DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tnc and Asph

DIOPT Version :9

Sequence 1:	NP_001247300.1	Gene:	tnc / 42990	FlyBaseID:	FBgn0039257	Length:	2819	Species:	Drosophila melanogaster
Sequence 2:	NP_001261020.1	Gene:	Asph / 36778	FlyBaseID:	FBgn0034075	Length:	991	Species:	Drosophila melanogaster

Alignment Length:	679	Identity:	152/679 - (22%)
Similarity:	242/679 - (35%)	Gaps:	206/679 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   735 SEGEEEIIKVTTPAGES-------------SSEGDEEIVKESTPAGEPISEGEEDVIKATTSAPK 786
            :.|.|::   .||..||             ..|.|...|:|  |:||.:.:.:|          .
  Fly    74 NRGLEDL---DTPLSESRFSKVFDGWVDEHRDEHDGHDVQE--PSGEALDDHDE----------H 123

  Fly   787 SDIEGVKEPETATEVPAEEVEDFAKPTTPIAEAEEEPIAGTPIPTDGISGEEEIVKGTTPQTLEE 851
            .|.:..::.|..||...||:|:..:||     .|:||.|......|    |:|........|.|:
  Fly   124 DDHDDHEDEEPLTEELEEELEEEEEPT-----EEDEPAADEEYEED----EDEENNAGENITAED 179

  Fly   852 QPEISEESTEVPVAEDDLSSSTSASAIASSTEGVQDAASETTSSAPARAGDKDEAATTVPTAQDK 916
            ..|..||       ||:....|..:.:.::||    |.:|.|....|...|:||||.
  Fly   180 AEEEEEE-------EDNDDEGTVEATVEATTE----ATTEATGEYEAEEDDEDEAAA-------- 225

  Fly   917 DDEEVEQDATDLPVEDVVQSTTAKTTTTEQPKEESSTEAEDAEIEVTTSSPADKQEVPEAEPA-D 980
            ||             |.|:||.|..:..|:.:::...:.|:.|||.:. .|...|...::.|| |
  Fly   226 DD-------------DAVESTEAPLSKAEEQEDDEDEDEEEQEIEESV-EPERSQYAAQSAPAKD 276

  Fly   981 KDHKDEEDVQTATDLPIKSDIGPPVVDTEATTGQPETSDETATDKPPSVYLPPGGEKDTEKEDET 1045
            .:..|::|.|...|.....|     .:.|:...|.|...|...         |....::|::|:.
  Fly   277 NNDDDDDDDQDKNDADDGDD-----DEFESLAQQFENDPEDTV---------PAKAVESEEQDQD 327

  Fly  1046 TATEPSVQEEPSKPVDISPVSQEVPSSTAKVDN----RNDFETEKPTLPPSGEDQSSEPLPAMDL 1106
            .|.|...:||.|..:....|...|..:.|.|..    |..        |.:.||   ||.|
  Fly   328 QADEEEPKEEGSSWLASLAVKFGVGVALALVSRLVLIRKS--------PNTTED---EPAP---- 377

  Fly  1107 PAGIPGEGDCLVEGKTYANNTIVPATAPCDVSCKCISSLVACQQMECKLPENLEKCTVAADLLDG 1171
                          :|.....:..|||                  |..:|:::|:.....|
  Fly   378 --------------ETIFRRRLTIATA------------------EDHIPDDVEELPPLDD---- 406

  Fly  1172 CCPTYICDESTESAEKDEESTAKPDNKIDEDVSEISTEEIPKDVIMPTGITEQPLSHVKPDEEIQ 1236
                   :.|.|..|.:||        |:.::|:|..|             |:.:.|...|....
  Fly   407 -------EYSEEEIEIEEE--------IEVEISDIEEE-------------EEEVRHDNDDNVAS 443

  Fly  1237 PVTSVPAQFDE-STTAKV------DKKPIDESAEDKKPIGES----EEDSKPIDESEEDKKPVEE 1290
            ..:.||..|:: |...|.      |.||..:..|.:||:|.|    |.:...|::.|.|....||
  Fly   444 MASYVPETFEQLSAMYKYAQEPTKDAKPEQKEKEPEKPVGHSDIYVEYEDGAIEDYEHDGVSDEE 508

  Fly  1291 SAEDKKPVEDSEEKE-----KPLPTVIPASEIEKESKPEDEKKTEADFAAPTEQPEATTPAQIAD 1350
            ..:::..:.|.::.:     :.....:|..|.|.:...:|...|:.       :|:...||
  Fly   509 ITDEEDEISDVDDADLMNRLEAKYGRLPVKEFESDPDSDDPSWTQI-------KPKEAAPA---- 562

  Fly  1351 TAEKEVDDKLATTSAPVSGEDELKPADEK 1379
            .||||  |..         |.||:.|:|:
  Fly   563 PAEKE--DPF---------EQELRKANEE 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tnc	NP_001247300.1	VWC	235..296	CDD:214564
		PHA02664	<433..595	CDD:177447
		Ehrlichia_rpt	529..1065	CDD:118064	83/343 (24%)
		DUF863	<1684..>1788	CDD:283539
		VWC	2762..>2805	CDD:302663
Asph	NP_001261020.1	TPR	610..854	CDD:223533
		TPR repeat	684..714	CDD:276809
		TPR repeat	719..748	CDD:276809
		TPR repeat	757..782	CDD:276809
		Asp_Arg_Hydrox	826..977	CDD:282913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900