DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tnc and KCP

DIOPT Version :9

Sequence 1:	NP_001247300.1	Gene:	tnc / 42990	FlyBaseID:	FBgn0039257	Length:	2819	Species:	Drosophila melanogaster
Sequence 2:	XP_016867673.1	Gene:	KCP / 375616	HGNCID:	17585	Length:	1633	Species:	Homo sapiens

Alignment Length:	1335	Identity:	257/1335 - (19%)
Similarity:	366/1335 - (27%)	Gaps:	511/1335 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 GCYYNYAHYQEGDRIM-TNEPCLNCTCHNRMLMCYLRVC---PFTKPI---GHDCIVEKREDQCC 103
            ||.|....|:||...: ::.|||.|||....:.|....|   |..:|:   ||          ||
Human   191 GCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMALKCPPSPCPEPVLRPGH----------CC 245

  Fly   104 PIITCPEVPVDVPYHSPEPGTELSIPEKFGCSIEEKFYPEGAQVPSNPNKPCELCYCINNQTKCV 168
            |  ||.                       ||: |...:.|..|..:.|..||.:|.|:....:|.
Human   246 P--TCQ-----------------------GCT-EGGSHWEHGQEWTTPGDPCRICRCLEGHIQCR 284

  Fly   169 MQECTLHVDGC------LPIYNKGSCCPVRYSCDHENELDFMDQSTTTTTTTVRPTTGFILASTM 227
            .:||   ...|      ||    |:||||   ||
Human   285 QREC---ASLCPYPARPLP----GTCCPV---CD------------------------------- 308

  Fly   228 TPPTTTDCIHDGEIFADGASLKGKNACEHCYCMRGDIVCAVQEC-EVPMMAANGKSCRAMPAAEG 291
                  .|..:|.....|..:...:.|.||.|..|.:.|....| .||        ||......|
Human   309 ------GCFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVP--------CRHPGKIPG 359

  Fly   292 ECCPSNYVCEDDSSTTEIVEITTPESATSVPAKGIHAEIPKEDVDLQEHIDDDDKNKETATIPSA 356
            :|||....||...                      |....:|...|||.          ......
Human   360 QCCPVCDGCEYQG----------------------HQYQSQETFRLQER----------GLCVRC 392

  Fly   357 ELGSGEIEEEEEEKDKATTVAPVQVTDEKDFSFEPESSTAGIPSDSRIDLPSSTEESKESSTEAA 421
            ...:||:..||:|       .||              :...:|:..| .|..:.|...|...|..
Human   393 SCQAGEVSCEEQE-------CPV--------------TPCALPASGR-QLCPACELDGEEFAEGV 435

  Fly   422 EEDIVKIVTTPEPEGSG------EEDVPK---------PSQIPEKEITEDELIKVSTSAPAKASP 471
            :.         ||:|..      ::.|||         |.|.|             |..|....|
Human   436 QW---------EPDGRPCTACVCQDGVPKCGAVLCPPAPCQHP-------------TQPPGACCP 478

  Fly   472 E------EEVVTATTSAPTEEDVKPTTA-----GTISEEEEEGKPTPA---EEGSG--------- 513
            .      ...|.|.....|:.| .|..|     ||::....:..||..   :.|.|
Human   479 SCDSCTYHSQVYANGQNFTDAD-SPCHACHCQDGTVTCSLVDCPPTTCARPQSGPGQCCPRCPDC 542

  Fly   514 --EEE--KDVKVTAAPEETEDEAKPTSAPVASDEKEQEPKPSEGSGDEELDLKPTTAPTAGATSA 574
              |||  .|.:..:.|.:...|.:     ........:|:|...:        |...|..|....
Human   543 ILEEEVFVDGESFSHPRDPCQECR-----CQEGHAHCQPRPCPRA--------PCAHPLPGTCCP 594

  Fly   575 SEESEEQDEGKSTEAPTSVDDIEPAKPTESSEEASGEGEDVAKETTP---AGEASIAGE--EEIV 634
            ::.|.....||  |.|:..|...|:.|.......||..:.:|:...|   .....:.||  .:..
Human   595 NDCSGCAFGGK--EYPSGADFPHPSDPCRLCRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQCP 657

