DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tnc and Rp1

DIOPT Version :9

Sequence 1:	NP_001247300.1	Gene:	tnc / 42990	FlyBaseID:	FBgn0039257	Length:	2819	Species:	Drosophila melanogaster
Sequence 2:	XP_008761780.1	Gene:	Rp1 / 681377	RGDID:	1596713	Length:	2150	Species:	Rattus norvegicus

Alignment Length:	1999	Identity:	389/1999 - (19%)
Similarity:	655/1999 - (32%)	Gaps:	606/1999 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   526 EETED-EAKPTS-----APVASDEKEQEPKP--SEGSGDEELDLK------PTTAPTAGATSASE 576
            ||.|| |:...|     .||..|:..:.|:|  |..|....:.|:      |||||  |...|..
  Rat   120 EELEDGESYVCSHNKKVLPVDLDKARRRPRPWLSSRSISTHVKLRSATATMPTTAP--GLFRAPR 182

  Fly   577 ESEEQDEG---------------KSTEA----PTSVDDIEPAKPTESSEEASGEGEDVAKETTPA 622
            .......|               :|.||    .|.|.....||...:      :|..|     |:
  Rat   183 RLVVFRNGDPKTRRVVLLSRRITQSFEAFLQYLTQVMQYPVAKLYAT------DGRKV-----PS 236

  Fly   623 GEASIAGEEEIVKGTTPAG-EPSSEGDEEIVKGTTPAE--------ESSSESEDELTKVTTPA-- 676
            .:|.|.....:|    .|| ||...|:.:|.|...|.:        ....:::.|..|::|.:
  Rat   237 LQAVILSSGAVV----AAGREPFKPGNYDIQKYLLPVKLPGISHRVHRKGKAKIEKRKMSTHSVP 297

  Fly   677 ----------------GEPSVAGEEEIAKET----TPAGEPSIAG-------------------- 701
                            .:.|||.|..:|.||    |.:..||..|
  Rat   298 RPQTDSLASEKTYDCFSDFSVAPENYLALETHDSQTLSTYPSEDGVEKSIVFNQDGTMTVVMKVR 362

  Fly   702 ---EEEIVKVTTPAGESSIAGEEEIVKVTTPAGESSSEGEEEIIKVTTPAGESSSEGDEEIVKES 763
               :||.||.||....:.::.::|..|:::..|:  :|.....:|:..|...|      |.:.::
  Rat   363 FKIKEETVKWTTTVNRADLSNDDEKSKISSYPGK--TEDRSSSLKLVVPCSLS------EDITDT 419

  Fly   764 TPAGEPISEGEEDVIKATTSAPKSDIEGVKEP--ETATEVPAEEVEDFAKPTTPIAE--AEEEPI 824
            |..|. ::| ||:.......|..|...|.:..  |...:...::|:.|.:|.||...  .:::.:
  Rat   420 TQQGS-LTE-EENTQMTEQQALSSSSAGWENASMEVGIQGSQKQVKHFYRPPTPGPRRMRQKKSV 482

  Fly   825 AGTPIPTDGISGEEEIVKGTTPQ----TLEEQPEISEESTE-----------------VPVAEDD 868
            .||          ..:|..|..|    :..|:.|:.|:|..                 |.::.||
  Rat   483 IGT----------VTVVSETEVQEKQFSYREEREVGEKSKYHMFTHSCSKMSSVSNKLVQISSDD 537

  Fly   869 LSSS----TSASAIASSTEGVQDAASETTSSAPARAGDKDEAATTVP----TAQDKDDEEVEQDA 925
            ...|    |..|....| ..:...|.|.||....:....:..|:|||    ..:..||..:...|
  Rat   538 ERESALERTKESGPLKS-HAINAGAIEITSQRVLKMCHNNALASTVPENSVVEEGTDDSAISGKA 601

  Fly   926 TDL------PVEDVVQSTTAKTTTTEQ---PKEESSTEAEDAEIEVTTSS-------------PA 968
            |..      ...|...||||.||.|..   |...:.:|.......|.|:.             |.
  Rat   602 TIKHFRTCGNANDSFSSTTADTTLTSGNNCPNVRTISEVPSVGSPVLTTGLVNEFAHCGLTEHPG 666

  Fly   969 DKQEVPEAEPADKDHKDEEDVQTATDLPIKSDIGPPVVDTEATTGQPETSDETATDKPPSVYLPP 1033
            :.:::.....:.|..|.::.:.|:.|       ...|::|:....:........|.....:....
  Rat   667 NGRQISSPFASKKKKKSQQRMITSKD-------KKKVIETKGIPNKVGKIHRAGTIAQVVLLQDS 724

