Protein Alignment Hr96 and Rara

DIOPT Version :10

• Sequence 1: NP_524493.1
• Gene: Hr96 / 42993
• FlyBaseID: FBgn0015240
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_033050.2
• Gene: Rara / 19401
• MGIID: 97856
• Length: 462
• Species: Mus musculus
• Alignment Length: 392
• Identity: 92/392 - (23%)
• Similarity: 151/392 - (38%)
• Gaps: 102/392 - (26%)

  Fly     2 SPP------KNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQ 60
            |||      |.|.||.||:.||::....||.||.||||:......:||..::||.|..|||..||
Mouse    77 SPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQ 141

  Fly    61 KCRLRKCLDIGMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGE--ERDHKAPADS 123
            .|||:||.|:||..|::.::      |.|.:....|....|:.|  ...:.||  |:..||..::
Mouse   142 YCRLQKCFDVGMSKESVRND------RNKKKKEAPKPECSESYT--LTPEVGELIEKVRKAHQET 198

  Fly   124 --SSSNLDHYSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQA 186
              :...|..|:.:..|:...|.|                 ::.....:|.....|:...:.|.|.
Mouse   199 FPALCQLGKYTTNNSSEQRVSLD-----------------IDLWDKFSELSTKCIIKTVEFAKQL 246

  Fly   187 INRLMRTQKEAISVMEKV------------ISSQKDALRLVSHLIDYPGDALKI-ISKFMNSPFN 238
            ......|..:.|::::..            .:.::|.:..        .|.|.: .::..|:.|.
Mouse   247 PGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTF--------SDGLTLNRTQMHNAGFG 303

  Fly   239 ALT--VF---TKFMSSPTDGVE--IISKIVDSPADVVEFMQNLMHSPEDAIDIMNKFMNTPAEAL 296
            .||  ||   .:.:....|..|  ::|.|.....|..:..|      .|.:|::.:.:   .|||
Mouse   304 PLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQ------PDKVDMLQEPL---LEAL 359

  Fly   297 RILNRILSGGGANAAQQTADRKPLLDKEPAVKP-------------AAPAERADTVIQSMLGNSP 348
            ::..|              .|:|   ..|.:.|             |..|||..|:...:.|:.|
Mouse   360 KVYVR--------------KRRP---SRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMP 407

  Fly   349 PI 350
            |:
Mouse   408 PL 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	38/92 (41%)
		NR_LBD	462..>573	CDD:472173
		NR_LBD_F1	523..702	CDD:132727
Rara	NP_033050.2	Modulating	1..87		3/9 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..77		92/392 (23%)
		NR_DBD_RAR	82..166	CDD:143522	37/89 (42%)
		Hinge	154..182		6/35 (17%)
		NR_LBD_RAR	186..416	CDD:132735	48/275 (17%)
		UBR5-degron. /evidence=ECO:0000250|UniProtKB:P10276	254..258		0/3 (0%)
		Required for binding corepressor NCOR1	404..419		3/6 (50%)
		9aaTAD. /evidence=ECO:0000250|UniProtKB:P10276	408..416		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	420..462