  Fly   635 KGTTPAGEP-------------SSEGDEEIVKGTTPAEE----SSSESEDELTKVTTPAGEPS-- 680
            ....|||.|             |..||        |...    ..|.|...|.....|...|.
Human   658 AAPAPAGCPRPGAAHARHQEYFSPPGD--------PCRRCLCLDGSVSCQRLPCPPAPCAHPRQG 714

  Fly   681 ----------VAGEEEIAKETTPA----------GEPSIAGEEEIVKVTTPA------------- 712
                      ..|:|..:.|..|:          .|.|::.|.   |...||
Human   715 PCCPSCDGCLYQGKEFASGERFPSPTAACHLCLCWEGSVSCEP---KACAPALCPFPARGDCCPD 776

  Fly   713 -------GESSIAGEE-----EIVKVTTPAGESSSEGEEEIIKVTTPAGESSSEGDEEIVKESTP 765
                   |||.::.:|     |...:.|..|...:.|.    :...|.|.|         ....|
Human   777 CDGCEYLGESYLSNQEFPDPREPCNLCTCLGGFVTCGR----RPCEPPGCS---------HPLIP 828

  Fly   766 AGE--PISEGEEDVIKATTSAPKSDIEGVKEPETATEVPAEEVEDFAKPTTPIAEAEEEPIAGTP 828
            :|.  |..:|             ....||      |....|.:.|...||..:...:|
Human   829 SGHCCPTCQG-------------CRYHGV------TTASGETLPDPLDPTCSLCTCQE------- 867

  Fly   829 IPTDGISGEEEIVKGTTPQTLEEQPEISEESTEVPVAEDDLS------SSTSASAIASSTEGVQD 887
                   |.....|...|..|...|  |......||....||      ........|.|.|..:.
Human   868 -------GSMRCQKKPCPPALCPHP--SPGPCFCPVCHSCLSQGREHQDGEEFEGPAGSCEWCRC 923

  Fly   888 AASETT------SSAPARAGDKDEAATTVPTAQD--KDDEEVEQDATDLPVEDVVQS-------- 936
            .|.:.:      ...|.:. ...|..:..|..:.  ...||..:.:..:|.:....|
Human   924 QAGQVSCVRLQCPPLPCKL-QVTERGSCCPRCRGCLAHGEEHPEGSRWVPPDSACSSCVCHEGVV 987

  Fly   937 TTAK---TTTTEQPKE---ESSTEAEDAEIEVTTSSP-------ADKQEV------PEAEPADKD 982
            |.|:   .::..||::   :...:..|.|.|.....|       ||..||      ||..|:.:.
Human   988 TCARIQCISSCAQPRQGPHDCCPQCSDCEHEGRKYEPGESFQPGADPCEVCICEPQPEGPPSLRC 1052

  Fly   983 HKDEEDVQTATDLPIKSDIGPPVVDTEATTGQPETSDETATDKPPSVYLPPGGEKDTEKEDETTA 1047
            |:.:               .|.:|..                 |||..||||
Human  1053 HRRQ---------------CPSLVGC-----------------PPSQLLPPG------------- 1072

  Fly  1048 TEPSVQEEPSKPVDISPVSQEVPSSTAKVDNRNDFETEKPTLPPSGED-----------QSSEPL 1101
                       |....|...|..|:.::....::.....|......:|           :.|.||
Human  1073 -----------PQHCCPTCAEALSNCSEGLLGSELAPPDPCYTCQCQDLTWLCIHQACPELSCPL 1126

  Fly  1102 PAMDLPAG----------IPGEGDCLVEGKTYANNTIVPATAPCDVSCKCISSLVACQQMECK-- 1154
            .....|.|          :..||..:.:|:::.:    |:.| | ::|.|....|.|...||:
Human  1127 SERHTPPGSCCPVCRECVVEAEGRRVADGESWRD----PSNA-C-IACTCHRGHVECHLEECQAL 1185

  Fly  1155 -LPENLEKCTVAADLLDGCC----------PTYIC 1178
             .|....|...|    |.||          ||..|
Human  1186 SCPHGWAKVPQA----DSCCERCQAPIPSAPTQSC 1216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tnc	NP_001247300.1	VWC	235..296	CDD:214564	17/61 (28%)
		PHA02664	<433..595	CDD:177447	40/203 (20%)
		Ehrlichia_rpt	529..1065	CDD:118064	113/647 (17%)
		DUF863	<1684..>1788	CDD:283539
		VWC	2762..>2805	CDD:302663
KCP	XP_016867673.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46698
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100