DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr96 and Rarb

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_001276689.1	Gene:	Rarb / 218772	MGIID:	97857	Length:	482	Species:	Mus musculus

Alignment Length:	425	Identity:	105/425 - (24%)
Similarity:	171/425 - (40%)	Gaps:	91/425 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSPP---KNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKC 62
            :.||   |.|.||.||:.||::....||.||.||||:......:||..::||.|..|||..||.|
Mouse   106 LPPPRVYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYC 170

  Fly    63 RLRKCLDIGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADS--SS 125
            ||:||.::||..|::.::      |.|.:...:|:...|:.....:.|...|:..||..::  |.
Mouse   171 RLQKCFEVGMSKESVRND------RNKKKKEPSKQECTESYEMTAELDDLTEKIRKAHQETFPSL 229

  Fly   126 SNLDHYSGSQDSQSCGSADSG--------ANGCSGR----QASSPGTQVNPLQMTAEKIVDQIVS 178
            ..|..|:.:..:......|.|        |..|..:    ....||       .|...|.|||.
Mouse   230 CQLGKYTTNSSADHRVRLDLGLWDKFSELATKCIIKIVEFAKRLPG-------FTGLTIADQIT- 286

  Fly   179 DPDRASQAINRLMRTQKEAISVME--KVISSQKDALRLVSHLIDYPGDALKI-ISKFMNSPFNAL 240
                       |::.....|.::.  ...:.::|.:..        .|.|.: .::..|:.|..|
Mouse   287 -----------LLKAACLDILILRICTRYTPEQDTMTF--------SDGLTLNRTQMHNAGFGPL 332

  Fly   241 T--VFT---KFMSSPTDGVE--IISKI---------VDSPADVVEFMQNLMHSPEDAIDIMNKFM 289
            |  |||   :.:....|..|  ::|.|         ::.|..|.:..:.|:.:.:  |.|..:..
Mouse   333 TDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVDKLQEPLLEALK--IYIRKRRP 395

  Fly   290 NTPAEALRILNRILSGGGANAAQQTADRKPLLDKE-PAVKPAAPAERADTVIQSMLGNS---PPI 350
            :.|....:||.:|......:|  :.|:|...|..| |...|        .:||.||.||   .|:
Mouse   396 SKPHMFPKILMKITDLRSISA--KGAERVITLKMEIPGSMP--------PLIQEMLENSEGHEPL 450

  Fly   351 SPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSP 385
            :|..:. ::..|||.|......:|.     ::.||
Mouse   451 TPSSSG-NIAEHSPSVSPSSVENSG-----VSQSP 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	37/92 (40%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
Rarb	NP_001276689.1	Modulating	1..114		2/7 (29%)
		NR_DBD_RAR	109..193	CDD:143522	37/89 (42%)
		Hinge	181..209		5/33 (15%)
		NR_LBD_RAR	213..443	CDD:132735	53/268 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	443..482		11/43 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847955
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930