DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tnc and Kcp

DIOPT Version :9

Sequence 1:	NP_001247300.1	Gene:	tnc / 42990	FlyBaseID:	FBgn0039257	Length:	2819	Species:	Drosophila melanogaster
Sequence 2:	XP_011239372.1	Gene:	Kcp / 333088	MGIID:	2141640	Length:	2120	Species:	Mus musculus

Alignment Length:	1770	Identity:	336/1770 - (18%)
Similarity:	538/1770 - (30%)	Gaps:	539/1770 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EGCYYNYAHYQEGDRIM-TNEPCLNCTCHNRMLMCYLRVCPFTK------------PIGHDCIVE 96
            :.|.|:...|..|.... .:.||..|.|.:..:.|.|..||||.            |...|||:|
Mouse   515 DSCTYHSLVYANGQNFTDVDSPCQTCYCEDGTVRCSLINCPFTTCAKPQNGPGQCCPKCPDCILE 579

  Fly    97 KR-----------EDQC-----------CPIITCPEVPVDVPYHSPEPGTELSIPEKFGCSIEEK 139
            .:           .|.|           |.:..||..|.   .| |.||| ....:..||:...|
Mouse   580 AQVFVDGERFPHPRDPCQECWCQEGQAHCQLRACPSAPC---VH-PLPGT-CCKNDCTGCAFGGK 639

  Fly   140 FYPEGAQVPSNPNKPCELCYCINNQTKCVMQECTLHVDGCLPIYNKGSCC--------------- 189
            .||.||..| :|..||.||.|::...:|:.:.|. .:....|:...|.||
Mouse   640 EYPNGADFP-HPTDPCRLCRCLSGNVQCLARRCP-PLSCPQPVLTPGDCCPQCPDAPADCPQSGN 702

  Fly   190 --PVRYS--------------CDHENELDFMDQSTTTTTTTVRPTTGFILASTMTP------PTT 232
              |||:.              |        :|.|.:....|..|      |....|      |:.
Mouse   703 MVPVRHQEHFFQPGDPCSRCLC--------LDGSVSCQRLTCPP------APCAHPRRDACCPSC 753

  Fly   233 TDCIHDGEIFADGASLKGKN-ACEHCYCMRGDIVCAVQECEVPMMAANGKSCRAMPAAEGECCPS 296
            ..|::.|:.||.|......| ||..|.|..|.:.|..:.| .|...       ..|..| :|||:
Mouse   754 DGCLYQGKEFASGERFPSPNVACHVCLCWEGSVKCEPRTC-APAQC-------PFPTRE-DCCPA 809

  Fly   297 ----NYVCEDDSSTTEIVE--------------ITTPESATSVPA-------------------- 323
                :|:.....|:.|..:              :|........||
Mouse   810 CDSCDYLGVSYLSSQEFPDPREACNLCTCLGGFVTCTRRPCEPPACSHPLIVPEHCCPTCQGCLY 874

  Fly   324 KGIHAEIPKEDVDLQEHIDDDDKNKETATIPSAELGSGEIEEEE------EEKDKATTVAPV--- 379
            .||.|.:.:   .|.:.:|      .|.::.:.|.||...:::.      ..........||
Mouse   875 HGITAALGE---TLPDPLD------PTCSLCTCEEGSMRCQKKPCPPAPCAHPSPGPCFCPVCRS 930

  Fly   380 ---QVTDEKD-FSFE-PESS------TAGIPSDSRIDLPS--STEESKESST---------EAAE 422
               |..:.:| ..|| ||.|      .||..|.:|:..||  ...:..|..|         ...|
Mouse   931 CLSQGREHQDGEEFEGPEGSCERCRCLAGQVSCTRLQCPSLPCLHQVTEPGTCCPRCTGCLARGE 995

  Fly   423 EDIVKIVTTPEPEGSG--EEDVPKPSQIPEKEITEDELIKVSTSAPAKASPEEEVVTATTSAPTE 485
            |         .||||.  ..|.|..|.:..|.|.....::   ...|...|:|        .|:
Mouse   996 E---------HPEGSSWVPADSPCSSCMCHKGIITCAQVQ---CVSACIWPQE--------GPS- 1039

