Protein Alignment Hr96 and nhr-48

DIOPT Version :10

• Sequence 1: NP_524493.1
• Gene: Hr96 / 42993
• FlyBaseID: FBgn0015240
• Length: 723
• Species: Drosophila melanogaster
• Sequence 2: NP_001362159.1
• Gene: nhr-48 / 181661
• WormBaseID: WBGene00003638
• Length: 833
• Species: Caenorhabditis elegans
• Alignment Length: 844
• Identity: 195/844 - (23%)
• Similarity: 306/844 - (36%)
• Gaps: 282/844 - (33%)

  Fly     5 KNCAVCGDKALGYNFNAVTCESCKAFFRRNALAKKQFTCPFNQNCDITVVTRRFCQKCRLRKCLD 69
            |.|.||||||..||||.:|||||||||||||..:|:..||||:.|:|.:|:|||||:|||.||..
 Worm   108 KVCRVCGDKAFSYNFNVITCESCKAFFRRNANKEKEIRCPFNEQCEINMVSRRFCQRCRLTKCFA 172

  Fly    70 IGMKSENIMSEEDKLIKRRKIETNRAKR------RLMENGTDACDADGGEERDHKAPADSSSSNL 128
            :|||.|.|||||.:|.|::::|.||.:|      |.:|   :||..|..|....:|||.|...::
 Worm   173 VGMKKEWIMSEEARLEKKQRVEENRERRLQDAMNRALE---EACMEDESENSYDEAPAPSHQMSV 234

  Fly   129 DHYSGSQDS---------------------------QSCGSADSG-----------ANGCSGRQA 155
            ..|..:.|:                           ...|.:|.|           :|.|:  .:
 Worm   235 RQYLANDDAPHKSSDEVQPHLGHHGYNQKEDKMMNFYQDGPSDQGYSNHDFDYSLPSNSCA--SS 297

  Fly   156 SSPGTQVNPLQMTAEKIVDQIVSDPDRASQAINRLMRTQKEAISVMEKVISSQKDALRLVSHLID 220
            |...|.||   ..|..|.|...|..:..         |...|:.|..|.|
 Worm   298 SQLDTSVN---CGATTIADNGASPSNTV---------TIPAAVDVERKPI--------------- 335

  Fly   221 YPGDALKIISKFMNSPFNALTVFTKFMSSPTDGVEIISKI------VDSPADVVEFMQNLMHSPE 279
                           |.|.|  |:..||:..|...|||..      :.:| |||.  :|||:..:
 Worm   336 ---------------PTNVL--FSASMSAIQDVAAIISNAETKNLGMCAP-DVVN--ENLMNVAQ 380

  Fly   280 DAIDIMNKFMNTPAEALRILNRILSGGGANAAQQTADR--------KPLLDKEPAVKPAAPAERA 336
            .|:           :|..|:|.......|..|||....        .||   :|.:.||..|...
 Worm   381 AAV-----------QAQAIVNHTQQLAAAVVAQQVVSNMAPVMPTVNPL---DPLLAPAFIAPPM 431

  Fly   337 DTVIQSMLGNSPPISPHDAAVDLQYHSPGVGEQPSTSSSHP-LPYIANSPDFDLKTFMQTNYNDE 400
            .|.|     |.|..:|...|:......|.|  .|..||.:| :|.|.......:..
 Worm   432 PTPI-----NVPITTPIAGALSTPLPPPIV--PPGHSSINPVIPIIPKEMPVSVSL--------- 480

  Fly   401 PSLDSDFSINSIESVLSEVIRIEYQAFNSIQQAASR-----------------VKEEMSYGTQST 448
                    :|.:|...:|::.:.......:.|..||                 :.:|:   |:..
 Worm   481 --------LNQLEQTPAEMVTVPKDMLMKLIQKNSRSTCTCSCMCGRYPPGSCIVDEV---TKDL 534

  Fly   449 YGGCNSAANNSQPHLQQPICAPSTQQLDRELNEAEQMKLREL--------------RLASEALYD 499
            ..|.:|.::|            :|.:.:..|...|.|::..|              :.:::|..|
 Worm   535 LNGGSSNSSN------------ATDRDETRLETTEDMQMNGLLPGDCNSSIQWLNQQSSAQAFVD 587

  Fly   500 PVDEDLSALMMGDDRIKPDD-----------TRHNPKLLQ------------------------L 529
            |:...::|......|.:.|.           |...||.:|                        :
 Worm   588 PITHSMTAEEAQTQRERRDSIFGSFSAADQGTVTQPKSVQEETIWEHTVAENESRELSDEEIEKM 652

  Fly   530 INLTAVA---------------------IKRLIKMAKKITAFRDMCQEDQVALLKGGCTEMMIMR 573
            ..||.::                     :::::...|.:::||.:.|.|:.:::|.|.....:::
 Worm   653 EELTEISNQWISMRLDSMPILDLFSKKNVEKIVNGLKLLSSFRFLPQVDKRSVVKRGLFNYCVVK 717

  Fly   574 SVMIYDDDRAAWKVPHTKENMGNIRTDLLKFAEGNIYEEHQKFITTFDEKWRMDENIILIMCAIV 638
                       | :.| ||:|.   .|.|..|   ...:....|...:..:|:.......:...|
 Worm   718 -----------W-MQH-KESMS---IDGLSDA---ARRDFMNIIRREEFNYRVQPGAFNTLAISV 763

  Fly   639 LFTSARSRVIHKDVIRLEQNSYYYLLRRYL------ESVYSGCEARNAFIKLIQKISDVERLNK 696
            ||.|....:|..||. :|...:..||.:.|      ::||:     |.:..:|:....:|:..|
 Worm   764 LFHSISDNLISTDVY-MEHLVFKKLLDKNLPIKVSSDTVYN-----NYYPYIIKAAKHLEKATK 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hr96	NP_524493.1	NR_DBD_CAR	5..98	CDD:143524	58/98 (59%)
		NR_LBD	462..>573	CDD:472173	24/180 (13%)
		NR_LBD_F1	523..702	CDD:132727	39/225 (17%)
nhr-48	NP_001362159.1	NR_DBD_CAR	108..200	CDD:143524	57/91 (63%)