  Fly  1034 GG-EKDTEKEDETTATEPSVQEEPSKPVDISPVSQEVPSSTAKVDNRNDFET-EKPTLPPSGEDQ 1096
            || :|:....:|...|.|.|.|..    ||.|...   |..:|..::|...| :.|........:
  Rat   725 GGLDKEGRVREEELDTSPMVIESH----DIFPKGN---SKFSKNFHKNKLNTVQNPKTQKLLAKR 782

  Fly  1097 SSEPLPAMDLPAGIPGEGDCLVEGKTYANNTIVPATAPCDVSCKCISSLVACQQMECKLPE-NLE 1160
            .|.||....:  |...:.:...|.|.:.::                         |.||.| |||
  Rat   783 KSRPLKIKSI--GELRKQETGQEDKVFLHS-------------------------ESKLCESNLE 820

  Fly  1161 KCTVAADLLDGCCPTYICDESTESAEKDEESTAKPDNKIDEDVSE-------------------- 1205
            |.::.              ....|.|:|:::..:..::: |.|:|
  Rat   821 KQSLL--------------HVFSSLEEDQKALHRSQSQV-ETVTENWKGMTKKSLVPKVNDLHVT 870

  Fly  1206 ISTEEIPKDVIMPTG--ITEQ-------PLSHV-KPD------------------EEIQPV---- 1238
            :..:...|.|.:.:|  ::||       ||:.: |||                  :.|.|.
  Rat   871 VRNQRKQKGVKLKSGATVSEQHIATRADPLASLKKPDLTEGIPHHSVKSYIQRWLQNINPYPDFE 935

  Fly  1239 --TSVPAQFDES----------------TTAKVDKKPIDESAEDKKPI-----GESEEDSKPIDE 1280
              .|.|...|.|                ||:...|..:.||.:.|...     .:::|.||.:..
  Rat   936 HRKSAPLGQDRSNVVNYNSNGFPENNLPTTSSKGKSFLMESNKRKTKNANWKGNKNQETSKSLVV 1000

  Fly  1281 SEEDKKPVEESAEDKK---------PVEDS-EEKEKPLPTVIPASEIEKESKPEDEKKTEADFAA 1335
            .:..::|.:.|.|.:.         |:.|: ...:..:......|.:..|....:.|....:...
  Rat  1001 KDNGEQPNKHSCESQDESLYDSYLGPLHDNCTLSQTSINDPCTKSHLSTEKSRPEVKLVYQEMNF 1065

  Fly  1336 PTEQPEATTPAQIADTAEKEVDDKLATTSAPVSGEDELKPADEKKRTETAQIPD--AEIPASTDE 1398
            .|::.......|:....|....|.||..   :...:...|.::|.:...:|:|.  ||:...:..
  Rat  1066 STKRQTLEVAIQVDTMGENVPKDLLALL---LQHLEAFIPNNQKHQNGISQLPGSLAEVVFPSAI 1127

  Fly  1399 PESSTELP---TVDLDKKPEEDSTKGTEAPESDKVPEVPTSASTENE-----------IEESDKF 1449
            ..|||.|.   .:.|:.|...:|...::||::       ||.|:|..           .||:|..
  Rat  1128 YNSSTNLLLAWLLVLNLKRNMNSFCQSDAPKT-------TSRSSETAALLDVLKHVAITEEADDL 1185

  Fly  1450 TTVAPPKISA-------SDETEPTAEEDLVPATFEPIES-EFEVSTKKP------AVQGPPLPTL 1500
            .......:.:       |...:.||..:.:.|:...::. :...||:|.      :|:|...|.|
  Rat  1186 KAAVANLVESTKTCSGPSGREQDTAPANCIAASLHSVDKCKENKSTQKSLLDEGYSVRGDCGPEL 1250

  Fly  1501 APAQPEKK----------------PVDAETSTEADISTEPSAEVEKEAS------GET------- 1536
            ...:...|                |.......:|..::..|:.:.:.::      ||.
  Rat  1251 CVLEMVSKSNNTPSEGHTVSMTYPPKGVNNQNDALFTSNDSSTMSQRSTHNASFLGEACLLTDSL 1315

  Fly  1537 ------SESDNEIDAGASSTPVPVSADEDKTPSTE-KTVE----ADDKFTTVAPLAGDEEESNLP 1590
                  ::.||..:|...|       ||...|..: ||:|    .::|.|....|.  ||...:.
  Rat  1316 CSHKACAQKDNIYEAACLS-------DETHIPIRDCKTIEFVNSKENKCTDNLELT--EEIKTVD 1371

