DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hr96 and Nr1i2

DIOPT Version :9

Sequence 1:NP_524493.1 Gene:Hr96 / 42993 FlyBaseID:FBgn0015240 Length:723 Species:Drosophila melanogaster
Sequence 2:NP_035066.1 Gene:Nr1i2 / 18171 MGIID:1337040 Length:431 Species:Mus musculus


Alignment Length:721 Identity:143/721 - (19%)
Similarity:212/721 - (29%) Gaps:341/721 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 CAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQ-NCDITVVTRRFCQKCRLRKCLDI 70
            |.||||||.||:||.:|||.||.||||......:..|||.: .|:||..|||.||.|||||||:.
Mouse    38 CRVCGDKANGYHFNVMTCEGCKGFFRRAMKRNVRLRCPFRKGTCEITRKTRRQCQACRLRKCLES 102

  Fly    71 GMKSENIMSEEDKLIKRRKIETNRAKRRLMENGTDACDADGGEERDHKAPADSSSSNLDHYSGSQ 135
            |||.|.|||  |..:::|:....|.||..:|                                  
Mouse   103 GMKKEMIMS--DAAVEQRRALIKRKKREKIE---------------------------------- 131

  Fly   136 DSQSCGSADSGANGCSGRQASSPGTQVNPLQMTAEKIVDQIVSDPDRASQA-INRLMRTQKEAIS 199
                               |..||.|    .:|.|:             || |..||..|.:...
Mouse   132 -------------------APPPGGQ----GLTEEQ-------------QALIQELMDAQMQTFD 160

  Fly   200 VMEKVISSQKDALRLVSHLIDYPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKIVDSP 264
            .             ..||..|:.                                  :..:..|.
Mouse   161 T-------------TFSHFKDFR----------------------------------LPAVFHSG 178

  Fly   265 ADVVEFMQ-NLMHSPEDAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADRKPLLDKEPAVK 328
            .::.||:| :|:..|                             |..:|...||.|:        
Mouse   179 CELPEFLQASLLEDP-----------------------------ATWSQIMKDRVPM-------- 206

  Fly   329 PAAPAERADTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHPLPYIANSPDFDLKTFM 393
                                       .:.||..    ||..|.                     
Mouse   207 ---------------------------KISLQLR----GEDGSI--------------------- 219

  Fly   394 QTNYNDEPSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASRVKEEMSYGTQSTYGGCNSAANN 458
               :|.:|...||.         .|:|.:                                    
Mouse   220 ---WNYQPPSKSDG---------KEIIPL------------------------------------ 236

  Fly   459 SQPHLQQPICAPSTQQLDRELNEAEQMKLRELRLASEALYDPVDEDLSALMMGDDRIKPDDTRHN 523
             .|||                                       .|:|..|              
Mouse   237 -LPHL---------------------------------------ADVSTYM-------------- 247

  Fly   524 PKLLQLINLTAVAIKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMRSVMIYDDDRAAWKVP 588
                         .|.:|..||.|:.|||:..|||::||||...||.|:|...::|.:...|:..
Mouse   248 -------------FKGVINFAKVISYFRDLPIEDQISLLKGATFEMCILRFNTMFDTETGTWECG 299

  Fly   589 HT----KENMGNIRTDLLKFAEGNIYEEHQKFITTFDEKWRMDENIILIMCAIVLFTSARSRVIH 649
            ..    ::..|..:..||        :...||.... :|.::.:...::|.||.||:..|..|:.
Mouse   300 RLAYCFEDPNGGFQKLLL--------DPLMKFHCML-KKLQLHKEEYVLMQAISLFSPDRPGVVQ 355

  Fly   650 KDVIRLEQNSYYYLLRRYLESVYSGCEARNAFIKLIQKISDVERLNKFIINVYLNVNPSQ--VEP 712
            :.|:...|..:...|:.|:|........|..|:|::..::::..:|.......|.:..|.  ..|
Mouse   356 RSVVDQLQERFALTLKAYIECSRPYPAHRFLFLKIMAVLTELRSINAQQTQQLLRIQDSHPFATP 420

  Fly   713 LLREIF 718
            |::|:|
Mouse   421 LMQELF 426

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hr96NP_524493.1 NR_DBD_CAR 5..98 CDD:143524 49/91 (54%)
NR_LBD 462..>573 CDD:299703 23/110 (21%)
NR_LBD_F1 523..702 CDD:132727 43/182 (24%)
Nr1i2NP_035066.1 NR_DBD_like 37..124 CDD:383039 47/87 (54%)
Bipartite nuclear localization signal. /evidence=ECO:0000250 63..89 9/25 (36%)
Hinge 105..142 15/95 (16%)
NR_LBD 140..425 CDD:386099 86/557 (15%)
Hyperforin binding, agonist. /evidence=ECO:0000250|UniProtKB:O75469 282..285 1/2 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847978
Domainoid 1 1.000 99 1.000 Domainoid score I7064
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H40757
Inparanoid 1 1.050 171 1.000 Inparanoid score I4095
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D153746at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24082
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6384
SonicParanoid 1 1.000 - - X988
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1010.030

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