DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tnc and DMP1

DIOPT Version :9

Sequence 1:	NP_001247300.1	Gene:	tnc / 42990	FlyBaseID:	FBgn0039257	Length:	2819	Species:	Drosophila melanogaster
Sequence 2:	XP_011530007.1	Gene:	DMP1 / 1758	HGNCID:	2932	Length:	542	Species:	Homo sapiens

Alignment Length:	543	Identity:	117/543 - (21%)
Similarity:	212/543 - (39%)	Gaps:	112/543 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 SEEEEEGK------PTPAEEGSGEEEKDVKVTAAPEETEDEAKPTSAP--VASDEKEQ------- 546
            ||:.||.|      |||..| |.|..:..||::..:..||.:..|.:.  :.||:.:.
Human    56 SEDSEEWKGHLAQAPTPPLE-SSESSEGSKVSSEEQANEDPSDSTQSEEGLGSDDHQYIYRLAGG 119

  Fly   547 -EPKPSEGSGDEELDLKPTTAPTAGATSASEESEEQDEGKSTEAPTSVDDIEPAKPTESSEEASG 610
             .....:|..|::.|...:...|.|...:....:::.||.::...:..|..:   ..::|||::.
Human   120 FSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDD---TIQASEESAP 181

  Fly   611 EGEDVAKETTPAGEASIAGEEEIVKGTTPAGEPS--SEGDEEIVKGTTPAEES---SSESEDELT 670
            :|:|.|::||  .|:.....|:.|......|:.:  ||.:|..|.|.:..|.|   .||.:||..
Human   182 QGQDSAQDTT--SESRELDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSELDDEGM 244

  Fly   671 KVTTPAGEPSVAGEEEIAKETTPAGEPSIAGEEEIVKVTTPAGESSIAGEEEIVKVTTPAGESSS 735
            :...|   .|:..|...::..:...:...:||......|..:|.|.:. |....|:...:..|..
Human   245 QSDDP---ESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLL-EHPSRKIFRKSRISEE 305

  Fly   736 EGEEEI------IKVTTPAGESSSEGDEEIVKESTPAGEPISEGEEDVIKATTSAPKSDIEG--- 791
            :...|:      .:|.:.:.|:|:..|..:   |.|..:...:.:||..:..:.....:::|
Human   306 DDRSELDDNNTMEEVKSDSTENSNSRDTGL---SQPRRDSKGDSQEDSKENLSQEESQNVDGPSS 367

  Fly   792 -----------VKEPETATEVPAEEVEDFAKPTTPIAEAEEEPIAGTPIPTDGISGEEE---IVK 842
                       ....|:..||.:|...|...|||...|.:|          |..|.||:   .:.
Human   368 ESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQE----------DSDSSEEDSSHTLS 422

  Fly   843 GTTPQTLEEQPE--------ISEESTEVPVAEDDLSSSTSASAIASSTEGVQDAASETTSSAPAR 899
            .:..::.|||.:        .||||.|.|  ||:.|         ||.||:|..:|...|.:...
Human   423 HSKSESREEQADSESSESLNFSEESPESP--EDENS---------SSQEGLQSHSSSAESQSEES 476

  Fly   900 AGDKDEAATTVPTAQDKDDEEVEQDATDLPVEDVVQSTTAKTTTTEQPKEESSTEAEDAEIEVTT 964
            ..::|          |.|.::..:...|       .::|...:::|:..:..:.|.|..::.|..
Human   477 HSEED----------DSDSQDSSRSKED-------SNSTESKSSSEEDGQLKNIEIESRKLTVDA 524

  Fly   965 --SSPADKQEVPEAEPADKDHKD 985
              :.|...|:       |.|.:|
Human   525 YHNKPIGDQD-------DNDCQD 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tnc	NP_001247300.1	VWC	235..296	CDD:214564
		PHA02664	<433..595	CDD:177447	25/113 (22%)
		Ehrlichia_rpt	529..1065	CDD:118064	104/505 (21%)
		DUF863	<1684..>1788	CDD:283539
		VWC	2762..>2805	CDD:302663
DMP1	XP_011530007.1	DMP1	30..542	CDD:284637	117/543 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1181
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900