		NR_LBD_REV_ERB	388..576	CDD:132738	48/209 (23%)
		Interaction with ZNHIT1. /evidence=ECO:0000250	396..578		46/185 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351547
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840