  Fly   486 EDVKPTTAGTISEEEEEGKPTPAEEGSGEEEKDVKVTAAPEETEDEAKPTSAPVASDEKEQEPKP 550
             |..|..:|             .|.|..:.|..       |..:..|.|....:.   |||...|
Mouse  1040 -DCCPQCSG-------------CEHGGRKYEPG-------ESFQPGADPCEVCIC---KEQADMP 1080

  Fly   551 SEGSGDEELDLKPTTAPTAGATSASEESEEQDEGKSTEAPTSVDDIEPAKPTESSEEASGEGEDV 615
                          |||             :|.|.:...|                   |..|.:
Mouse  1081 --------------TAP-------------KDMGVADRYP-------------------GAREQL 1099

  Fly   616 AKETTPAGEASI-AGEEEIVKGTTPAGEPSSEGDEEIVKGTTPAEESSSESEDELTKVTT----- 674
            |..:  .|.:|: :.....|:| .||        ..:|.|:.||..::.::...|...:|
Mouse  1100 AFHS--LGLSSVHSCCSRSVRG-LPA--------FTVVGGSAPAWWAAHQASFFLLAPSTAVPPV 1153

  Fly   675 PAGEPSVAGEEEIAKETTPAGEPSIAGEEEIVKVTTPAGESSIAGEEEIVKVTTPAGESSSEGEE 739
            |....|...|:.:..|..|.........:::..:.|         .....:::.|..|
Mouse  1154 PVKALSNCTEDLVGSELVPPDPCYTCQCQDLTWLCT---------HRACPELSCPLWE------- 1202

  Fly   740 EIIKVTTPAGESSSEGDEEIVKESTPA----GEPISEGEEDVIKATTSAPKSDIEGVKEPET--- 797
               :.|||....      .:.|:.|.:    |..::.||:..:.|.||.  |.:.|....:|
Mouse  1203 ---RHTTPGSCC------PVCKDPTQSCMHQGRWVASGEQWAVDACTSC--SCVAGTVHCQTQRC 1256

  Fly   798 ------ATEVPAEE-----VEDFAKPTTPIAEAEEEPIAGTPIPTDGISGEEEIVKGTTPQTLEE 851
                  ..||||..     :....:|.:.:|..  :|...|      ..|.....:|:....|.:
Mouse  1257 RKLACSRDEVPALSPGSCCLRCLPRPASCMAFG--DPHYRT------FDGRLLHFQGSCSYVLAK 1313

  Fly   852 QPEISEESTEVPVAEDDLS----SSTSASAIASSTEGVQDAASETTSSAPARAGDKDEAATTVPT 912
              :...|...|.|..||..    :.|...|:...|..|:.....|..        .|:...|:|.
Mouse  1314 --DCHGEDFSVHVTNDDRGRRGVAWTQEVAVLLGTVAVRLLQGRTVM--------VDQHTVTLPF 1368

  Fly   913 AQD----------------KDDEEV---EQDATDLPVEDVVQSTTAKTTTTEQPKEESSTEAEDA 958
            .::                :...:|   .|...::.|....:..|...........:...:..|.
Mouse  1369 LREPLLYIELRGHTVILHAQPGLQVLWDGQSQVEVRVPSSYRGQTCGLCGNFNGFAQDDLQGPDG 1433

  Fly   959 EIEVTTSSPADKQEVPE----AEPADKDHKDEEDVQTATDLPIKSDIGPPVVDTEATTGQPETS- 1018
            .:..|.:|..:..:||:    ..|.....  |.|...|.....:.       :..|..|..:||
Mouse  1434 RLLPTEASFGNSWKVPKGLGPGRPCSAGR--EVDPCRAAGYRARR-------EANARCGILKTSP 1489

  Fly  1019 -DETATDKPPSVYLP----------PGGEKDTEKEDETTATEPSVQEEPSKPVDISPVSQEVPSS 1072
             .......||..:..          ||...||...|...|.....::....||...|.
Mouse  1490 FSHCHAVVPPEPFFAACVYDLCACGPGSSSDTCLCDALEAYASHCRQAGVTPVWRGPT------- 1547

  Fly  1073 TAKVDNRNDFETEKPTLPPSGEDQSSEPLPAM--DLPAGIPGEGDCLVEGKTYANNTIVPATAPC 1135
               :...:.:.::.|..|.:..|.....|||:  ..||     ..||..|..      :|.|
Mouse  1548 ---LCGNHSWVSKTPLQPQASLDPVPTSLPALCRSRPA-----SKCLTAGLE------LPMT--- 1595

