DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hr96 and Nr1d1

DIOPT Version :9

Sequence 1:	NP_524493.1	Gene:	Hr96 / 42993	FlyBaseID:	FBgn0015240	Length:	723	Species:	Drosophila melanogaster
Sequence 2:	NP_663409.2	Gene:	Nr1d1 / 217166	MGIID:	2444210	Length:	615	Species:	Mus musculus

Alignment Length:	709	Identity:	143/709 - (20%)
Similarity:	224/709 - (31%)	Gaps:	261/709 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQKCRLRKCLDI 70
            |.||||.|.|:::....||.||.||||:.....|: .|..|:||.|..:.|..||:||.:|||.:
Mouse   133 CKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSV 197

  Fly    71 GMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSGSQ 135
            ||..:.:  ...::.||.|      :|.|.|.                    .|:.||   :.:|
Mouse   198 GMSRDAV--RFGRIPKREK------QRMLAEM--------------------QSAMNL---ANNQ 231

  Fly   136 DSQSCGSADSGA-NGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEAIS 199
            .|..|....|.. :..||....||.....|..:.......|.::.|...|..            .
Mouse   232 LSSLCPLETSPTPHPTSGSMGPSPPPAPAPTPLVGFSQFPQQLTPPRSPSPE------------P 284

  Fly   200 VMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVDSP 264
            .||.|||....|.|   .:..|..|      |...||.|       |.::...|         ||
Mouse   285 TMEDVISQVARAHR---EIFTYAHD------KLGTSPGN-------FNANHASG---------SP 324

  Fly   265 ADVVEF---MQNLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPA 326
            :.....   .|....:|.|                   |.:|:....|.|.....:.|  ...|.
Mouse   325 SATTPHRWESQGCPSAPND-------------------NNLLAAQRHNEALNGLRQGP--SSYPP 368

  Fly   327 VKPAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLP-YIANSPDFDLK 390
            ..|:.|.                           :||   ..||:::.....| ::.::|:
Mouse   369 TWPSGPT---------------------------HHS---CHQPNSNGHRLCPTHVYSAPE---- 399

  Fly   391 TFMQTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCNSA 455
                   .:.|:                         ||::|.          .|::....|
Mouse   400 -------GEAPA-------------------------NSLRQG----------NTKNVLLAC--- 419

  Fly   456 ANNSQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKPDDT 520
            ..|..||                        .|..|...|     :.||.|
Mouse   420 PMNMYPH------------------------GRSGRTVQE-----IWEDFS-------------- 441

  Fly   521 RHNPKLLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDRAAW 585
                     ::.|. |::.:::.||.|..|||:.|.|||.|||.|..|::::|...::
Mouse   442 ---------MSFTP-AVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLF------- 489

  Fly   586 KVPHTKENMGNIRTDLLKFAEGNIYEEHQ----------KFITTFDEKWR---MDENIILIMCAI 637
                      |::...:.|.....|...:          ..:..|.||..   :.|..:.:..|:
Mouse   490 ----------NVKDQTVMFLSRTTYSLQELGAMGMGDLLNAMFDFSEKLNSLALTEEELGLFTAV 544

  Fly   638 VLFTSARSRVIHKDVIRLEQNSYYYLLRRYLESVYSGCEARNA-FIKLIQKISDVERLN 695
            ||.::.||.:.:...:...|.:   |||.....|.....:..: |.||:.|:.|:..||
Mouse   545 VLVSADRSGMENSASVEQLQET---LLRALRALVLKNRPSETSRFTKLLLKLPDLRTLN 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	34/91 (37%)
		NR_LBD	462..>573	CDD:299703	24/110 (22%)
		NR_LBD_F1	523..702	CDD:132727	42/187 (22%)
Nr1d1	NP_663409.2	Modulating	1..129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..120
		Required for phosphorylation by CSNK1E and cytoplasmic localization. /evidence=ECO:0000269\|PubMed:30792350	1..70
		Crucial for activation of GJA1	49..285		52/194 (27%)
		NR_DBD_REV_ERB	128..216	CDD:143540	34/90 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..286		10/62 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..337		7/40 (18%)
		NR_LBD	419..612	CDD:299703	52/258 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847972
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840