DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr96 and Vdr

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_058754.2	Gene:	Vdr / 24873	RGDID:	3959	Length:	423	Species:	Rattus norvegicus

Alignment Length:	740	Identity:	141/740 - (19%)
Similarity:	215/740 - (29%)	Gaps:	367/740 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PKNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCL 68
            |:.|.||||:|.|::|||:|||.||.||||:...|..||||||.:|.||...||.||.|||::|:
  Rat    21 PRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTCPFNGDCRITKDNRRHCQACRLKRCV 85

  Fly    69 DIGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSG 133
            ||||..|.|:::|:...||..|
  Rat    86 DIGMMKEFILTDEEVQRKREMI------------------------------------------- 107

  Fly   134 SQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEAI 198
                                                                    :.|.::||:
  Rat   108 --------------------------------------------------------MKRKEEEAL 116

  Fly   199 SVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVDS 263
                      ||:||                                            .|:.:.
  Rat   117 ----------KDSLR--------------------------------------------PKLSEE 127

  Fly   264 PADVVEFMQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAVK 328
            ...::..:.:..|...|           |..|
  Rat   128 QQHIIAILLDAHHKTYD-----------PTYA--------------------------------- 148

  Fly   329 PAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFDLKTFM 393
                                         |.:...|.|....||.|..|.|.::
  Rat   149 -----------------------------DFRDFRPPVRVDGSTGSYSPRPTLS----------- 173

  Fly   394 QTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCNSAANN 458
                         ||.||..|
  Rat   174 -------------FSGNSSSS-------------------------------------------- 181

  Fly   459 SQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDP-VDEDLSALMMGDDRIKPDDTRH 522
                        |:......|:..|......|.|..|...|| |..|||.|.|
  Rat   182 ------------SSDLYTTSLDMMEPSGFSNLDLNGEDSDDPSVTLDLSPLSM------------ 222

  Fly   523 NPKLLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDRAAW-- 585
               |..|.:|.:.:|:::|..||.|..|||:..:||:.|||....|::::||...:..|..:|
  Rat   223 ---LPHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSWDC 284

  Fly   586 -------------KVPHTKENMGNIRTDLLKFAEG----NIYEEHQKFITTFDEKWRMDENIILI 633
                         |..||.|    :...|:||..|    |::||               |:::|:
  Rat   285 GSQDYKYDVTDVSKAGHTLE----LIEPLIKFQVGLKKLNLHEE---------------EHVLLM 330

  Fly   634 MCAIVLFTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDVERLNKFI 698
              ||.:.:..|..|....::...|:.....|:.|:...:....:...:.|:|||::|:..||:..
  Rat   331 --AICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQKLADLRSLNEEH 393

  Fly   699 INVYLNV-----NPSQVEPLLREIF 718
            ...|.::     |..::.||:.|:|
  Rat   394 SKQYRSLSFQPENSMKLTPLVLEVF 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	47/92 (51%)
		NR_LBD	462..>573	CDD:299703	31/111 (28%)
		NR_LBD_F1	523..702	CDD:132727	48/197 (24%)
Vdr	NP_058754.2	NR_DBD_VDR	16..122	CDD:143513	55/253 (22%)
		Hinge	90..126		14/188 (7%)
		NR_LBD_VDR	124..422	CDD:132731	85/484 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..180		9/44 (20%)
		Vitamin D3 binding	223..233		3/9 (33%)
		Interaction with coactivator LXXLL motif	242..260		8/17 (47%)
		Vitamin D3 binding	267..274		2/6 (33%)
		9aaTAD. /evidence=ECO:0000250\|UniProtKB:P11473	412..420		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351538
Domainoid	1	1.000	99	1.000	Domainoid score	I6896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I4004
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153746at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24082
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X988
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.000