  Fly  1136 DVSCKCISSLVACQQMECKLPENLEKCT-VAADLLDGCCPTY--ICDESTESAEKDEESTAKPDN 1197
                  :..:...|:.:.||..:||..| |...|.   .|.:  .|.:.:::.....:.:.....
Mouse  1596 ------LLEMEGSQRAQEKLLWDLELLTGVGLGLF---WPPWAGYCSQRSQTQYAQSQCSQSWGR 1651

  Fly  1198 KIDEDVSEISTEEIP---------------KDVIMPTGITEQPLSHVKPDEE------IQPVTSV 1241
            .:|||..::|::..|               |..:.....:...|...:.|.:      |.|..:|
Mouse  1652 SVDEDFEQLSSKLCPPPQAGEAHSESHQLLKGKLATDSSSASDLEEARSDGDPRLEGPIMPAKAV 1716

  Fly  1242 PAQFD-----------------ESTTAKVDKKPIDESAEDKKPIGESE-EDSKPIDESEEDKKPV 1288
            |....                 .||.:...|:|           |.|| :|...::|..:.:..:
Mouse  1717 PGSSTGEGQEAGGAGVPGAGCLHSTNSSSFKEP-----------GNSELKDPGKMEERSQAEPNI 1770

  Fly  1289 EESAED--KKPVEDSEEKEKPLPTVIPA---SEIEKESKP-----EDEKKTEADFAAPTEQPEAT 1343
            :.|...  :...|....:|.|.|:.:.:   |.::..||.     ..|:........|...||.|
Mouse  1771 QSSFGQTLRSTQEGKLGQEGPEPSDLASQGLSALQDLSKGLGSGLSQERAAPQTLLTPQGHPEET 1835

  Fly  1344 TPAQIADTAEKEVDDKLATTSAPVSGEDELKPADEKKRTETAQIPDAEIPASTDEPESST--ELP 1406
            ...|...:.:       ......:.|:|:..|..:.:|.:..|..:.:||...:..:|..  |:.
Mouse  1836 PQGQRGQSPQ-------GYKGESIQGQDKGVPQSQSERKQAQQGQEFKIPPLQEGSKSEVWEEVQ 1893

  Fly  1407 TVDLDKKPEEDSTKGTEAPESD--KVPEVPTSASTENEIEESDKFTTVAPPKISASDETEPTAEE 1469
            ......:.|||..:|   ..||  |.||.|.....|..|         |.|:..::..|:..|.:
Mouse  1894 RGATVWRQEEDKPQG---HPSDFCKSPEKPIPQHVEKGI---------AGPQGGSTQVTQAAATQ 1946

  Fly  1470 DLVPATFEPIESEFEVSTKKPAVQGPPLPTLAPAQPEKKPVDAETSTEADISTEPSAEVEKEASG 1534
            :   .|:.|        ...|.:|||....|.....|::|.......|..:..:|     |.:..
Mouse  1947 E---GTWAP--------PTPPQLQGPEGGILVSEAQERQPRLPSALREQRVPRDP-----KPSKD 1995

  Fly  1535 ETSESDNEIDAGASS 1549
            ...|..|..||.||:
Mouse  1996 AWPEPRNREDALASA 2010

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tnc	NP_001247300.1	VWC	235..296	CDD:214564	18/61 (30%)
		PHA02664	<433..595	CDD:177447	32/163 (20%)
		Ehrlichia_rpt	529..1065	CDD:118064	100/598 (17%)
		DUF863	<1684..>1788	CDD:283539
		VWC	2762..>2805	CDD:302663
Kcp	XP_011239372.1	VWC	166..220	CDD:278520
		VWC	224..280	CDD:327433
		VWC	285..341	CDD:327433
		VWC	344..399	CDD:327433
		VWC	458..514	CDD:278520
		VWC	517..573	CDD:327433	15/55 (27%)
		VWC	634..690	CDD:327433	19/57 (33%)
		VWC	<717..753	CDD:327433	8/49 (16%)
		VWC	931..987	CDD:327433	15/55 (27%)
		VWC	<1173..1214	CDD:214564	6/65 (9%)
		VWC	1221..1278	CDD:214564	13/58 (22%)
		VWD	1285..1432	CDD:365869	23/164 (14%)
		C8	1482..1549	CDD:370094	14/76 (18%)
		Glutenin_hmw	<1757..>1975	CDD:367362	48/247 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR46698
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100