DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hr96 and Thrb

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_033406.1	Gene:	Thrb / 21834	MGIID:	98743	Length:	475	Species:	Mus musculus

Alignment Length:	344	Identity:	89/344 - (25%)
Similarity:	132/344 - (38%)	Gaps:	114/344 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SPPKN---------------CAVCGDKALGYNFNAVTCESCKAFFRRNALAKK---QFTCPFNQN 48
            |||.:               |.||||||.||::..:|||.||.|||| .:.|.   .::|.:...
Mouse   101 SPPHSQKKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRR-TIQKSLHPSYSCKYEGK 164

  Fly    49 CDITVVTRRFCQKCRLRKCLDIGMKSENIMSEEDKLIKRRKIETNRAKRR--------------- 98
            |.|..|||..||:||.:||:.:||.::.::.:..:|.||:.||.||.|||
Mouse   165 CIIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPT 229

  Fly    99 -----LMENGTD---ACDADGGEERDHK--APADSSSSNLDHYSGSQDSQSCGSADSGANGCSGR 153
                 |::..|:   |.:|.|...:..:  .|.|...:.:              .::...|....
Mouse   230 DEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPI--------------VNAPEGGKVDL 280

  Fly   154 QASSPGTQVNPLQMT-----AEKI--------VDQIV-----------------SDPDRASQAIN 188
            :|.|..|::....:|     |:|:        .|||:                 .|||..:..:|
Mouse   281 EAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPDSETLTLN 345

  Fly   189 RLMRTQKEAISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFN------ALTVFTKFM 247
            ..|...:..:         :...|.:||..|...|.:|        |.||      ||......|
Mouse   346 GEMAVTRGQL---------KNGGLGVVSDAIFDLGMSL--------SSFNLDDTEVALLQAVLLM 393

  Fly   248 SSPTDG---VEIISKIVDS 263
            ||...|   ||.|.|..||
Mouse   394 SSDRPGLACVERIEKYQDS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	41/110 (37%)
		NR_LBD	462..>573	CDD:299703
		NR_LBD_F1	523..702	CDD:132727
Thrb	NP_033406.1	NR_DBD_TR	120..206	CDD:143519	36/86 (42%)
Thrb	NP_033406.1	NR_LBD_TR	230..472	CDD:132733	43/214 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847977
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840