  Fly  1591 KLPQD-------IFEEEAPVAVTTAAPSK--------------DDGEQKPVE----------VEE 1624
            |:|:|       |.:.|:.::.::...:|              .|.:..|:|          |.:
  Rat  1372 KVPKDLNILADSIDKNESDISTSSQNVNKLSSQGIFLSKTHLDSDKDYSPLEEFQNCPPKKIVNK 1436

  Fly  1625 KPIEDGQKPIEDETSTPTSSENEIEPESDRATTIAPSKEEPSEPSTG-----APTKDEPAEPSTD 1684
            |......|.....:..|.|..|.:......||:...|.||.....||     ..|:::.|:.|..
  Rat  1437 KKSVSSDKEDSRTSEEPRSITNSVTSSERNATSELESFEESESQDTGIFNMKVRTEEKAAKESMQ 1501

  Fly  1685 APESDESKETPESEVPTTVAPAGEKIPTSSITPDEE--------PTATSAPVAKP--------DE 1733
                      .|||...::    |.|..|.....|:        .|.....|..|        ::
  Rat  1502 ----------KESEARMSL----ELINISGRNIIEQGRRNTAFLETTGRGQVTPPSLVFCYDSNK 1552

  Fly  1734 DVEKETS---TEIPTDAPASSEEDENSSTDQIPSEVPEKKPET----------------PAQTPE 1779
            :.|||.|   |::.......|.|:|:.:...:......:.|.|                .|.:.|
  Rat  1553 NTEKEMSVGETKMRVKKIVDSMENESYTDSSLNCNKQHRSPGTLDWSDYGSDSESRYPCKALSYE 1617

  Fly  1780 EGDIVGATAAPTTSDEVPP--VQRLPEEVL--AEIPQPSTETGIKQQDETTAAPSIDRKE--PYV 1838
            ..|..|      ...|.|.  |:|..|::.  |||.:|....|           ||.:.:  ||
  Rat  1618 HSDDTG------QEREYPRGIVRRAIEKLYGKAEIIKPPFFHG-----------SIHKSQVCPY- 1664

  Fly  1839 TEIDEEATTVAPISEKDEKPTE-EEKPVEQKPTGEEPS------EEEEKEKPIEQDVSTEGPVST 1896
                      .|:.....|.|. .|...:...:.|:.|      :|.::|:..|.|.:..|
  Rat  1665 ----------NPVEVPCVKKTHFYESECQSLVSSEQVSRSSLMLQEFQEERQSEVDANGMG---- 1715

  Fly  1897 EASEAGSTESSEEVKPSTEGEV-AEKPEDKQPSSTAQAPVET-IPEISTELPAQDGDKPTSEAPV 1959
              ...|.:...:..|||..|.| .||.:.|...:......|. :..:|.:.|...|:..|:....
  Rat  1716 --DSFGDSSIEKVTKPSEHGRVFMEKEKGKLIDNGKWLLRENHLWRVSLDNPGMYGNADTTSVDT 1778

  Fly  1960 DSDEDTSAPSDEKIP-SVSGEEVEGPEVTTASPQAAEEDELKTPAESE------PSSTDKVPETE 2017
            ..|:::.     ::| |..||...||  |.|...::|.:|:..|.|.:      |..:|
  Rat  1779 LMDKNSI-----EVPYSHFGELAPGP--TMAELSSSEIEEMTQPLEVKCNYFNFPHGSD------ 1830

  Fly  2018 YQKPEDETKADETPESVTQVSDVATSTSAPVAGGDIEKDEQATTASPEEEEEIKPTIAPAAEIPQ 2082
             .:|..|...|            |.:|:.|        .|:......||:..            .
  Rat  1831 -SEPFGEDFLD------------AQNTNCP--------KEKIPNHHKEEKRN------------S 1862

  Fly  2083 PSEK--EPVDEQEVESGTKATPAESD---GQPIDEIAPATSGPIDEAST 2126
            |||:  .||.:....:|.|..|..||   .||:.. :..|.|.:.|..:
  Rat  1863 PSERTCTPVTQTFASAGNKVHPVCSDVIKTQPLPG-SSITHGALQEGDS 1910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tnc	NP_001247300.1	VWC	235..296	CDD:214564
		PHA02664	<433..595	CDD:177447	27/101 (27%)
		Ehrlichia_rpt	529..1065	CDD:118064	141/678 (21%)
		DUF863	<1684..>1788	CDD:283539	24/138 (17%)
		VWC	2762..>2805	CDD:302663
Rp1	XP_008761780.1	DCX	60..135	CDD:176357	6/14 (43%)
Rp1	XP_008761780.1	DCX	182..257	CDD:176357	18/89 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900