DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tnc and CG17211

DIOPT Version :9

Sequence 1:	NP_001247300.1	Gene:	tnc / 42990	FlyBaseID:	FBgn0039257	Length:	2819	Species:	Drosophila melanogaster
Sequence 2:	NP_609552.1	Gene:	CG17211 / 34639	FlyBaseID:	FBgn0032414	Length:	1354	Species:	Drosophila melanogaster

Alignment Length:	1500	Identity:	317/1500 - (21%)
Similarity:	499/1500 - (33%)	Gaps:	493/1500 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTRRRSSPPGLEELLYLALVLLAMILIPTQAAPVQEYTEIQQYSEGCYYNYAHYQEGDRIMTNEP 65
            ||.|      |..:|..||:||....:.....|          :.||::|...:.:...:.:.|.
  Fly     1 MTLR------LVSILSAALLLLWPAQLDAFITP----------NTGCHHNGTWFADKSVVPSMEK 49

  Fly    66 CLNCTCHNRMLMCYLRVCP-FTKPIGHDCIVEKREDQCCPIITCPEVPVDVPYHSP--------- 120
            ||||.|:.:.|:|.|:||| ...|....|:|.:::..|||.::|..  :|..|..|
  Fly    50 CLNCQCNRKTLVCRLKVCPEMPMPPPRGCVVVQKKSSCCPYLSCAR--LDAFYKIPTKRRIIAYL 112

  Fly   121 -----------------EPGTELSIPEKFGCSIEEKFYPEGAQVPSNPNKPCELCYCINNQTKCV 168
                             :..::.|..:.|.|......|..|:.:.|  :..|..||||....|||
  Fly   113 DHYERESIDRVVNDNMLQRRSDDSDTDLFVCVKNGTVYKSGSAMSS--SNLCSYCYCIGGTEKCV 175

  Fly   169 MQECTLHVDGCLPIYNKGSCCPVRYSCDHENELDFMDQSTTTTTTTVRPTTG-FILASTMTPPTT 232
            ..:|.|.|:||.||:...:||||||.|..:.      ...::.....|.|:. ..|..:......
  Fly   176 KPKCMLPVEGCKPIFVDSTCCPVRYDCSSKT------SGKSSQEVRYRKTSNKHFLRMSQRLQRN 234

  Fly   233 TDCIHDGEIFADGASLK--GKNACEHCYCMRGDIVCAVQECEVPMMAANGKSCRAMPAA-EGECC 294
            ..|....:.:|:|..::  ....|:.|:|:||...||.::|...:     |:|  :|.. :|:||
  Fly   235 RGCTVGAQFYAEGQKMRSDADKPCDICFCIRGTRRCAPKKCSPAL-----KNC--IPVVPKGQCC 292

  Fly   295 PSNYVCEDDSSTTEIVEITTPESATSVPAKGIHAEIPKEDVDLQEHI------DDDDKNKETATI 353
            ||:|.|                        |...:..:.....|.::      .::.:.:.||.|
  Fly   293 PSSYDC------------------------GSQRDYRRSHNSRQFNLYNMLFGKEEPEQQGTALI 333

  Fly   354 PSAELGSGEIEEEEEEKDKATTVAPVQVTDEKDFSFEPESSTAGIPSDSRID-LPSSTE--ESKE 415
            |...:  .|....:....:||...|::|:.||                |.:| |....|  :...
  Fly   334 PQNSM--AERYPHDRHPTRATLGNPLEVSSEK----------------SIMDTLREGLEFIDGNN 380

  Fly   416 SSTEAAEEDIVKIVTTPEP---EGSGEEDVPKPSQI--------PEKEITEDELIKVSTSAPAK- 468
            :...|...|:|.|.||..|   .....|:|...:.:        |..|.|..|.|:...|..||
  Fly   381 NKMLANNLDLVGIRTTQAPPLMRTESSEEVSSTTALSFLDLLLGPNTETTSHEEIRQPESTTAKN 445

  Fly   469 --------ASPEEEVVTATTSAPTE--------EDVKPTT------AGTISEEEEEGK------- 504
                    ..|:||.:...|.|..|        ::..|:|      |....|:.:.|:
  Fly   446 TLSWMDILLGPDEEELGPKTEAYLETSTTLNQPDEFNPSTNSIKRIAEDFDEQLDNGEMAVGELP 510

  Fly   505 --------------PTPAEEG------------------SGEEEKDVKVTAAPEETEDEA-KPTS 536
                          ||||.|.                  ||..|:.:..||:...|.... |||:
  Fly   511 AEAQQIGIANAGIWPTPATEVMPPPKEEPSLFNVLIDGLSGILEEPLNQTASSTSTTTTTEKPTN 575

  Fly   537 APVASDEKEQEPKPSEGSGDEELDLK-------------------PTTAPTA----GATSASEES 578
            .|.....:   |.||.......::.|                   |.|..||    .||::|..:
  Fly   576 LPAPPMFR---PLPSGKPVHTRINSKLANLTVTPPMLVVTSKYGQPVTHRTANKRVNATTSSTIA 637

