Protein Alignment Hr96 and Ppara

DIOPT Version :10

• Sequence 1: NP_524493.1
• Gene: Hr96 / 42993
• FlyBaseID: FBgn0015240
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_035274.2
• Gene: Ppara / 19013
• MGIID: 104740
• Length: 468
• Species: Mus musculus
• Alignment Length: 318
• Identity: 73/318 - (22%)
• Similarity: 120/318 - (37%)
• Gaps: 90/318 - (28%)

  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQF-TCPFNQNCDITVVTRRFCQKCRLRKCLDI 70
            |.:|||||.||::....||.||.||||....|..: .|  :::|.|....|..||.||..|||.:
Mouse   102 CRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKC--DRSCKIQKKNRNKCQYCRFHKCLSV 164

  Fly    71 GMKSENI------MSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSN-- 127
            ||....|      .||:.||    |.|....:..|.::.|  .|.....:|.|:|...:.:.|
Mouse   165 GMSHNAIRFGRMPRSEKAKL----KAEILTCEHDLKDSET--ADLKSLGKRIHEAYLKNFNMNKV 223

  Fly   128 -----LDHYSGSQDSQSCGSADSGANGCSGRQASSPGTQVNPLQ---MTAEKIVDQIVSDPDRAS 184
                 |                      :|:.:::|...::.::   |..:.:|.::|::.....
Mouse   224 KARVIL----------------------AGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVEDK 266

  Fly   185 QAINRLMRTQKEAISVMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSS 249
            :|..|...             ..|..::..|:.|.::    .|.|..|.|...|......|:
Mouse   267 EAEVRFFH-------------CCQCMSVETVTELTEF----AKAIPGFANLDLNDQVTLLKY--- 311

  Fly   250 PTDGV-----EIISKIVDSPADVV---------EFMQNLMHSP-----EDAIDIMNKF 288
               ||     .::|.:::....::         ||::|| ..|     |...|...||
Mouse   312 ---GVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNL-RKPFCDIMEPKFDFAMKF 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	37/97 (38%)
		NR_LBD	462..>573	CDD:472173
		NR_LBD_F1	523..702	CDD:132727
Ppara	NP_035274.2	NR_DBD_Ppar	101..184	CDD:143523	33/83 (40%)
		NR_LBD_PPAR	201..467	CDD:132730	34/211 (16%)
		Required for heterodimerization with RXRA. /evidence=ECO:0000250	304..433		13/69 (19%)