  Fly   579 EEQDE-GKSTEAPTSVDD-----------IEPAKPTESSEEASGEGEDVAKETTPAGEASIAGEE 631
            :..|: ..||...|.||.           ::| ||..:.:..:.......|.|||....|
  Fly   638 KSTDKPSTSTTQQTKVDSTIKTTATPSTTVKP-KPRTTRKTITTSKPTTPKPTTPKTTTS----- 696

  Fly   632 EIVKGTTPAGEPSSEGDEEIVKGTTPAEESSSESEDELTKVTTP---AGEPSVAGEEEIAKETTP 693
               |.|||             |.|||...:...|   .||.|||   :.:|::..:....:.|||
  Fly   697 ---KPTTP-------------KITTPKPTTPKPS---TTKTTTPKSSSAKPALPPKSTTQRPTTP 742

  Fly   694 AGEPSIAGEEEIVKVTTPAGESSIAGEEEIVKVTTPAGESSSEGE-------------EEIIKVT 745
            .  ||           |||..::......  ..|.|...::|:.:             :.::..|
  Fly   743 I--PS-----------TPAPTTTTTSTTS--TTTKPTLRTTSKSKFKPKPKPYVTSTPKPLVIET 792

  Fly   746 TPA----------GESS---------------SEGDEEIVKESTPAG---EPISEGEEDVIKATT 782
            .|:          ||.:               ::..:.:.||..|..   :.::..:.||:...|
  Fly   793 NPSILEAEPLDINGEPTLPPSLPNLKIIPFLPTDAVDTVPKEQYPTNFYQQKVASDKMDVVGYDT 857

  Fly   783 SAPKSDIEGVKEPETA-------TEVPAEEVE--------------------DFAKPT------- 813
            ......:....:|:.|       .||||.|..                    ||..|.
  Fly   858 MDDTVALYSQSQPDQAAYKYKFNVEVPAVESAPEPVVHVGGKYEGSAAYVNFDFESPVVPPPHNG 922

  Fly   814 -TPIAEAE-----EEPI-------------AGTPIPTDGI-----------SGEEE----IVKGT 844
             :|..|.|     :||:             :|...|.|..           ||.:|    .::.|
  Fly   923 FSPPTETEGGFMPKEPLVIDGEILQEHVTSSGIGGPVDNFHVTQHIIDITTSGAQENDTASIEIT 987

  Fly   845 TPQTL------EEQPEISE----ESTEVPVAED------DLSSSTSASAIASSTEGVQDAASETT 893
            ||...      |..|.:.|    ::.:.|:.|.      .:|:|| ||:|:|||.|.....|.:|
  Fly   988 TPDPFKDVIHTEPSPNLDELIVDKANKKPIEEHIETVTYSVSNST-ASSISSSTSGTTSTTSTST 1051

  Fly   894 SS-----AP-------------------ARAGDKDEAATTVPTAQDKDDEEVEQDATDLPVEDVV 934
            |:     ||                   ....::|.|:.|||.        .:|..|..|.  :.
  Fly  1052 STTTEKEAPLIDKYEINKLDKLLDELLGMELSEEDAASRTVPA--------FKQLPTATPT--IA 1106

  Fly   935 QSTTAKTTTTEQPKEESSTEAEDAEIEVTTSSPADKQEVPEAEPADKDHKDEEDVQTATDLPIKS 999
            :||||.|.|.......::|...........:|.:.:..|....||.|.:...::.||:.:.. |.
  Fly  1107 KSTTAATATAADASATAATATAAIASSTAATSTSGRPTVTTRAPAKKGNGKTKNKQTSGNRR-KV 1170

  Fly  1000 DIGPPVVDTEATTGQPETSDETAT------------------------DKPPSVYLPPGGEKDTE 1040
            ..|.....|.|||..|..:..||:                        ||.|.:        ||.
  Fly  1171 QSGTRRQSTPATTRSPPAATSTASTASTTAGLATTTGSTLHPFLNSPFDKLPFM--------DTS 1227

  Fly  1041 KEDETTATEPSVQEEPSKPVDISPVSQEVPSSTAKVDNRNDFETEKPTLPPSGEDQSSEPL---- 1101
            .|......:|..|::...|       |:......:..:.....|..||..||....|.|.:
  Fly  1228 YEVRPHRLQPQQQQQQQAP-------QQHEQPPQQQFHHYQHATRPPTAAPSAASSSPEDVHQDS 1285

  Fly  1102 --------PAMDLPAGIPGEGD---------CLVEGKTY-ANNTIVPATAPCDVSCKCISSLVAC 1148
                    ....|..|:||..|         |.:.|:.| ....||..::.| :.|||....|.|
  Fly  1286 GSGSVERTGGGGLVGGLPGGDDPLGQLKLAGCNIYGRMYRVGRIIVELSSQC-LECKCTEVGVKC 1349

  Fly  1149 QQMEC 1153
            ..::|
  Fly  1350 GPLDC 1354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tnc	NP_001247300.1	VWC	235..296	CDD:214564	17/63 (27%)
		PHA02664	<433..595	CDD:177447	53/259 (20%)
		Ehrlichia_rpt	529..1065	CDD:118064	149/747 (20%)
		DUF863	<1684..>1788	CDD:283539
		VWC	2762..>2805	CDD:302663
CG17211	NP_609552.1	VWC	237..294	CDD:214564	17/63 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45452691
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D380865at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR46698
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.040